Basic Information

Gene Symbol
-
Assembly
GCA_905340365.1
Location
HG996528.1:1547474-1556338[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 31 7.2e-06 0.00044 20.2 1.0 1 23 248 270 248 270 0.98
2 31 0.0031 0.19 12.0 1.9 1 23 293 316 293 316 0.96
3 31 0.00016 0.0095 16.1 0.5 2 23 323 345 322 345 0.96
4 31 0.0069 0.42 10.9 1.1 2 21 366 385 365 386 0.92
5 31 0.00024 0.015 15.5 0.1 2 23 484 505 483 505 0.96
6 31 0.0047 0.29 11.4 0.5 1 23 511 534 511 534 0.91
7 31 0.00014 0.0084 16.2 0.1 1 23 607 630 607 630 0.96
8 31 0.017 1 9.7 0.7 1 23 636 659 636 659 0.96
9 31 0.071 4.4 7.7 0.8 1 23 672 694 672 694 0.97
10 31 2.9e-05 0.0018 18.3 0.6 3 23 740 761 738 761 0.96
11 31 0.14 8.5 6.8 3.3 2 23 824 847 823 848 0.92
12 31 6.5 4e+02 1.5 0.0 2 23 857 879 857 879 0.83
13 31 0.018 1.1 9.5 0.1 2 23 886 908 885 908 0.95
14 31 1.5e-05 0.00092 19.2 1.2 1 23 916 938 916 938 0.98
15 31 1.1 68 3.9 0.5 3 23 972 994 970 994 0.85
16 31 0.00024 0.015 15.4 3.3 1 23 997 1020 997 1020 0.97
17 31 0.00052 0.032 14.4 0.2 2 23 1027 1049 1026 1049 0.95
18 31 0.0011 0.065 13.4 3.9 1 21 1076 1096 1076 1097 0.95
19 31 0.0031 0.19 12.0 1.8 2 23 1111 1132 1110 1133 0.93
20 31 0.51 31 5.0 1.4 1 23 1136 1159 1136 1159 0.94
21 31 0.0081 0.5 10.6 0.7 2 23 1166 1189 1165 1189 0.91
22 31 3.5 2.2e+02 2.3 0.2 2 23 1197 1219 1197 1219 0.94
23 31 4.2 2.6e+02 2.1 0.0 2 23 1226 1248 1225 1248 0.87
24 31 0.26 16 5.9 2.7 2 23 1257 1279 1257 1279 0.96
25 31 0.92 57 4.2 0.7 2 23 1285 1307 1285 1307 0.92
26 31 0.22 14 6.1 2.0 1 23 1370 1393 1370 1393 0.95
27 31 0.0013 0.08 13.1 2.7 1 21 1422 1442 1422 1443 0.95
28 31 0.37 23 5.4 1.9 2 23 1544 1566 1543 1566 0.94
29 31 1.7 1e+02 3.3 1.0 2 23 1573 1595 1572 1595 0.94
30 31 0.8 49 4.4 2.5 1 23 1606 1628 1606 1628 0.97
31 31 0.65 40 4.7 0.2 3 21 1637 1655 1635 1656 0.94

Sequence Information

Coding Sequence
atgacgacgacgacaacgacgacgacgacgacgacgacaacgacgacgacaacgacaacgacgacgactacgatggAGTCTAGGCAACGTTATCACGAACTCTGCCGATTGTGTGCATCTTACGACGCTGTCAAGATGGATATATTCGGTCAGGAAGGGAAAAATCGACAACTCGTCGACAAAATTCAGACCTGTCTACCGTTCAAGatcACAGAAAATGATCGTCTGCCAAAGTGTTTATGTTATCGCTGTATGTACAACCTGGAGAATTTTTATGACTTCAGGACAGCGTGCGTTAATGCGGTGGCATTGCTGGAAAGATATTTACCTCCTAGCGAATTAGCACATAATGGGGATAACAGTAACTACATGCCGTACAGTAATGTACATCCAGAGTTtctgaaggagaaagaaaatatacccATGTTAATCCCAGAGGCTCCTATAGTAAATCCTAACGCGGCTCTAGGTACACCGCCAAGATTAAATTCCGATGGAGAAGCGGATAATGAGATAGAAGAACTTCTTGAAAATAGTGGCACGGATGAAGAGGCAACGATAATAGATGATTCAGATAGAAAATCTGACGAATATGAAATGGATATGGAAACGAATCCTAGCGATTTCTTAGAAATGACCCCAATGGTAACTGAAGATAATGAAGAAACAAGTTCCAAAAATATGCCTATGGTAACGCAAGAATCTACAGTATTCCAACATACATCGGAGCAACACgaagtgtatgtgtgttcgtTGTGTAACAAGGCATTCAGTTCTAAAGGACACTTGTCCCTTCATGCGAGAATTCATGTGGGTGCAGGCGATGTCATTGGTGAGAAAGTAATCACCGACGATCATACTTCCTATAAAAGGCCTTATCAATGTGATCTTTGCAACAAATCTTATTCAACGGCTAAACATCGATGGGGACATGTATCTACTACGCACAGAGGACATCCTGCCGTAACATGTGGGTATTGTTCACGCATTTATTCAACACGAACAAATCTTGAAGAACATATAAAATCGCGACATGCGGGATTACCGGCACCGTCCGAATTACCAAACCCCCTTTTCCGCTCGGAAACCAAATGTTACTGTAAAATGTGTTCCAAAAAATTTACGAGTATAGcagatttaaatattcatagtCGAATATGTATCGGACAACGAATAGAGCTGCAAGTGCAACAGGATATTAAGAGTGAATCACACAATAGTAAAAGTCTGATCGATACTTCGGATATATCCAGTATGGATACAGACGACGAACATAAGGGATTTAAAAACGCGGAAGCAAAATTAGCTAAAAATCCACAGCTTACGATACTGAAACAGGCGTTGACAAAGGGGAGTGGTTTAAAAAGAGATTTGGATGATAAAACAAGAGCAAATTGTAGTCCACAAAAACTAGTGAAAACAGATGGCTGTGAAATGCAGAAGAGGTGGTACTGCGAAATGTGTCCTCAAAGTTTTACGTCAGTGGAAAACCTTAAAGAACACGAGATAACACATGATGCTGACAAaccttatatatgtatattgtgtaAAAAGGACTTTACTTTAAAATCATCACTCAGCAGACATATCTTGGTATCGCATGGTGTAGATCCATGCCCTTTTATAGATAGTGATAAGTGTTTAAAAAGAGTAGTTCTTACGCAATCATGGGGTCAACAGATACCGATACCTATGTCCGATCAGAAAGACGCAAAGGAACCTTCGGAGTTTGCTCTGTCTCCAGAAACAAATGTggaaaatgaagatgaagacCAAGAGAGGAGTAATCACGAAAATATGGTAGAAATGGAGACAGTTTTTGTATGTGAAATATGTACAAGAGATTTTAATGATAGAGCATCATTGTGGTTGCATATACGTGCGACACATAAAGAATGTGCTGCTTTTGCTTGCGGAGTctgtttaaaaatatgttcTGACAATACACAACTCCTAAGTCACGTTAACATGTATCACGGAGGATCAAAGTTGCTAGTATCGGAACAAAGAAGGTATAGCTGTACAATATGTGGTAGACAACACGATtcacgaaagaaattaattgctCATGTATCGATACATAATGTAAATCCTGCTTATGACCCCGCAAATTTTGTACAGTTAAacagtaattattataacgaaaCGTTAAATGGTAACGAAGTAagtgaaaatattttggaGTTCGGAGATGGAGacgagggagaaaaaatagactgctatatttgttataaatcaTTTCCAAACGAGGATCATCTTATAAGACACCAGAGAAACGCTCATaagTTCGAACAAATGGCACCGATAGTAGATGCCATTGGTAATGGAAATCCAGGGAATATGAATGGTACTGGTAACAGAGCGcagtatcatttattttttgtctgtGAGCTTTGTGGTAGCTCACATCCCAGTAAATGGGAACGTTGGTTACATGTCAGTAGCACGCATAGTAACGAACCAAGTATAAAGTGCGAACGGGACGACTGCGGGAAAATATTTGCCACGAAGGCGTTGCGTAACGAACACGTACACCACCATCATTCGGTACAAGGTCCTTCGCCAAATACTTGTGAAGTTTGTGGTAAATTATGGGGTAGCCGAGTCGATTATTGGAAGCATGTGATGGGAGTACATTCCGATACAGTGCCACTTATATGTGGCGTTTGTCTCAAAGTATTTCCGAATGTATTGCAACTTAAAACACATGTGCAAACTAAACATTGGCCATTGACCAATGGCGATTTTAGTTGCGACATATGTGGTAGACCTTATTCGAATAAGTCTAAAATGTCAAGACATAGAAAAATTCATGGATTGGAAATCGATGGATATGATAATAACAGTATTAACGATGCCTTGAACGAATCGTCCAAGTACGAGCACAGTGTGCCGCCAGAAATGGATTTAACATGTGAATTGTGTGCCGATATGAAATTTCCAAATCTGGAAAGTTTATGCAGTCATAGACGTATTGTGCACCGTCTATTTCCGTGTGATCTTTGTAACAAGTGTTACGGCAGAACGTCTCATTTATGGAAACATGTAAATCGGGTACACAAAGGTCACGTAGACATAACGTGTCCTTACTGTTTGAAAACGAGTGCGTCTAAAGACCATTTAGCGGCACACATAGCCAAAATTCATAGGTACGAGTTAGAAGTTagaaaggataataaaaattcagtAAATTTCAAATCTTCGAACGTAGAAGACGGAGTTTTGCATTATtgtgaaaaatgtaataaaggATTTCATAAACGGTACTTACTTAGACGTCACATGAAAGGTTGTCAGAATTATAGAAAAGATCCAGGCGCGTTGTTGACCCGTTGTCGCGCCTgtgaaagaatatttaaagatCGCGCGAGTTTACAAAAGCACATAGAAAATCATCATAGTACGTACACTTGCCATTTATGTAACGAAACTATTACCTCTAAATTGGGTATTATGACACATAATCGGGTTAAGCATATGGATCATCCAGATCTTACGTGCGACTATATTagttgtaaaaaattattcagaaCGAAGGAAGACTTGGAGGCTCATAGGAAGGATCATAAATATCACATAAGTCCGAACGTTTGTGACTTCTGCGGTGATACCGTGgagaataaattgaaattaaaaatgcaCGTATTGTCTTTGCACCGAAACGAAATCGGTGTGTCTTGCGGAGTTTGTTTGATACCTATGAAAGATCCAAAGGATTTGAAGAAACACGTCGAGGACGTGCACGAAAGTGTTTTATCTAAACCGAACACGTGTCAGGTATGTGGGAAACAGTACGCGTCTAAATGGAAAGCGTTCGATCACACGAAGAAATGTCATGGGAAGGTGTTTAGAACGTGCAAGCAATGTTTGGCTGTTTTTACGAACGATTCGGATATCAGAGATCATTATGAGCACGTTCATAACATTTCTAAAGATCAATTAGCTGCGTTCGAGTATCGCATGGACATCGGATCAAAGGTAGACGAGTACGACGGAGTACCAGCGGATATAGTCGTCAAGGAAGAACCGGACGATTTGGATTTCGACGAGGACTTGTGCGAGGACGATTTGAACAATTCCAAACGTAGGAGATCGTTAACCGACACCTACGATTGCGAGATGTGTCCGGAAATTTTCTTGAATTGTCACACATTGGCGAAACATTATCAAAATGTTCACAATACCGATCCAATTCGTATGTTCAAAAAGATAAAGCCGGACAACAGCGACAGTAGCAAAAGGAAGATgagaaatcgaaagaatttcGAGTGCAAAAATTGTCAAAAACAATTCTGCACGAAAACGTTGTTTTGGAATCACATCAACGTATGCACGAGGCGTAACGCGTTCAACAGATTGGACATGCAAAGTATCATGCCAACTTCGATTTTGGAGACGCATTTgaagaataataatcaaataaagaaagaagaaacttccTCGTTTATGAACGAATCGAATTTAAACATTCcagattttaatttatttgaagaTATTAATCTACAGTTATCAGGGCAGAAGCCAGTACCGAATCTTATGCCATTGTCGCATATGAAACCTCCTACTGCGGTGAAATGCTCTAGGAAAGATTCTCGAAAGGTATACGACGAATCAACGAATACCGAATGCACGTGCGAAGTTTGTGGTAAACAATGGCCAGCGAAAAAGCATCTGTGGCAGCATCTCATTCGTTTTCACAGAGCGGAGGCAGCGGTTACTTGTGGGGTTTGTTTGAAATTATGTAAATCTTATCAGGATCTGTCCGATCATTTGAAGGCCACACATGCCGCGATATTATCCTGCGAGGGAAATAATTTCACGTGTAAAACGTGCGGACGTTATCACAACGCAAGAAGCAAATTATTGTTACATATGAGCATTCACATCAATTACGTTGGAAACTTTTGGTGTCAGAAGTGTCAGTTAAATTTCGAAAGCGAGAGTAAATTTTCTGAACATATATTGGAATGCAACAAGAAGATAGAGTCTGGTCGTAGTAACATAgaagataatataaagaatgaaaacgaCGAGAAGGGAAGTTTGATAGGGGATGAGACGTCGGTCGTCGAGGAGGTCGAAGAAGTCGAAGATTTCGAGTCGGAACCGGAGGAGGATGGCGTAACACAGGAGGAGAGTAACAGCGAGAATTCAGAAAATTCTGAGGATTCGGATAGTGCTAGTAACACCAGTACGAGCGACGAGGAGGAACCGGAAGAGGAAAATGATTCTGAAGCTGAGTCTAGATCCAACAGTAGGGCGATAATAGGTGAGGTATCGTGTAATACCGAAAGCGACGATACCGATTCAGAAAATTCGGAGAATTCCGCTgagatcgataataaaaatttaaacgaGATGAATTGTTTTATGATGTGCACAGAGGAGGATAAGGATAGGAATATCGatgggaaagaaaatttggaagagcgattaataatgaatacgGATGCGATAGGAGAAACTAAAGATATTAATCAAGAGGGACAACGGGAAGAATTGGATTTGAAGGAATCGGTTAATGGTACGAAGTTGAACAATTTTCACGTTAAGGAAACTGtcgaggaaggaagaagcgaTTTGGATTTTACGGACGACGATGGTCCACCTGTTTTGAGTCCAATTATGCCTTTGTTAGAACAGGAGCAATCGGAACGACACAATAATCCTATGGACGATATGAGACACAAGCTTAGTCCTATGGTACCGTTGACGattaacgatgaaaaagaattagaaatgtGTGAACTGTCTGAAAATGGTAACGACGTTGAAAGAGCTACGACTTCGTCCATGTCGAATCCcattaattattacgaaaataCGGATAACGAAAAAGACATGAACGCTAATGCGTCTACGCATAATTTAGAGTACGGGTGTGaggattttgaaaatattgacAACGAGGAGGAAGATAGTATATCGGTCAACGAGGATGGACAAATGGAAATAGACGAACGGAACGTAGATTGTAATTCCGTAAatagatatgaaaaattagaaattaacgaGTGTATCAACGATTCCGAGGTAGATTCTTACGAGGAAAATTTAGACGAGGAGATTAAATTTGACAATGAGACCAGAGATAACGATGTACAAATTCATAATTTGAGTGGTGCTGTATTGATGGTAGCTAACGATTCGGACGGTAATCAGATTTTAATTCAACAAAATGTATTAACAATAGGAAATGAGGATTCTAATACAGGTGCGacagaatatatttatcacgAAACGAATGAGTACGAGATAGAAGAGTACGGTATAGCACAGCATGAAACAAATTCTACGATACAGTCTGATGATATTCAAGAGATGGCGTATGTTCAAGATATATCAGAAAATGAGGATAGCATCGAAGAGGTAGTAGAAATACATGATATAGAGGAACAAAGTATGAGTGCCAAAAGCAAACAATCTAACTTATAA
Protein Sequence
MTTTTTTTTTTTTTTTTTTTTTTTMESRQRYHELCRLCASYDAVKMDIFGQEGKNRQLVDKIQTCLPFKITENDRLPKCLCYRCMYNLENFYDFRTACVNAVALLERYLPPSELAHNGDNSNYMPYSNVHPEFLKEKENIPMLIPEAPIVNPNAALGTPPRLNSDGEADNEIEELLENSGTDEEATIIDDSDRKSDEYEMDMETNPSDFLEMTPMVTEDNEETSSKNMPMVTQESTVFQHTSEQHEVYVCSLCNKAFSSKGHLSLHARIHVGAGDVIGEKVITDDHTSYKRPYQCDLCNKSYSTAKHRWGHVSTTHRGHPAVTCGYCSRIYSTRTNLEEHIKSRHAGLPAPSELPNPLFRSETKCYCKMCSKKFTSIADLNIHSRICIGQRIELQVQQDIKSESHNSKSLIDTSDISSMDTDDEHKGFKNAEAKLAKNPQLTILKQALTKGSGLKRDLDDKTRANCSPQKLVKTDGCEMQKRWYCEMCPQSFTSVENLKEHEITHDADKPYICILCKKDFTLKSSLSRHILVSHGVDPCPFIDSDKCLKRVVLTQSWGQQIPIPMSDQKDAKEPSEFALSPETNVENEDEDQERSNHENMVEMETVFVCEICTRDFNDRASLWLHIRATHKECAAFACGVCLKICSDNTQLLSHVNMYHGGSKLLVSEQRRYSCTICGRQHDSRKKLIAHVSIHNVNPAYDPANFVQLNSNYYNETLNGNEVSENILEFGDGDEGEKIDCYICYKSFPNEDHLIRHQRNAHKFEQMAPIVDAIGNGNPGNMNGTGNRAQYHLFFVCELCGSSHPSKWERWLHVSSTHSNEPSIKCERDDCGKIFATKALRNEHVHHHHSVQGPSPNTCEVCGKLWGSRVDYWKHVMGVHSDTVPLICGVCLKVFPNVLQLKTHVQTKHWPLTNGDFSCDICGRPYSNKSKMSRHRKIHGLEIDGYDNNSINDALNESSKYEHSVPPEMDLTCELCADMKFPNLESLCSHRRIVHRLFPCDLCNKCYGRTSHLWKHVNRVHKGHVDITCPYCLKTSASKDHLAAHIAKIHRYELEVRKDNKNSVNFKSSNVEDGVLHYCEKCNKGFHKRYLLRRHMKGCQNYRKDPGALLTRCRACERIFKDRASLQKHIENHHSTYTCHLCNETITSKLGIMTHNRVKHMDHPDLTCDYISCKKLFRTKEDLEAHRKDHKYHISPNVCDFCGDTVENKLKLKMHVLSLHRNEIGVSCGVCLIPMKDPKDLKKHVEDVHESVLSKPNTCQVCGKQYASKWKAFDHTKKCHGKVFRTCKQCLAVFTNDSDIRDHYEHVHNISKDQLAAFEYRMDIGSKVDEYDGVPADIVVKEEPDDLDFDEDLCEDDLNNSKRRRSLTDTYDCEMCPEIFLNCHTLAKHYQNVHNTDPIRMFKKIKPDNSDSSKRKMRNRKNFECKNCQKQFCTKTLFWNHINVCTRRNAFNRLDMQSIMPTSILETHLKNNNQIKKEETSSFMNESNLNIPDFNLFEDINLQLSGQKPVPNLMPLSHMKPPTAVKCSRKDSRKVYDESTNTECTCEVCGKQWPAKKHLWQHLIRFHRAEAAVTCGVCLKLCKSYQDLSDHLKATHAAILSCEGNNFTCKTCGRYHNARSKLLLHMSIHINYVGNFWCQKCQLNFESESKFSEHILECNKKIESGRSNIEDNIKNENDEKGSLIGDETSVVEEVEEVEDFESEPEEDGVTQEESNSENSENSEDSDSASNTSTSDEEEPEEENDSEAESRSNSRAIIGEVSCNTESDDTDSENSENSAEIDNKNLNEMNCFMMCTEEDKDRNIDGKENLEERLIMNTDAIGETKDINQEGQREELDLKESVNGTKLNNFHVKETVEEGRSDLDFTDDDGPPVLSPIMPLLEQEQSERHNNPMDDMRHKLSPMVPLTINDEKELEMCELSENGNDVERATTSSMSNPINYYENTDNEKDMNANASTHNLEYGCEDFENIDNEEEDSISVNEDGQMEIDERNVDCNSVNRYEKLEINECINDSEVDSYEENLDEEIKFDNETRDNDVQIHNLSGAVLMVANDSDGNQILIQQNVLTIGNEDSNTGATEYIYHETNEYEIEEYGIAQHETNSTIQSDDIQEMAYVQDISENEDSIEEVVEIHDIEEQSMSAKSKQSNL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
iTF_01512963;
80% Identity
-