Basic Information

Gene Symbol
-
Assembly
GCA_963575645.1
Location
OY754465.1:60717480-60735240[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 6.7e-05 0.0014 19.5 3.4 1 23 1002 1024 1002 1024 0.98
2 16 1.1e-05 0.00022 22.0 0.4 1 23 1030 1052 1030 1052 0.99
3 16 2.5e-06 5.2e-05 24.0 5.3 1 23 1058 1080 1058 1080 0.99
4 16 2.5e-06 5.2e-05 24.0 5.3 1 23 1086 1108 1086 1108 0.99
5 16 0.00012 0.0024 18.8 4.3 1 23 1114 1136 1114 1136 0.99
6 16 3.8e-06 7.8e-05 23.4 2.9 1 23 1142 1164 1142 1164 0.99
7 16 0.0059 0.12 13.4 3.6 1 23 1170 1192 1170 1192 0.98
8 16 4.8e-05 0.00098 20.0 3.9 1 23 1198 1220 1198 1220 0.99
9 16 6.7e-06 0.00014 22.7 2.8 1 23 1226 1248 1226 1248 0.99
10 16 4.7e-05 0.00096 20.0 1.9 1 23 1254 1276 1254 1276 0.99
11 16 0.0042 0.086 13.9 9.2 1 23 1282 1304 1282 1304 0.98
12 16 0.0013 0.026 15.5 2.1 1 23 1310 1332 1310 1332 0.99
13 16 2.7e-05 0.00055 20.8 2.2 1 23 1338 1360 1338 1360 0.99
14 16 0.00029 0.0059 17.5 4.2 1 23 1366 1388 1366 1388 0.99
15 16 5.3e-05 0.0011 19.8 2.1 1 23 1394 1416 1394 1416 0.99
16 16 3.7e-05 0.00076 20.3 5.9 1 23 1422 1444 1422 1444 0.99

Sequence Information

Coding Sequence
ATGTGTCGGTTGTGCTTATCAAAAGGTGTTAAGCTAttagacatattttatttttcgtccgAAATGAAAAATCAACTATCGAACATCATCATGTGGTGTGCTCCCGTTCAGATAACAAGATATGATAATATGCCGAAATTCATCTGTCAGTTATGTTACACTCAAATCAAGAAAATTCACGAGTTTCAGGTGCAAATAGTACAATCTGATAAGACATTGCGACGTTATCTACAACAATTTTATGTTTATGACCAGAaaatcaaacctgaatgttccaGTCAAAATTCTTCTGAGGaacatttaattcataaaaccAACCATTGTGATGTGCCTGTTCAATGTGAATCTATGGTATTTCATGATATATTTGGCATGAATCTTGACCCGAAAGAAACGAcgcctataaattataattcagtAAACAAAATTAACGAAGAAATaccttttaaatttgaaattaaggACGAACGAACGAATGATAATTCATTGAACTTAACAGAATGTGCTGACGATACAGTAAAAACTTTATGTACGAGTGGCGGTAGCGAAATCGGCACCGAAGACTCAGATATTTATAGTGACATATCGGTAAACAAAATTAACGAAGAAAtgcctttaaaattcgaaatcaaAAACGAACCAACGAatgataattcattaaatttaacaGAATGTGCTGACGATACAGTAAAAACTTTATCTACGATTGGAGACAGCGAAATCGGCACCGAAGACAcaaacatttatagtgaccCTATATCAGTATACAATATTAACGAAGAAATGTCCTTAGAATTCGAAATCAAGAACGAACCAATAAAcgataattcattaaatttaataGAATGTGCTGACAATACACTAAAAACTTTATCTAAAGGTGGCGGTAGCGAGATCGACCTCGAAGACACAAATATATATAGTGACCTTATATcagtaaacaaaattaatgaagaaatgcttttaaaattcgaaatcaaagacgaaccaaCGAGTGAAAATTCTCTAAATCAAACAGAATGTGCTGACGATACTATGGAAACTGTATCTACGAGAGACGGAATAAATGTGGAAGAATTTGAGAAAATGAAAGCtgaaaagcaaattttaaaatgggtgtgcgaaaactgcaaaataaaaGCTAACCTAAAACAAGTTAACTGCAACGTGATTGATAACACGGGCAATAAAACGGAAGCACTGGAAATGAAAATAGACATAATGATGGAACAACAAAATGCATTAATAGAAACAATTAaggaattgaataaaaaaattgatacactaatgacagaaaataaaaaaaacaacataatcgTAACGGAATTAAAAAATGAGGTTAGTAATCAAAAAAAGGAATCTCTTGGAGAAAGTACATTAGATAGCTATGTTGATGTTCCCAAACATAACCAAGTGAAAACAAACCCGTCTATAGAAACCAGGACAAAAGCTACTAGAAGTAACAATGagacgaaaaaagaaaatatagagCACAAGCCAGCTGAAGTAAATTCTGTACTATCGGCCAGAAGTAATGGAAAAGAGAAAACGGAAAAGGTAGTAAATGTTACCCAGAACGAAACTCATAGTAATGCGAATGAGCCTAATAAGGCAGAAAAAGATGACAATGaatggaaaaaaattgagagAAAAAGACGAAGAGCTGGAGGTATAATTGGAAAAGCGGATAACACTGAACTACAGGCAACCGATAAGAAAATATGGCTGTTCTTGGGAAAAGTACGGCAGGGAACAACTAAAGAACAAGTATTAAACTATCTTAAGAACAAGTGTCCAGATCATAACAAATTTGGTGTAGAGGAAATACAAACTAATGGCATAAATTCCTGTTTCAAAGTTTCGGCCGGTTATGAACTGAAAGATCAGATTGAACATTGGCTATATCGAAATGAAATTGAAAGTTtgtgtataaataattataaaaatGAACAAAACGGTTTTGTAAAAGGAGGTTCCACTATTAAAGCAATATTTGATGTTACCGACAGCTTATACGATGCGTGGGACAAAAAACAGCCAACGGTTGCTCTCCTGCTTGATTTGTCTAAGGCTTTTGATTGTATAAGAAGATATGATAATATGCCCAAATTCATCTGTCAGATATGTTACACACAAATCAAGAAAATTCACGAGTTTCAGGTGCAAATAGTACAATCTGATAAGACATTGCGACGTTATCTACAACAACTGCATGTTTATGATCAGAaaatcaaacctgaatgttccaGTCAAAATTCTTCTGAGAaacatttaattcataaaaccAACCATTGTGATGTGACTGTTAAATGTGAATCTATGGTATTTCATGATATATTTGGCTTGAATCTTGACTCGGAAGAATCGACgtctataaattttaattcagtaAACAAAATTAACGAAGAAATaccttttaaatttgaaattaaggACGAACGAACGAATGATAATTCATTAAACTTAACAGAATGTGCTGACGACACAGTAAAAACTTTATCTACGAGTGGCGGTAGCGAAATCGGCACCGAAGACACGAATATTTATAGTGACACATCGGTAAACAAAATTAACGAAGAAAtgcctttaaaattcgaaatcaaGAACAAGCCAACGAAcgataattcattaaatttaataGAATGTGCTGACAACACAGCAAAAACTTTATCTACGAGTGGCGGTAGCGAAATCGACCTCGAAGACACAAATATTAATAGTGACCTTATATCAGTAAACAAAATTAACGAAgaaatgcttttaaaattcgatatCAAAGACGAAACAACGAGTGAAAATTCTCTAAATCAAACAGAATGTGCTGACGATACTATGGAAACTGTATCTACGAGAGACGGTAGCGAAATCGGcaacaaaaacacaaatatcGAAAGAGGCCTTATATTGGACAACGATGTAGCAGAATGTCGGGACAAAACGgaagatgaaaaaaataacattttgataaattatgAGAAACATAAAAAAGTAACTGAAAAGAAGTATCACTGTGAAATTTGTACAAAGAGATTTTCTAAatcttttaatttgaaaatacacGTTCGCATACATAAGAGTGGGAAACAatatcagtgtggcgtttgtaaaaAGAGTTTCAGCCAACCTGGCACTTTATCTATTCACAaacgcgtacatactggtgagaagcaattccggtgtgacgtttgcaacaagtGTTTCAGACAACGTagcaatttaaatattcacaaacgcacacatactggtgagaagccattccggtgtgacgtttgcaacaagtGTTTCAGACAACGTagcaatttaaatattcacaaacgcacacatactggtgagaagccattcCGATGTGACGTTTGCAGCATGTTCTTCGCCACGTCAAGTCATTTAAAGCAGcataaacgcacacatactggtgagaagccataccagtgtgacgtttgtaataagttctTCTCTACGTCAAGTTATTTAAATTTGCATAAACGcacgcatactggtgagaagccataccagtgtgacgtttgtaatacgTTCTTCTCCACGTCAAGTCAATTCAATTTTCATAAACGcatgcatactggtgagaagccataccagtgtgacgtttgcagcaTGTTCTTCGCCACGTCAAGTCATTTAAAGCAGcataaacgcacacatactggtgagaagccataccagtgtgacgtttgtaataagttctTCTCCacgttaaaaaacttaaagcaGCATAAACGCATACATACTGGTGTGaagccgtaccagtgtgacgtttgcagaATGTTCTTCTCCACGTCAAGTGGTTTAAACCAGcataaacgcacacatactggtgagaagccacaccagtgtgacgtttgtaatacgTGCTTTTCCAAGTCAAATCATCTAAAGGTTCATAAACGCAAGCATACCGGTGAgaagccgtatcagtgtgacgtttgtaatatgtTCTACTTAACGTCAAGTGATTTAAAGCGGcataaacgcacacatactggtgagaagccataccagtgtgacgtttgtaataaattctTCGCCATGTCAAACGATTTAAAGAAGcataaacgcacacatactggtgagaaaccataccggTGTGACGTTTGCTACAAGTGTTTCAATCAATCAGGCTATTTAAGtattcacaaacgcacacatactggtgagaagccttaccagtgtgacgtttgtaatatgtTCTCCTCAACGTCAAGTGATTTAAAGAGGcataaacgcacacatactggtgagaaaccataccggTGTGACGTTTGTCACAAGTGTTTCAGCCGATCAGGCTCTTTAAGtattcacaaacgcacacatactggttaG
Protein Sequence
MCRLCLSKGVKLLDIFYFSSEMKNQLSNIIMWCAPVQITRYDNMPKFICQLCYTQIKKIHEFQVQIVQSDKTLRRYLQQFYVYDQKIKPECSSQNSSEEHLIHKTNHCDVPVQCESMVFHDIFGMNLDPKETTPINYNSVNKINEEIPFKFEIKDERTNDNSLNLTECADDTVKTLCTSGGSEIGTEDSDIYSDISVNKINEEMPLKFEIKNEPTNDNSLNLTECADDTVKTLSTIGDSEIGTEDTNIYSDPISVYNINEEMSLEFEIKNEPINDNSLNLIECADNTLKTLSKGGGSEIDLEDTNIYSDLISVNKINEEMLLKFEIKDEPTSENSLNQTECADDTMETVSTRDGINVEEFEKMKAEKQILKWVCENCKIKANLKQVNCNVIDNTGNKTEALEMKIDIMMEQQNALIETIKELNKKIDTLMTENKKNNIIVTELKNEVSNQKKESLGESTLDSYVDVPKHNQVKTNPSIETRTKATRSNNETKKENIEHKPAEVNSVLSARSNGKEKTEKVVNVTQNETHSNANEPNKAEKDDNEWKKIERKRRRAGGIIGKADNTELQATDKKIWLFLGKVRQGTTKEQVLNYLKNKCPDHNKFGVEEIQTNGINSCFKVSAGYELKDQIEHWLYRNEIESLCINNYKNEQNGFVKGGSTIKAIFDVTDSLYDAWDKKQPTVALLLDLSKAFDCIRRYDNMPKFICQICYTQIKKIHEFQVQIVQSDKTLRRYLQQLHVYDQKIKPECSSQNSSEKHLIHKTNHCDVTVKCESMVFHDIFGLNLDSEESTSINFNSVNKINEEIPFKFEIKDERTNDNSLNLTECADDTVKTLSTSGGSEIGTEDTNIYSDTSVNKINEEMPLKFEIKNKPTNDNSLNLIECADNTAKTLSTSGGSEIDLEDTNINSDLISVNKINEEMLLKFDIKDETTSENSLNQTECADDTMETVSTRDGSEIGNKNTNIERGLILDNDVAECRDKTEDEKNNILINYEKHKKVTEKKYHCEICTKRFSKSFNLKIHVRIHKSGKQYQCGVCKKSFSQPGTLSIHKRVHTGEKQFRCDVCNKCFRQRSNLNIHKRTHTGEKPFRCDVCNKCFRQRSNLNIHKRTHTGEKPFRCDVCSMFFATSSHLKQHKRTHTGEKPYQCDVCNKFFSTSSYLNLHKRTHTGEKPYQCDVCNTFFSTSSQFNFHKRMHTGEKPYQCDVCSMFFATSSHLKQHKRTHTGEKPYQCDVCNKFFSTLKNLKQHKRIHTGVKPYQCDVCRMFFSTSSGLNQHKRTHTGEKPHQCDVCNTCFSKSNHLKVHKRKHTGEKPYQCDVCNMFYLTSSDLKRHKRTHTGEKPYQCDVCNKFFAMSNDLKKHKRTHTGEKPYRCDVCYKCFNQSGYLSIHKRTHTGEKPYQCDVCNMFSSTSSDLKRHKRTHTGEKPYRCDVCHKCFSRSGSLSIHKRTHTG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-