Basic Information

Gene Symbol
-
Assembly
GCA_963575645.1
Location
OY754475.1:18043062-18048218[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 25 0.00028 0.0058 17.5 7.0 1 23 179 201 179 201 0.98
2 25 9.4e-06 0.00019 22.2 1.4 1 23 207 229 207 229 0.98
3 25 4.4e-06 9e-05 23.2 2.7 1 23 235 257 235 257 0.99
4 25 1.6e-06 3.4e-05 24.6 1.1 1 23 263 285 263 285 0.99
5 25 6.7e-06 0.00014 22.7 3.8 1 23 291 313 291 313 0.98
6 25 1.1e-07 2.3e-06 28.3 0.8 1 23 319 341 319 341 0.99
7 25 0.00058 0.012 16.6 1.8 1 23 347 369 347 369 0.98
8 25 6.2e-06 0.00013 22.8 3.1 1 23 375 397 375 397 0.98
9 25 7.6e-06 0.00016 22.5 4.0 1 23 403 425 403 425 0.98
10 25 0.0022 0.045 14.7 3.4 1 23 431 453 431 453 0.97
11 25 3.4e-06 7e-05 23.6 3.2 1 23 459 481 459 481 0.99
12 25 1.9e-05 0.00039 21.2 2.6 1 23 487 509 487 509 0.99
13 25 8.8e-07 1.8e-05 25.4 2.1 1 23 669 691 669 691 0.99
14 25 0.00077 0.016 16.2 1.1 1 23 697 719 697 719 0.99
15 25 8.9e-06 0.00018 22.3 2.1 2 23 726 747 725 747 0.97
16 25 7.3e-08 1.5e-06 28.8 1.1 1 23 753 775 753 775 0.99
17 25 2.2e-06 4.6e-05 24.1 3.8 1 23 781 803 781 803 0.99
18 25 9.4e-05 0.0019 19.0 4.7 1 23 809 831 809 831 0.98
19 25 0.00062 0.013 16.5 5.1 1 23 837 859 837 859 0.99
20 25 7.9e-07 1.6e-05 25.6 1.7 2 23 866 887 865 887 0.97
21 25 2.1e-05 0.00043 21.1 4.3 1 23 893 915 893 915 0.99
22 25 2.4e-05 0.0005 20.9 3.1 1 23 921 943 921 943 0.99
23 25 3.5e-05 0.00072 20.4 5.2 1 23 949 971 949 971 0.97
24 25 3e-07 6.2e-06 26.9 2.1 1 23 977 999 977 999 0.99
25 25 4.7e-06 9.7e-05 23.1 3.3 1 23 1005 1027 1005 1027 0.98

Sequence Information

Coding Sequence
ATGGACGACAAGCTGGAAGAAAATTTGTCTGTGCATTTGAATGCTGGAAACAAAATGAATaatgtgatatttttaaaatccgaaatcaaagacgaaccgaTCGATGATAATGCATTATTTCCAACTGACTATGCTAAGAAAAACAGTTGCGAAGACACAAAAATCGATGTGAGCGACACGAAAGTAGGTGTAGAAACGGATTTCACCTGGAAAGAGACCGAATCTGCCACTTTTAATTCAACAAACGAAATCGACAATGGAATGTctttaaaatctgaaataaaggaAGAACCGGTCGATGATAATTCCATATTTTTAACTGAATATCTTGAATGCACAATAAACGATCCTTCTGATGGGGAACAAACTAAAATCACTTCGAAAGAAACAATTTCAGATTTTGATCACACATCGAGAAACTTCTCAAATCTTAGCTCTGATGGGCTGACAGAATATTTTGATGAATATAAAGAGCAGACCAAAAGTGGTATCTCAGTAAATTATGAGACGCATCAAAAACCAACTAAACAAAAGTATCATTGTGAATTTTGTAACAAGTCGTTTTCAAAGTCATGTAATTTGATTGTCCATAgacgtacacatactggtgagaaaccgcaccaatgtgacatttgtgaaAAGTCTTTCTCCGAGTTAGGCAATTTAAATGttcacaaacgtacacatactggtgagaaactatttcagtgtgacgtttgccaAAAGACTTTCAGTCGTACGAGTAACTTCGTAAGACATAAACGTGTACATACTGGCGATACACCATATCAGTGTGAGTTTTGTGAAAGATCGTTTTCCGACTCAGGAAATTTAAATGttcacaaacgtacacatactggcgagaaaccgCATCAATGTGAAGTTTGTCAAAAGACTTTCAGTCAAGCAAGCAATTTCTTAAGACACAAACGTATGCATACTGGTGTTACGCCGTATCAGTGTAACATTTGTGAAAAGTCTTTCTCGGACTCGGGCAATTTGAATGTTCACAAACGGACACATACCGGGGAAAAACcgcatcagtgtgacgtttgccaaaaatgtttcaatcaaGCTGGCGACGTCATCattcacaaacgtatacatactggtgagaaaccatatgaGTGTGACGATTGTAAGAAATGTTTTGCTCGATCGGTGGATTTGAAGAGACACAGTCGTTCACACAGAGGGGAAAAGCCGTATAAATGCGACATTTGTGAAAAGTGCTTTTCTAGATCATCCTATTTAAAGGTTCACAGTCGcttgcatactggtgagaaaccgtacgaATGTGACGTGTGTAAAAAATGCTTTCCTCAAACATCAAGTTTCGACAGACACAAAACcgtgcatactggtgagaaaccatatcagtgtgacgtttgtaaaaagtgctttCCTCAGTCGTCAAACCTCGACAGACATAAACGTGtacatactggcgagaaaccatatcagtgcgaCGTTTGTAAAATGTGCTTTCCTCAGTCGTCAAACCTCGACAGACACAAacgcatacatactgCTAACTGTGCTGATTATATAGTACGTGATGCTGGGGAAATGAGCTATGAAGACACTAAAATCGACGTGGGTGACACGAAAGTCAGCTTAAATGTAGATTTCAAGTGGCACGAAACAACTTCCACTTTTAGTTCAACAAACGAACGAATTTCtataaaatccgaaatcaagaTTGAACCGACGGTTGATAATTCATTCGTATTTATACCAAAATATGTTGATAACGAAAACACTACGTCTAACAGCAAAGTCAGTGAAACCAGTTTCGAAGACGCAAAAGCAGATAAAAAATCCGGAAACTTCTCCATTCTTCGCTCTGTTGAAGtaacaaataattttgataaatgtaAAGAAGAATATAAAAGTATTATAGTAAATTGTGAGAAACATGAAAAAAAGAATCAGGAATACGTTTGTGAAAAGTCTTCAGCCAATTTAATTGTTCGCAAACGTATACacaccggtgagaaaccgtatcagtgtgacgtttgtaaaaagcgTTTCACCCAAGCAGGCAGCTTAACAAGACATAAACGTACGCATACTGATGATacgccgtatcagtgtgacgtatgCGAGAATTTTTTTTCCGGCACGAGCGATTTAAATACCCACAAACGTACGCATACTGGGGAGAAACCGcttcagtgtgacgtttgtaataaacgtTTCACCCAAACGGGTAGCTTAACGAGACATAAACGTACGCATACCGGTGATACttcgtatcagtgtgacgtatgTGGAAAATTTTTCACAAACTCAAGCGATTTAAACGctcacaaacgtacacataccggtgagaaaccatttcagtgtgacgtttgtaacaagtgtTTCAGTCAATCAAGCAGTTTATTAGTCCACAAACGTACGCATACGGGTGATACACCGTATCATTGCGACGTCTGTGGAAAGTCTTTCTTTAACTCGTTCAAATTAAAAGttcacaaacgtacacatactggtgagaaaccatatgaGTGTGACGTCTGCGAACAGTCTTTCTCGCATTTCTGCAATTTAAATGttcacaaacgtacacatactggtgaaaaaccgctccagtgtgacgtttgtcagAAGACTTTCAGCCAATCGAGCAGTCTAATAAGACACAAACGTACTCATACAGGAGATacgccgtatcagtgtgacgtctgTGGAAAATTTTTCTCCTACTCGTGCGATTTGAATACTCACAAACGtacgcatactggtgagaaaccgtataaatGTGACATTTGCGAAATGTGTTTCATTACGAAAAGCGGTTTGATAAAGCACAAACGTAAACATATCGGTAAAAGACCGTATCAGTGCACCGTTTGTAAGAAGTACTTTTCACAttcatcaaatttaaaaaagcatAATCGTGcgcataccggtgagaaaccatatcagtgtgacgtttgtaaaaagtccTTTTCACGATCCGATGATTTAAATAGACATAATCGTacgcataccggtgagaaaccatacaagtgtgacgtttgtggaATGTGCTTTTCTCAATCAACTCAGCTAAAACGCCATAATCGCGTTCATACTGGGGAAAAACAATATTAG
Protein Sequence
MDDKLEENLSVHLNAGNKMNNVIFLKSEIKDEPIDDNALFPTDYAKKNSCEDTKIDVSDTKVGVETDFTWKETESATFNSTNEIDNGMSLKSEIKEEPVDDNSIFLTEYLECTINDPSDGEQTKITSKETISDFDHTSRNFSNLSSDGLTEYFDEYKEQTKSGISVNYETHQKPTKQKYHCEFCNKSFSKSCNLIVHRRTHTGEKPHQCDICEKSFSELGNLNVHKRTHTGEKLFQCDVCQKTFSRTSNFVRHKRVHTGDTPYQCEFCERSFSDSGNLNVHKRTHTGEKPHQCEVCQKTFSQASNFLRHKRMHTGVTPYQCNICEKSFSDSGNLNVHKRTHTGEKPHQCDVCQKCFNQAGDVIIHKRIHTGEKPYECDDCKKCFARSVDLKRHSRSHRGEKPYKCDICEKCFSRSSYLKVHSRLHTGEKPYECDVCKKCFPQTSSFDRHKTVHTGEKPYQCDVCKKCFPQSSNLDRHKRVHTGEKPYQCDVCKMCFPQSSNLDRHKRIHTANCADYIVRDAGEMSYEDTKIDVGDTKVSLNVDFKWHETTSTFSSTNERISIKSEIKIEPTVDNSFVFIPKYVDNENTTSNSKVSETSFEDAKADKKSGNFSILRSVEVTNNFDKCKEEYKSIIVNCEKHEKKNQEYVCEKSSANLIVRKRIHTGEKPYQCDVCKKRFTQAGSLTRHKRTHTDDTPYQCDVCENFFSGTSDLNTHKRTHTGEKPLQCDVCNKRFTQTGSLTRHKRTHTGDTSYQCDVCGKFFTNSSDLNAHKRTHTGEKPFQCDVCNKCFSQSSSLLVHKRTHTGDTPYHCDVCGKSFFNSFKLKVHKRTHTGEKPYECDVCEQSFSHFCNLNVHKRTHTGEKPLQCDVCQKTFSQSSSLIRHKRTHTGDTPYQCDVCGKFFSYSCDLNTHKRTHTGEKPYKCDICEMCFITKSGLIKHKRKHIGKRPYQCTVCKKYFSHSSNLKKHNRAHTGEKPYQCDVCKKSFSRSDDLNRHNRTHTGEKPYKCDVCGMCFSQSTQLKRHNRVHTGEKQY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-