Xspa005554.1
Basic Information
- Insect
- Xanthorhoe spadicearia
- Gene Symbol
- ewg
- Assembly
- GCA_947086425.1
- Location
- OX352196.1:1196872-1215986[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 8 1.7e-50 1.8e-46 158.8 0.5 1 101 181 281 181 284 0.98 2 8 3.2e-10 3.3e-06 27.2 0.0 66 101 281 316 278 319 0.90 3 8 3.2e-10 3.3e-06 27.2 0.0 66 101 316 351 313 354 0.90 4 8 3.2e-10 3.3e-06 27.2 0.0 66 101 351 386 348 389 0.90 5 8 4.3e-10 4.5e-06 26.7 0.0 66 100 386 420 384 423 0.91 6 8 3.2e-10 3.3e-06 27.2 0.0 66 101 421 456 418 459 0.90 7 8 3.6e-10 3.8e-06 27.0 0.0 66 101 456 491 454 494 0.91 8 8 2.4e-66 2.5e-62 210.6 0.0 66 212 491 644 488 645 0.93
Sequence Information
- Coding Sequence
- ATGGTGGAAAGTGCATACAAAAGGATACATGCGACTGCTCCAAGGGTTACTATGGAAGGAGCAAAATGCGTGATCCCATGCCTAGGCGGGGGTCGATGCAAGGGCGTGAACAAATGCCGGTGCCCGGCGGGACTCGGCGGGAACCACTGCGAGGTGGGGCGCCGCGGGGGCGAGTGCGGGCGCGCCTGCCGCCACGGACGCTGCCAGGGAGGCCTGTGCGCCTGCGAGCCGGGCTGGCGCGGACGGTACTGCCATAGGTCCACAGGCAGCAGAGTGTGTTCCACCACGTCGTCCCCAACGGAACTTGAATCAATGGTCCTAGACAGGGACCAGGGAGAAGACAACATGAACTCTGCTGTCAGCACCGAGTCCATGGACATCGGAGATGAGGAGATGTCCCAAGTGGAAGGTTGCGGTCTGAGCGGTGGTTCTGACGACGAGGACGAGTGCGTGTCGTCGCCCGCAGCCTCCAACTACGGAGACGAGGAGATGCGCAAGAGCGCCATGAGCGACGAGGTCACCAAGACACTGGCCGCTGCCGGTCCAGTGGGCATGGCCGCGGCGGCCGCGATAGCATCCTCCAAGAAACGCAAGCGGCCGCATTCCTTCGAGACCAATCCATCTGTCAGGAAGCGTCATCAGAACAGACTGCTTAGAAAGTTGAGGCAAACGATCGAGGAGTTCGCAACCCGCGTGGGGCAACAAGCCGTGGTGCTGGTGGCGACGCCGGGCAAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGCCCACCGCCTCCTACCGCGTGTTCGGCGCCAAGCCGCTAGAGGACGTGGTGCGCAACCTGCGCTCCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCACCAGTTCGGGCTGGGCGGGCACGGGCAGGCGCCGCCGCCGCCGGCCGAGGACCCCTCTCTGTTCGAGCTACCGCCGCTCATCATCGACGGCATACCCACGCCCGTCGAGAAGATGACGCAGGCGCAGCTGAGGGCATTCATACCGCTCATGCTCAAGTATTCTATGGTGCGTGGCAAGCCAGGCTGGGGTCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAAGACCTGCCCTGGGCCAACGTGCGCATGGACGCGCGGACAGACGACGAGAAACAAAAGatgtccTGGACCCACGCGCTGCGTCAGATCGTTGTGAATTGCTACAAGTTCCACGGACGCGAGGATCTCTTGCCAGCGTTCAATGAAGACGAGGACAAgacaccaacctccTTGGCTTGCCTGGAGGGCTCGAGCTCGCCGGCGCGCGCGCTCGAGCACGAGCCGCACGAGCACGAGCTCGAGCACGAGCCGCAGCAGCAGGCCGTGCTCACCACGCAGCAAGTCTGCATCGATCAGATGACGCTCTCTGATGTTGAAAACATGCAATACGCGCCGGCAGTTCTTCACTCGATCACGAACCCCGATGGTTCTGTCTCCATCCTCAACTTGGACCCCAACAACCCGATCATAACGCTCCCAGACGGCACCACGGCGCAGGTGATCCACACTGGCGAGGTGGGCGCGGGCAGCGTGGTGCAGACGCTGGATGCTGACGGTAACGCGGTCGCGCTCGACATCAACTCCGTGGAGGCGCTCTCAGACAACCAGATCATCATCACCGGGGAGGATGGAGAGTGTCGTCCGCTGTCGCAAGTGGTGACGCTGCCGATGTACCAGCAGATGGTGGCGCAGATGGCCGGCGGCGACGGCGTCTGCGTCACGCCGCTCGTGCAGGTGGACCAAAACGGTGACACTATAGAGACCATCTCGATGGGCGGCGGGGTCGCGCAGATGATGATGAGCTCTGATACGCAAGTGTTGCAAGTTCTCAGTCTCAAGGATGCTACCGTACTCACTAAGGCTATGAACGTGAAATCGGAGCGTGAGACCGTCGTGACGGATTCCTAG
- Protein Sequence
- MVESAYKRIHATAPRVTMEGAKCVIPCLGGGRCKGVNKCRCPAGLGGNHCEVGRRGGECGRACRHGRCQGGLCACEPGWRGRYCHRSTGSRVCSTTSSPTELESMVLDRDQGEDNMNSAVSTESMDIGDEEMSQVEGCGLSGGSDDEDECVSSPAASNYGDEEMRKSAMSDEVTKTLAAAGPVGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQPTASYRVFGAKPLEDVVRNLRSMIMEELENALAHQFGLGGHGQAPPPPAEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARTDDEKQKMSWTHALRQIVVNCYKFHGREDLLPAFNEDEDKTPTSLACLEGSSSPARALEHEPHEHELEHEPQQQAVLTTQQVCIDQMTLSDVENMQYAPAVLHSITNPDGSVSILNLDPNNPIITLPDGTTAQVIHTGEVGAGSVVQTLDADGNAVALDINSVEALSDNQIIITGEDGECRPLSQVVTLPMYQQMVAQMAGGDGVCVTPLVQVDQNGDTIETISMGGGVAQMMMSSDTQVLQVLSLKDATVLTKAMNVKSERETVVTDS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -