Basic Information

Gene Symbol
hang
Assembly
GCA_949129095.1
Location
OX422143.1:115909564-115920745[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.041 17 8.4 1.3 3 23 264 285 263 285 0.93
2 18 0.016 6.9 9.7 2.7 1 23 455 478 455 478 0.91
3 18 4.4 1.9e+03 2.0 2.2 3 23 519 540 517 540 0.90
4 18 0.0015 0.64 12.9 1.7 2 23 585 607 584 607 0.95
5 18 0.0039 1.6 11.6 0.1 1 23 615 638 615 638 0.95
6 18 2.8e-05 0.012 18.3 0.1 2 23 736 757 735 757 0.97
7 18 2e-05 0.0084 18.8 2.5 2 23 801 823 800 823 0.96
8 18 0.0042 1.8 11.5 0.3 2 23 832 854 831 854 0.95
9 18 0.00074 0.31 13.9 0.2 1 23 867 890 867 890 0.97
10 18 0.00032 0.13 15.0 1.0 1 23 920 942 920 942 0.99
11 18 0.0013 0.57 13.1 0.9 1 23 950 973 950 973 0.96
12 18 0.0072 3.1 10.8 0.3 2 22 981 1001 980 1001 0.93
13 18 5.2e-05 0.022 17.5 0.8 3 23 1070 1090 1069 1090 0.98
14 18 2.4e-05 0.01 18.6 0.1 1 23 1125 1147 1125 1147 0.98
15 18 0.00027 0.11 15.3 0.3 2 23 1172 1194 1171 1194 0.93
16 18 0.12 51 6.9 0.3 2 19 1214 1231 1213 1233 0.93
17 18 0.0054 2.3 11.2 0.5 3 23 1249 1269 1249 1269 0.98
18 18 0.0083 3.5 10.6 0.2 2 23 1420 1441 1419 1441 0.96

Sequence Information

Coding Sequence
ATGACAGAAGAATCAATACTACGTGCACGTCAAAATTGCTGTCGCTTGTGCTTGGCTCCGGACAGTGAATGTATTTCGATTTTTAACAGCTATGCGGCTGATAAGGAGCCTCTGGCTACCAAAATTCAATCATGTGTCAATATTAAGATATCGCCGATTGACAGGCTCTCGCTGCGAATATGTCACGCTTGCATCAGTTACTTAAACTCATGGCAGAGTTTCAAGAATCGCTGTGTGGCATCACAGAACAAACAACGCAGCTGGTTGGAGATTTCCAAGAAAATGGACAGAAAGCAAATAAGTTCAGCTATTTCAATATCAACTGTTGTAGATGGTGGAGGAGGTGTAGGCAGCGGCGGCGGAGGCGGAGGAGGAGTAGGAGTAGGAAGAATAACAAGTCATGACGTAGAGGAACAAGATAATAGCCAGCTCGCCAGCTCTATACTGGAAGGAATTTCATCACTCAAGAAGAGACGTTCCTTAACCGTCTACCCAATTCCGGTGAGTATCAAGGATGAGCCAATTGAAGATGACGACTATGATCCAAAACATGATGAGTCAGATATTGATCCAACACTCTTTTTGGACCGCACTGAGGAGGAGGGCTCGGATAATTTGTCACAGAAAGAACAACATTTGGCTTCGTTGGGGTTGAAGCAAGCTACCGGTCCTGTACACCCGTTGAGCTATTTGgctGACTACAGTTTCGAGGGAGAAAGGAGTTCTCAGACGCCAACGGACAAATCCCTAGAAATCATCACCGCCAGCAGTGAAGTAAAGGAGGCCTCATGTCGTGCGTGTAATCTGAAATTTTCCACAAGAGCAAATGCCCGCCGTCATGAGCGTAACTTACATCCGCACTTATTCACAAGTATTCCACATAGTACAACATCATCCAAAGCGCTCACTGTATTAAATCCCTTGGCACTCGGCGTCAAAGGAGGACAAGTAATTCGTCCTTTAATTCAACCCGAATATCTTGGTCATTTTGATTACGATCAACCGGAAAAGTATCAGCATCTCCTCTCGGaggataaaattttatttatgcaGCGCCATGATGACTTTCTACAACAATATCAGAATATGACGTGTAACTGCTGTTTACGTACACATGcaacatataaaaattttatggcACACATGCGAAAGAAGTATCATACTCTGCCACGTAATCTTTGCTTTAAATGCCTCAAACAAAACGACTCGAAAGCTCTATTCATATCGCATCTGAAGAAACGAAACTGTATTAATCTGTACAAGGTTTACCATAGTCTAATTGATGCAGGTGTACTAAAAAAAGACGCATATAGCTGTTTACCTGACAAGCTGCGTGCTAAAGAACTACTGGTTAATAAAATCTACGAATGTAAGATATGCTCCAAACATTTCCGGTTGAAGCTGGAGTTTCGCAGTCATGTTTATGAAGAACATGCTGAATACCAGAAGAAAGATGTTTCACCGGGTCACTGTGGCTTTTGTGGGTTAGAAATCGAAGATCCTTTCGAACGCAAACGTCACTACAACAATATGGATTGTATTGTTATCCTACGATGCATCACATGCGATGAAAAATTCGACAACCATCAGAAATTTTTGGATCATGTATATACAAAGCACTTAGCGAACAACAACGAAATACAAAAGAGTAATCTGATGAAAGAGCTTTCTTCTGCAACGTCTACAGAAAGTTCGCCTTCGAAGAAATCTGAAACAACTTCAAAACCGCAGTTCTTTTCACGTCTACCTCAGAGTTGTAATATTTGCGGTCAACATtacaataattacaataatgtTTTGCGTCATATGGAGTCGAAGCATCCTGATCAGCTGCCCCAAACTTACAAATGCACACGGTGCTTGGTGGGTTTTCCACGTCTGATGAATCTTCGTGAGCACATGATTGAAGTACACGGAATGAAAGTCGATAAAGTGCGCAATAATAGTTTCGATTATATTGTGGACTCACCAACCGTACAAGCAGGTACGCAACGGGGACAGGAAAAGATATCCGCTGATGCATATAGTGGTCGGTACGATTACGTGATGAAAGACTTAATGTCGATAACAAACGGTGGCACAATAGGCACCGAAAATGCCAATGAAAATGAAGACGATGACAATCTGTCCGACTCGCCGAATGCAAAGAAACTGAAACTTGACAGTGGTGGCACTATAATGGCTGTTGGCACTGCAAGTTTAAAAGAATGCCCCATCTGCAGCGCTGTCTTTAATAACAATATTGGTCTTTCCAATCATATGCGTACTCATACTATGGGAGAAGGTGGTGTAGAGATTACCCTGCCAGAGGAGGATAGCGTTGTTACAGAAAAGAAATCGATGGATCCTCTATTTAAGAGAAGTTTAGAACTAGCAGCGGATCGACGATTCCGTCGTATGCGATGTAGAATATGTCAAAAACGCTTTTCATCTAAAAAAAGCTACCGCCGCCATATGCTAATCGATCATCAAATTCGAAACGTGCAGTTTATCAAATGCAAACTGTGTAACGCTGAGTTTGCCTACGAAAAGGGCCTCAAGGTGCACATGTTCAAAATTCATAACACGTTGCTGAAGGATGAGATGATTGTTAAGCAATACGAGTGCGACATTTGTTCCATCGTGTATCGGACCGAGGAACAATTGCTAATGCATAAAAAGTCAGTTCATGGAAATGAATGCGCTCACGCTGAAGATGAACTTCCGCCATCAGTGGAACAAAGCAtggaagcaacaacaacagcaccgtTCTATTGGTATCAGTGCCGATATTGCCCTTCTAATTTTAACACGAACAAGAAACTTGCCATTCACATAAATTCACATTATGAGTTTGATTCGAATGATTATTCCTGTAAGGACTGTGGTAACGTGTACAGTGGTAGGAAGAGTCTTTGGGTACATCGCTACAAGAAACATCCTCCTGTGGCTGATCCCTCTCAGTGTTTGATTTGCAAGAAGATATTCTTTGACAAACAAATGCTGGAGAATCATGCACAGACATGTTTTAAAAAAGGTAGTGCTGGTGGCGCACCTGAATCTGAGGTATCCACTTTCTTCCAACATAGAACAggcgatgatgaagatgatgagaaTGATTTGCAGCAGCCAcagcaaaatcaacaacaacagcagcagcaaccacaacatGTTGCTTCCGAGGAAAGTACGacgacaaatttaaaaattaaattacccgAAGTCGCCTGTACGATTTGTTCGCAAAAATTCACTGATCAGGAGCTCTTCACAAAACACATTCAGATGCACGAAATGGAATTGTACACCGACAATCCCCTGGCGGCTATGTTCGACACAGGACCAGCTGATCCgaatcaattttatttggattgtgtcaatgacaatggGGAATACGTTTGCGATATTTGCAATAAGGCATTTGCTCAAATGACAGCACTTAAAGTCCATCGCAAGTGGCATTTTCGAGGTGATAGCAAACAGaCTCCAGCCGATGTAAACGCGCCAAAAACAGTGAAACGCAAACGTGAACTTAAATGCGATTATTGTCCATCGACGTTCATTAGTACAAACAACCTTAGACGTCACATAGCTGAACTGCACAAATCAGAAATATCTAATTGGCCAGAACCACcaaaaattgaaaccgaaaaGTACCTCCAATGTAGCAAATGTGAACTGAAATTTGATACCAAGAAAGATTGGATAGAGCATAAAGTAAATGAAGCCAAAATTACCAAACCGTTTGGACCATTCCAATGGGGCTGTGACATTTGTGGTGTGTATTTGTCGCGCCGCGAGAAGCTCATACATCACATGATGGCACACATGAAAGAAACGAACGGCCAACTGAGCGTAGAAGGTGAAAATTTCCCTGGGGAGAGTAATTCACAGGATTCCGAATTGTTTAATCATCAAGAAACATCTCAACAACGTCAAatcgacgaagaagaagaagatgatgaggaagaagaagaagagtatGACGGAGATGGGGATGGGGATGGGGATGGGGATGGAGATGGAGATGGCAATGGCGATGTAGATGAAGAGGACGCCGAAGACACCGCCAATACAGTCAATCATGACGATAATGCTAATGATGGGCAAAACGACGAAGACACGGAGCAGAATTCCCACCTAAGAGAGCGGCTTGAACGTGAGTCGAACGACGACAGCAGTGACTCAAGTGACCAGAGTTCAGACTCTGATGATTCCTCATCTGATGAAGACGATCAGGAAGCTCATTCTCCCCAGGAAGAACTTCAAAAACGGTCTTCATGTGATCTTTGTCAAGTTTACTTTGGTACATCAGCGGAGCTACAGCGCCACGTCACTAGTCATTTCGTTAATGGACCAGGTTCTGTAACACTCACCAGCATAACCAATAACAAGGCCGAAGTATCAAAAATTCATACAAAAGATAATGAtgacgacaacgacaatgacaatgacgacgatgacgacgatgatgatgacatgACCGAAGCAGATGGACTAGAGTCTTAa
Protein Sequence
MTEESILRARQNCCRLCLAPDSECISIFNSYAADKEPLATKIQSCVNIKISPIDRLSLRICHACISYLNSWQSFKNRCVASQNKQRSWLEISKKMDRKQISSAISISTVVDGGGGVGSGGGGGGGVGVGRITSHDVEEQDNSQLASSILEGISSLKKRRSLTVYPIPVSIKDEPIEDDDYDPKHDESDIDPTLFLDRTEEEGSDNLSQKEQHLASLGLKQATGPVHPLSYLADYSFEGERSSQTPTDKSLEIITASSEVKEASCRACNLKFSTRANARRHERNLHPHLFTSIPHSTTSSKALTVLNPLALGVKGGQVIRPLIQPEYLGHFDYDQPEKYQHLLSEDKILFMQRHDDFLQQYQNMTCNCCLRTHATYKNFMAHMRKKYHTLPRNLCFKCLKQNDSKALFISHLKKRNCINLYKVYHSLIDAGVLKKDAYSCLPDKLRAKELLVNKIYECKICSKHFRLKLEFRSHVYEEHAEYQKKDVSPGHCGFCGLEIEDPFERKRHYNNMDCIVILRCITCDEKFDNHQKFLDHVYTKHLANNNEIQKSNLMKELSSATSTESSPSKKSETTSKPQFFSRLPQSCNICGQHYNNYNNVLRHMESKHPDQLPQTYKCTRCLVGFPRLMNLREHMIEVHGMKVDKVRNNSFDYIVDSPTVQAGTQRGQEKISADAYSGRYDYVMKDLMSITNGGTIGTENANENEDDDNLSDSPNAKKLKLDSGGTIMAVGTASLKECPICSAVFNNNIGLSNHMRTHTMGEGGVEITLPEEDSVVTEKKSMDPLFKRSLELAADRRFRRMRCRICQKRFSSKKSYRRHMLIDHQIRNVQFIKCKLCNAEFAYEKGLKVHMFKIHNTLLKDEMIVKQYECDICSIVYRTEEQLLMHKKSVHGNECAHAEDELPPSVEQSMEATTTAPFYWYQCRYCPSNFNTNKKLAIHINSHYEFDSNDYSCKDCGNVYSGRKSLWVHRYKKHPPVADPSQCLICKKIFFDKQMLENHAQTCFKKGSAGGAPESEVSTFFQHRTGDDEDDENDLQQPQQNQQQQQQQPQHVASEESTTTNLKIKLPEVACTICSQKFTDQELFTKHIQMHEMELYTDNPLAAMFDTGPADPNQFYLDCVNDNGEYVCDICNKAFAQMTALKVHRKWHFRGDSKQTPADVNAPKTVKRKRELKCDYCPSTFISTNNLRRHIAELHKSEISNWPEPPKIETEKYLQCSKCELKFDTKKDWIEHKVNEAKITKPFGPFQWGCDICGVYLSRREKLIHHMMAHMKETNGQLSVEGENFPGESNSQDSELFNHQETSQQRQIDEEEEDDEEEEEEYDGDGDGDGDGDGDGDGNGDVDEEDAEDTANTVNHDDNANDGQNDEDTEQNSHLRERLERESNDDSSDSSDQSSDSDDSSSDEDDQEAHSPQEELQKRSSCDLCQVYFGTSAELQRHVTSHFVNGPGSVTLTSITNNKAEVSKIHTKDNDDDNDNDNDDDDDDDDDMTEADGLES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01522849;
90% Identity
iTF_01522849;
80% Identity
-