Basic Information

Gene Symbol
ZFX
Assembly
GCA_947086425.1
Location
OX352222.1:1326794-1338801[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.00012 0.0066 17.1 4.7 1 23 5 27 5 27 0.98
2 16 0.0075 0.43 11.4 2.1 1 23 33 56 33 56 0.96
3 16 0.00093 0.053 14.2 1.5 1 23 63 85 63 85 0.97
4 16 6.6e-05 0.0038 17.8 6.9 1 23 91 113 91 113 0.98
5 16 0.00015 0.0088 16.7 3.8 1 23 119 141 119 141 0.97
6 16 6.6e-05 0.0038 17.8 0.8 1 23 148 171 148 171 0.94
7 16 0.0001 0.0057 17.3 4.6 1 23 179 202 179 202 0.96
8 16 2.5e-05 0.0014 19.2 0.7 2 23 209 230 208 230 0.96
9 16 0.001 0.06 14.0 1.3 1 23 236 260 236 260 0.96
10 16 0.00027 0.016 15.9 2.6 1 23 266 289 266 289 0.97
11 16 5.1e-05 0.0029 18.2 0.8 2 23 297 319 296 319 0.97
12 16 0.38 22 6.0 0.3 1 23 327 350 327 350 0.95
13 16 8.5 4.9e+02 1.7 1.4 2 20 357 377 356 381 0.86
14 16 1 58 4.7 3.9 1 20 829 848 829 851 0.91
15 16 2.5 1.4e+02 3.4 2.2 2 23 862 882 861 882 0.92
16 16 0.019 1.1 10.1 5.5 1 23 1004 1026 1004 1026 0.98

Sequence Information

Coding Sequence
ATGGCTAAACACTACAAATGTGATATTTGTAGTAAGAAATTCACTGACAAACAGTACTTAACTAGCCACAAGCATATACACACTATAGGCACACCGTTCAAATGCCAACAATGTCCGTACCAAGGCAAGACTAAGAAGTACCTAGCTCGGCACACAAAGCAGGTGCATAAAGATCTATCGAGGGAACATAAGTGCAATGTTTGCGGGAAGCTCTTTCTGCATCCGAGCAGCTTAAAGGTCCATGCTATGGTTCACTCCGGCGAGAAACCCCACAAATGCAAGTACTGCGACAAAACCTTCAGAGTCACGTATACTTTGAATATACACATGCATACACACACAAATGAGAAACCGTTTGCCTGTTCGTTCTGCGACTACGCATGTCGAGACAGCTCTACGCTTCGCAAACATCAGAACAAGCATATGGGATTGGAGAAGATATATCAATGCAAGATATGTAATAAGGGATGCAAATCTCGCGCTGCGTTGAAGATCCACATCGCGGAGACTCATCTCGAGCTGGATATGAAGAAGTTTCGATGTACCCACTGCGATAAGATGTTCAAGACTAATGCGCACAGGAAAACACATATTGAAGTGGTACACAAGCGGTCTCTAGTCTGCAACTGCCCTATTTGCGGGCGTCGTATCGTAAACAAGAACAATTTGGGTGCACACATGCGGACACATCTAGACGAGCGACCGTTTAGCTGCACGTATGATGGATGTAACGTTAAATTTAAGGATAAGAATTCTTTAACAAAACACAAAATAATTCACAATCCATCTTTACATTTCCCTTGTTCGTACTGCGGAAGGAAGTTTGCGAGAAAAACACATAAGAATGATCACGAGCGAGTGATGCATGTTGAAAGGATCAAGAATGTTGAGTGCGACTATTGCGGCTCTAAATTCTACACAAAGAACTACTTAATAAAGCACATACAAACTAAGCACGTGTATAAGCAAGTGTTCAAGTATATATGCGACACTTGCGGGCTCGTCACTCACAACAAGCCGAGTATAGTGATGCACCTCAAGTATGGACATAGTAACGATTACGACGTGCAATGTAAGATTTGCGACAATAAAATAGTTTACAAGAAGCATATGTATCTGAAACAACATTATTGGAAGACGCATAACATCAGATACAAGGTTACTAGGAAAGGATACAATCAATCAAGGAAAGAAAAAAATTCAGTAGAGGTGAAAGTTGAACCGATCGAAGCGGATTCATACGAAGAAATTCAGTTATTGGACATTGAAAAACATGAAAATGAAGATATAGAGGATTGTCTAGACTACTCTAAAAGCGTGTTATCAGAAGACATAGCTGCGTCGGTACTGAGGGCGGACAATAATGGAACTGAGATTGACTTTGACGAGTTCTTCGTTAGACATGTATTTGCTAAGCAGGAGAAAGCTACAGAAGAGACAAACACAGACGGCGTTAACACAGAACAGAACGAATACGTAAAGAATCGTATTAAGAAGATTCTTAAACGAACAGAGAAGATTGAGAAAGAGAAGGCATTACAGAAGAAGTTGGAAGAAGAAGAGAAAGATAGAGTTAAGAGAGAGAAGGAAAAGGCGGTGGAGCAAGCGAAGAGAGAGAGAATGGAGTTGGAAGAATTGAGGAGAGTAAGAGAGATGTATAATGAGAGGATGGCAGCGGCTTTGAAGAGGGAGAAAGACAAAAAAGAAAAAGTGAAAATAAAGTACTTTAAAAAGATTACTGAAACTTCCAAAAGTACCAAAAACGCAGAAGAAATGTCTGAAAATTTGAAAGACGGTAATGTGGTTCAAGAAAATGTTGGTAAAGATATTGAAAATAGTGATTTAAATAATTCTAAAGAAACTGATTCAATTGAAAGCAATGCTATTGATAAAACACAAGAAAATAATGACCTTGGTAATGAAAATGAATTTCAAAACAGTAATGTCATTCAACATAACATAAGTGAGAATGATTTTGAAATAAATAATGACGAAGGTGAAGATTTAATAATTAAAGATAAACAAAAATGTGATTTAGATAACAAATTCATTGATGATAATGATATAGTACTTGAAAATACTCGTAAAAGTGAGGAAAATAATCATAATGATGATGATGAAACTAATATCAATGAGAAATACAATGATGTTGATAGCAAAATTGATAATGAAAACGATACAAATGAACAGAAAATTCAAAGAAATATAGATACAGAAGAAATTATTAATGATTTTAGTGATGTAATTGATATAAATAATGATAAAACTAATAAAAATGAGCAAAACGTTAAAATAAATAGTGAAATTAAAGAAAATAATGAAAGTAACAAAGATTTATTAAATAATACAGACGGACAAACCACAAGTGATGATGATCAGCCGTTACTTGAACGAAGGAAAAGGTTTAAAAGAAAGATAACAAAGACAAAAGTTGAAAATGTTGATATTAATAACAAAAAGTCGAAGAAAATAAATTTCATGACGTACCAATGTTATGTTTGTTTTAAGTTGTATCAAACAAAAGAAGAGTTGACTACACATTGTCAAGAACACTTTGACATCTGTCATACTCGTATGCTCAGTAAATGTCCACTTTGCGATCACGTAAGCCACAAAGGTCTCGCCAAACATATGAGAATAGAACACGATACCGAATTAACAACACTACACAACACATTCCGGGACAACAAAGGGGACGGCTCAGGGTACAATTATAACATCAACGGGACAATAATACAAGTCATACCTAGTGTTAATGCTCTTAATAAAACCGCTAGCAATAATATCGATAAAGTTAGAAGAGATTTAAAAGACAAAGTTATTTCAAAGTCTAAGTTAGTTAAGAAAGGTAATGAATGGATTGTTGAGAAAGAAAGAATAGCTATAGAATTTGATGTTATACCAGAATTAAATGATAGAGAGTTAAGCAAACTTAAAGTAACGGAGACAGATGTTGATAGACTTGGACAGTTAAGTTACATAGTAAAGAAAAAAGGTCTAAAAATGATGTTCCCATGCTTTCATTGCGAAAAAATATGCCAGAATTTCAGCGGTCTTAAGCTACATCAAAGAAGACACGAAGCCAATCCTAAACCATTTAAACCTAGAGTTAAAAGGTCAGACAAAATAGTTAAAGATACAAAAAAGATTAAACTAGACAAAGGTAACAGACACGCATTGCCTAAACCAATTTTGAATAAACATAAATGCGATGATAAACTTAAAAAGTTCTTTGAAAGTAACATAAGAGGGGGTGATATAGAGTTTTGGCAGTTTTTAAAGATTTACAACAAAATGAATAAGGAGAAAGTTAATGATTTTAAAGATTTGGAAAAGAGAACAGATTTTGGTAATCATTTGGATTATTACAAAGATAAAAATGATGATGTTCAAGATTCTAGTGATGAGTAG
Protein Sequence
MAKHYKCDICSKKFTDKQYLTSHKHIHTIGTPFKCQQCPYQGKTKKYLARHTKQVHKDLSREHKCNVCGKLFLHPSSLKVHAMVHSGEKPHKCKYCDKTFRVTYTLNIHMHTHTNEKPFACSFCDYACRDSSTLRKHQNKHMGLEKIYQCKICNKGCKSRAALKIHIAETHLELDMKKFRCTHCDKMFKTNAHRKTHIEVVHKRSLVCNCPICGRRIVNKNNLGAHMRTHLDERPFSCTYDGCNVKFKDKNSLTKHKIIHNPSLHFPCSYCGRKFARKTHKNDHERVMHVERIKNVECDYCGSKFYTKNYLIKHIQTKHVYKQVFKYICDTCGLVTHNKPSIVMHLKYGHSNDYDVQCKICDNKIVYKKHMYLKQHYWKTHNIRYKVTRKGYNQSRKEKNSVEVKVEPIEADSYEEIQLLDIEKHENEDIEDCLDYSKSVLSEDIAASVLRADNNGTEIDFDEFFVRHVFAKQEKATEETNTDGVNTEQNEYVKNRIKKILKRTEKIEKEKALQKKLEEEEKDRVKREKEKAVEQAKRERMELEELRRVREMYNERMAAALKREKDKKEKVKIKYFKKITETSKSTKNAEEMSENLKDGNVVQENVGKDIENSDLNNSKETDSIESNAIDKTQENNDLGNENEFQNSNVIQHNISENDFEINNDEGEDLIIKDKQKCDLDNKFIDDNDIVLENTRKSEENNHNDDDETNINEKYNDVDSKIDNENDTNEQKIQRNIDTEEIINDFSDVIDINNDKTNKNEQNVKINSEIKENNESNKDLLNNTDGQTTSDDDQPLLERRKRFKRKITKTKVENVDINNKKSKKINFMTYQCYVCFKLYQTKEELTTHCQEHFDICHTRMLSKCPLCDHVSHKGLAKHMRIEHDTELTTLHNTFRDNKGDGSGYNYNINGTIIQVIPSVNALNKTASNNIDKVRRDLKDKVISKSKLVKKGNEWIVEKERIAIEFDVIPELNDRELSKLKVTETDVDRLGQLSYIVKKKGLKMMFPCFHCEKICQNFSGLKLHQRRHEANPKPFKPRVKRSDKIVKDTKKIKLDKGNRHALPKPILNKHKCDDKLKKFFESNIRGGDIEFWQFLKIYNKMNKEKVNDFKDLEKRTDFGNHLDYYKDKNDDVQDSSDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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