Basic Information

Gene Symbol
Manf
Assembly
GCA_963575645.1
Location
OY754473.1:17140857-17147897[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.037 0.76 10.9 3.2 1 23 214 237 214 237 0.96
2 11 1.3e-05 0.00028 21.7 0.5 1 23 391 414 391 414 0.97
3 11 0.00027 0.0055 17.6 1.6 1 23 461 484 461 484 0.97
4 11 3.9e-05 0.00081 20.2 0.2 1 23 495 517 495 517 0.96
5 11 0.00035 0.0073 17.2 0.7 1 23 523 545 523 545 0.97
6 11 0.01 0.21 12.6 0.2 1 23 551 573 551 573 0.98
7 11 1.1e-05 0.00022 22.0 0.1 1 23 579 601 579 601 0.99
8 11 0.00027 0.0055 17.6 3.7 1 23 607 629 607 629 0.97
9 11 0.00083 0.017 16.1 4.0 3 23 637 657 635 657 0.98
10 11 9.4e-06 0.00019 22.2 0.8 1 23 663 685 663 685 0.97
11 11 7.8e-05 0.0016 19.3 1.6 2 23 692 714 691 714 0.94

Sequence Information

Coding Sequence
atggaaataATTGACTTTGATAATATATGTCGTATTTGTTGGAACGACTCGTTTTTAAGGACGGTATTTAATGAAGATATACCGTCTTTATGCGAGATGCTTATGGCGTGTGCTCCTCTCGAgGTTTGCCAAGAAAATGGCCTTCCAACAAAAATCTGCGAAAACTGTAGTTCAGATTTAGAAAAAGCATACGCGTTTCGTGAAAAGTGTATTCAGTCTGAAATGAAATTCAGAAAATATTTCGACGACAACGCAGTAATTATCACAGATAAAGCAGACCTCACATATGAGCCAGAAACAGTTATTGTCATGGAAGAGTTCGGAGAAGATGCATATTTGGCAACAAATGAGAATGGTGAAACTACTTTAATTCAGGCTTCCAGTCTGGATCCGAGTATAAAAGCAAGTCTCGAAGCTGCTACTTTGGAAGGAAAAGCAACAACGACAGTCATAACAACAGACGAGAACGGAACTGTTATAGAAGACGATGCTACTTTAAAGgatGTAACCATTATCACAGAAGATGAAACTGAAGAAATCGATATATCAAACATGTTAGAATTTCAAGACAGCACCGATGAAATAATCGAAACAACAGTTACAACGGAATCGGAAGAACAACAACagtcggtgaaaaaattttcgtGTCATTTATGCGAAAGAGAGTATTTGCATCCGAGAAATTTGAAAAGACACGTACGGGAAGACCATAGCGGCATTTTGGGTGAAATAGAAAATTATACGGATGACGCAGATGATTCTGATGACGATTATTCGGATAATTTGAGTGAACACGCGTTCCAATTTTCGTCGGTCGTGATAAACGACGATGAAAATAAAGCGGCAGAGGTCAAAGTTGAACCGGAATTCGATAGTCCACCCGGTGGTAAAATATTACAGACGTTGTTATTGACAAAATCGGGGAAACAGAAAATCAAACACGCTCCCGACAGTAGACGAGGGCAGAAAGTGAAAGTTGTAAAAAATTTAGTTGAATTGAAAGATCAAATGGAAAAAAAGAACAGTAGctcaaaaaagacaaaaaaggaCACTGAAGATCAGACTGTGTTTATTGTCGAAGAAGGGATTTTTAAGAATATTTTCCAGTCCCAGGAAGACAGTCAAGAAGAATCGGATTTAAGAGAAGAGGTCGATGATCAGAAACCTCAGTTTGTGTGCGATTTGTGtggtaaattatttacaatcagaAGCAATTTGAAAAGACATTTAAATATGGTACATCGTGTGGCCGAAAAGGTAAAGGACAACGGTGAATTTAACTATTCTTCGACCGTTACCGATGAAGTcatagaagaaataaaaaatgaacataaAGGATATGAAGAAGATGTTAATGAAGATggcacaaaaacaaaaaaatatcaatgtgaTATGTGTGAAAGGTCGtattacgcaaaaaataatctgaaaagacatataaaagaaaaacatcTACCGAAAGAGCCAACGCCTGACCGGGAATTCATGTGCGAACTGTGTGGAAGAGCGTTCGCCCGTAAAGGTTTGTTGGAACGACACAAAGATAGTCATTTAGAACGGCAGGGTCACCAATGCGAACAGTGCGGCGAAGTATTCCCGAAAAAAGGAAAATTATCGCAACACGTCATCAAACACCAAAGAGAGAAAAAATACCAATGCGACGTCTGTGGAAAATGGTTTTTGAGACCGGCTACCCTCAAAATACACAAGCGATTACACGATCCGGTGCTACCGTATCCGTGTACAGTATGTTCGCGAGCGTTCAGTATGAAGCCGGCTCTTGAAGCGCACATGAGAACTCACAGTTCCGAGAGGCCGTTCATTTGTTCGTACTGCAGGAGAGCCTTCCGACATCCCGGACACCTCGATACACATATGAAATTGCATACAGGTGAACGGCCGTTCGGTTGTAACATGTGCACGAAgcGTTTCACAACAACAACGCATTTGAAATATCATATAAAAGTGCATTTAGGCCAACGGGACTATAAGTGCGAGTACTGTGATAGAGCGTTTATTAATCGATCGGAACTTAAATATCATTTAGTGTCGCATACGCAGATCAAAACTTGTCCGTGCAGTATTTGTGGAAAAATGTTCGGACGTACTTATCAAGTGACGAAACATATGAGACAAGTGCATAAGATACGAAAAAATTTCTTTGCGCCAGCACCaaataaattcacagATATGGAATCAATAACGAATCTCTTTTATATGCTAACAGTACTATTAGCTGTGGTATCTTCAGTAGTATCATTAAAAGAAGGCGAATGTGAAGtgtgcATTAAAACAATTGAGAAATTTAGTAATTTACTATCAGCTGAAACCAAAAAGACTCCAAAGTTAATAGAGGAAGAGTTTAAAAAGTTCTGTAAAGggacaaaaaataaagaaaatcgaTTTTGTTATTACTTGGGAGGCTTAGAAGAATCAGCAACTGGTATTCTTGGTGAAGTTTCAAAACCGTTGTCGTGGAGTATGCCGTCTGATAAAATTTGCGAAAAACTTCGTAAAAAAGACGCTCAGATTTGTGATCTCCGATTCGATAAACAGATTGATTTAAAAAcagtcgatttaaaaaaattgaaagtgcGCGActtgaagaaaattttaaacgatTGGGACGAAACTTGTGAAGGATGTATTGAGAAGACCGATTTTATCAAACGAATCGAGGAATTGAAACCACAATATGTCCATTCAGAACTATGA
Protein Sequence
MEIIDFDNICRICWNDSFLRTVFNEDIPSLCEMLMACAPLEVCQENGLPTKICENCSSDLEKAYAFREKCIQSEMKFRKYFDDNAVIITDKADLTYEPETVIVMEEFGEDAYLATNENGETTLIQASSLDPSIKASLEAATLEGKATTTVITTDENGTVIEDDATLKDVTIITEDETEEIDISNMLEFQDSTDEIIETTVTTESEEQQQSVKKFSCHLCEREYLHPRNLKRHVREDHSGILGEIENYTDDADDSDDDYSDNLSEHAFQFSSVVINDDENKAAEVKVEPEFDSPPGGKILQTLLLTKSGKQKIKHAPDSRRGQKVKVVKNLVELKDQMEKKNSSSKKTKKDTEDQTVFIVEEGIFKNIFQSQEDSQEESDLREEVDDQKPQFVCDLCGKLFTIRSNLKRHLNMVHRVAEKVKDNGEFNYSSTVTDEVIEEIKNEHKGYEEDVNEDGTKTKKYQCDMCERSYYAKNNLKRHIKEKHLPKEPTPDREFMCELCGRAFARKGLLERHKDSHLERQGHQCEQCGEVFPKKGKLSQHVIKHQREKKYQCDVCGKWFLRPATLKIHKRLHDPVLPYPCTVCSRAFSMKPALEAHMRTHSSERPFICSYCRRAFRHPGHLDTHMKLHTGERPFGCNMCTKRFTTTTHLKYHIKVHLGQRDYKCEYCDRAFINRSELKYHLVSHTQIKTCPCSICGKMFGRTYQVTKHMRQVHKIRKNFFAPAPNKFTDMESITNLFYMLTVLLAVVSSVVSLKEGECEVCIKTIEKFSNLLSAETKKTPKLIEEEFKKFCKGTKNKENRFCYYLGGLEESATGILGEVSKPLSWSMPSDKICEKLRKKDAQICDLRFDKQIDLKTVDLKKLKVRDLKKILNDWDETCEGCIEKTDFIKRIEELKPQYVHSEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01511225;
90% Identity
iTF_01511225;
80% Identity
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