Vger001932.1
Basic Information
- Insect
- Vespula germanica
- Gene Symbol
- lz
- Assembly
- GCA_905340365.1
- Location
- HG996529.1:6283338-6296658[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.6e-73 8.7e-70 232.0 0.0 3 129 73 199 71 199 0.98
Sequence Information
- Coding Sequence
- ATGCATCTACCGGTGGGTTCCGTGGGCTGCGGGGAGAATTACGGCACCGTCGGATCTCAGGAAGGCGCCGGCCCGTGCGGTCCCTCCCTGGCACCCCTCCAAGGGGTCAACACCAGGTACCACCAGGGTGAAGACGGCGAAAACGGCGGTGGTGCCGGCGAAATGAGCGAAGGTGCCGCCGTCGGCGAACTCTGGTGGACCGAGAGACTCGTCGGTGAGGCACAGGCTGAACATCCCGGCGAACTCGTTAGAACAGGTTCGCCGTATTTCCTCTGCAGTCAATTGCCGACTCATTGGAGATCCAACAAGACCCTACCAGTAGCTTTTAAAGTTGTAGCCCTCGGCGAGGTCGGCGATGGAACCCTCGTTACTGTTCGCGCTGGTAACGATGAAAACTGTTGCGCGGAACTACGTAACTCGACTGCACTTATGAAGAATCAAGTCGCGAAATTCAATGATCTTAGGTTCGTCGGTAGAAGTGGAAGAGGAAAGAGCTTTAGCATCACGATAACCGTTTCGACCAGTCCACCTCAGGTAGCAACCTATACCAGAGCGATCAAGGTGACCGTCGATGGACCGAGAGAGCCACGTTCGAAAACGAGacaacaacatcaacaatTTCGAGCTCTTGGTTTGGGTCAGAGACCATTCTTGGATGCCCCAAGCTCGTTCACCTCCCACCTACGAGAACTGGAGTCGTACAGGAGGAATAAGCATCACCATCATCACAGCAGTCACTTACACGGACAGCAGACTGGCAGCAACGTCACCGCGAATTCGGTTAGCGGTGCCTGTTCCAACCCCAACAACACCGACCCAACCGCATCGCCCGCTTCCAGTACACACCTCGGAGCTACCGGAGGAGGTTCCTCTAGTACTGCTCATCAGGATTGCTACAAGCATAGTCCTCAACACGGTGATGGATCATTGGACAGCTCGATATCACGAGTTCGTAATATAATTTGGGATGCAAAAAGGCAGCTGGATCAGGCCAACTCAGGCACTTTATTTTCTACGTTGCTCGTCTCGGATCAGCGGTCTCGACCTGATCAAAGTTAA
- Protein Sequence
- MHLPVGSVGCGENYGTVGSQEGAGPCGPSLAPLQGVNTRYHQGEDGENGGGAGEMSEGAAVGELWWTERLVGEAQAEHPGELVRTGSPYFLCSQLPTHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGKSFSITITVSTSPPQVATYTRAIKVTVDGPREPRSKTRQQHQQFRALGLGQRPFLDAPSSFTSHLRELESYRRNKHHHHHSSHLHGQQTGSNVTANSVSGACSNPNNTDPTASPASSTHLGATGGGSSSTAHQDCYKHSPQHGDGSLDSSISRVRNIIWDAKRQLDQANSGTLFSTLLVSDQRSRPDQS*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01233423; iTF_01497973; iTF_01513943; iTF_01423418; iTF_01354397; iTF_01422013; iTF_00884831; iTF_01267325; iTF_01269575; iTF_01268792; iTF_01089773; iTF_01254574; iTF_00867170; iTF_00729069; iTF_00306033; iTF_01255314; iTF_01473690;
- 90% Identity
- iTF_01267325;
- 80% Identity
- -