Basic Information

Gene Symbol
topi
Assembly
GCA_951394055.1
Location
OX596023.1:4831101-4835385[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 3.9 4.8e+02 2.7 2.4 1 20 119 137 119 139 0.89
2 11 8.4e-06 0.001 20.6 2.6 1 23 220 242 220 242 0.97
3 11 0.0012 0.14 13.8 2.0 1 23 295 318 295 318 0.96
4 11 0.01 1.3 10.9 0.2 2 23 388 409 387 409 0.95
5 11 0.0052 0.64 11.8 1.1 1 20 455 474 455 479 0.92
6 11 0.18 22 7.0 0.1 2 23 494 516 493 516 0.90
7 11 1.4e-06 0.00018 23.0 2.0 1 23 534 556 534 556 0.95
8 11 0.0007 0.087 14.5 0.8 1 23 562 587 562 587 0.95
9 11 0.46 57 5.7 1.5 1 23 593 615 593 615 0.88
10 11 4e-06 0.0005 21.6 0.6 3 23 623 643 621 643 0.98
11 11 0.00045 0.056 15.1 1.0 1 23 649 672 649 672 0.95

Sequence Information

Coding Sequence
atggaACAAAATTGGAACGATTTTAATGCATCACTTTTGACCGAAGATTACAATAAGGAAAATGAATGCAGTATAAACTACaacttaaataataaaaatttaaaaattttccaatttaatGGTAATAAACTAACAGAAAATGATTGTTATTAtctaaaagaaaagaatatttcTTCGTATCAAGATTTAAATGCTGTTAATAACAATGAAGAAAATATTGTATCCAGTACATCGAAAGAGAATGAAATTACCGATTTACATACAGAACCAAATTTATTGGTGAGATTTTCGGATGAAGATTATGAAATCAACgaaaattcaatatttgaaCAAGCAAATGAAAAaccaattttatatttatgcaatAATTGTTCCCAATATTTCGATAGATATAGTTTTGAACAGCATGTTTGTGAATATAATGAACATCAACGTTATATATTTGATGAAGAtattgaagaattaaaaaatttagaaaatgatgAACATCCATGTAAAAAacaattgaatgaaaatattgaattaacaaattttattttaaaaaataatttcaaaattgataTCAGTAAATATGGTTTGAATAAAATCAATGATGGTAATCGAAATAATTTGACAGCATCTGGAACAGTatcaaaatctaaaaaatcGAATGGACCACATGAATGTACAATATGTGAAAGAAAATTTGTTCATGCATCCGGTTTAAATAAGCATATGGAAAGGCATGATTTAGATTTTGCAACTACATCATTATCAAATGTATCAGCAACAAGAAAAGGAATAAAATCTATAgaatcatcaacatcatcatgtATTGGAACACAAAATACAAAtggaacaataaaaaattcattagaaTTGGGAAAGGGTCTAAGAATTGTATTTAAATGCAATTATTGTGGTCGAATAACGTTTGATCAAACTAATATGatgattcatttaaatcatgatcatgaaaatatattatttgaagttgaagatgataatgaaattgatttaccattggaaaaattaaatgaatttacaaataaattcagTTTATATGATGGTAATGTAACAGAAATGAATGAagatcaaaataatataatcgtatatgatgatgatgatgatgataatgatgatgatgttctATATAAAGTTTGTATCCTTAATACAGTATTACAATGTGAATTTTGTGATTGGTTTTATTCAAATGTAGATGATTTATTGATACATTCAACTAAACATAATCCATCATACAGttatgaatgtacattatgtaatatttgGATGAAAACATATAAAGAAATATTTCTTCATTGGCAATCTGATTGTCTTAAAAAACGTgatgaattaaagaaaaattggaatacacaaaaatattttgtatgtaatgtttGCGATAATAAATACAGTACAAATGAAAGTTTATTTGAACACAGatatttaaattatcatttttatccacgtttgaataaaattttaaatatttatcaaatatCATGTGAATATTGCGGTTTATTATTTGATAATGCAAAAGCAATAATGACACATTATACTGAACAgcattcaaaaaaatcaaatctaaaaaaagaacaaaactCAACAAGAATTAGACAATTCCTGTGCGATGTTTGTGGAAAATCTTATACACAATCAAGTCATTTATGGCAACATTTAAGATTCCATAAAGgTGTTAAACCATTTGCATGCAAGGAACCAGGATGTGATAGACGTTTTACAATTAGACCAGATCTAAATGATCATATTCGTAAATGTCATACCGGTGAAAGACCATATCATTGTGTTGTTTGTGGTAAAAGATTTTTAACTGGTTCAGTTTTTTATCAACATCGTTTAATACATCGCGGTGAAAGACGTTATGGCTGTAATGAATGTTCAAAACGTTTTTATCGTGCTGATGCATTAAAAAATCATCAACGTATTCATACTGGTGAAAAACCATTTCCATGTACAGTTTGTTCAAAACGTTTTCGACAACGTGGTGATCGAGAAAAACATGTAAAGGCCAGACATAGTAATGCAGAAGCATCTGCTAGAGTTATGCAAAGTATGAGAAATATTACTgctaatacaaatacaataaatgatgaaattgttgaaaaaaattgcagtactAATACTGTACAAAATGATGATTCACAACATGTTGTTTATGTGGCTAATTTACCATTTCCATCAAGTATGTTTAAGCCAGTTGTAACAGATATTGATTCtggtttaatttaa
Protein Sequence
MEQNWNDFNASLLTEDYNKENECSINYNLNNKNLKIFQFNGNKLTENDCYYLKEKNISSYQDLNAVNNNEENIVSSTSKENEITDLHTEPNLLVRFSDEDYEINENSIFEQANEKPILYLCNNCSQYFDRYSFEQHVCEYNEHQRYIFDEDIEELKNLENDEHPCKKQLNENIELTNFILKNNFKIDISKYGLNKINDGNRNNLTASGTVSKSKKSNGPHECTICERKFVHASGLNKHMERHDLDFATTSLSNVSATRKGIKSIESSTSSCIGTQNTNGTIKNSLELGKGLRIVFKCNYCGRITFDQTNMMIHLNHDHENILFEVEDDNEIDLPLEKLNEFTNKFSLYDGNVTEMNEDQNNIIVYDDDDDDNDDDVLYKVCILNTVLQCEFCDWFYSNVDDLLIHSTKHNPSYSYECTLCNIWMKTYKEIFLHWQSDCLKKRDELKKNWNTQKYFVCNVCDNKYSTNESLFEHRYLNYHFYPRLNKILNIYQISCEYCGLLFDNAKAIMTHYTEQHSKKSNLKKEQNSTRIRQFLCDVCGKSYTQSSHLWQHLRFHKGVKPFACKEPGCDRRFTIRPDLNDHIRKCHTGERPYHCVVCGKRFLTGSVFYQHRLIHRGERRYGCNECSKRFYRADALKNHQRIHTGEKPFPCTVCSKRFRQRGDREKHVKARHSNAEASARVMQSMRNITANTNTINDEIVEKNCSTNTVQNDDSQHVVYVANLPFPSSMFKPVVTDIDSGLI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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