Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0003 0.023 15.8 1.8 2 23 178 199 177 199 0.97

2 6 0.0023 0.18 13.0 2.8 2 19 205 222 204 227 0.89

3 6 0.0031 0.24 12.6 0.2 2 23 234 255 233 255 0.97

4 6 0.0022 0.17 13.0 0.6 1 23 261 283 261 283 0.97

5 6 0.001 0.078 14.1 0.2 2 23 290 311 289 311 0.97

6 6 0.00011 0.0088 17.1 1.5 1 23 318 341 318 341 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0003	0.023	15.8	1.8	2	23	178	199	177	199	0.97
2	6	0.0023	0.18	13.0	2.8	2	19	205	222	204	227	0.89
3	6	0.0031	0.24	12.6	0.2	2	23	234	255	233	255	0.97
4	6	0.0022	0.17	13.0	0.6	1	23	261	283	261	283	0.97
5	6	0.001	0.078	14.1	0.2	2	23	290	311	289	311	0.97
6	6	0.00011	0.0088	17.1	1.5	1	23	318	341	318	341	0.97

Coding Sequence: ATGGAGCTTTGGCTATGTTGTCGGACTTGCTGCGGTGTTCTAGAGTTAAATCCGATATTTCGTTTGGAGGAGCATCATGAAAAGTACTCTTTAGTGCTCTTAGAAACTACAGGAGTTAAGATTGACTTCAACGACTCTCTTCCTCAAGTTATATGCACAACCTGTCTTAACTTTATAAATGAATCATACAAGTTTCGGAAGCAATGCCAGCAAGCACAATCATCACTAACAAAACATTCCAATGATGACAATAAATATCAATTAGACTGTGAACTAGAAGACAAATTACATGCAATTGATATAGCGGATCTAGTCCAAGATATTGACAACACAAATATTGAAGAAAATCTAAATTCACatgattatgataatacttTAAATGACACTAATGATGAGTTAGAAAAGAGTGATCACGAAATTAAAGATAGTAAACCGAAAGTGAAGAGAAAACCAATAAAGTCTAAAGAAAAGCGAGCTAGAACAAGAAAGCCTGATAAGAATAATGAAGGACAACAAGAGAAAGAAGAAATAGAGTGTGAATATTGCCATAAGATTTTAACGTCAAAATTGTCTTTGCGGAACCATTATAAGATACATACCGGCTTTGACGTAGTTTGTGAGcACTGTGGTAAGAAGTTTATAACCCGTCGCTTGCTGCTCATGCATTGTAAGGCGAAACATGGATACGAGAAAACAGACAAATGCTCCTACTGTGACTACCGGGCGTCCAACGCTGAGCAGGttaagATACACGAGCGCCTCCACACGGGTGAGAAGCCCTACTCTTGCGGGTCCTGTGACGCCGCTTTCCACCGAAAAAGCAGCTACCTACAGCACGTCGCTATACATTTACCAGATAAAACTGTGCAGTGTCCGGAATGCCCGGGTCGCTTCAAATCGGTGACACTGATGCGTATCCACATGTCGCGACATCGCGCGACCCGCTACTCGTACCGCTGCGCGCTCTGCGACCGCGACTTCGCGCGGCGCCGCAACGTCGCGCGACATCTGTGCAGGATACACGCCGTCAGCCCGCGACCGGATCACATACAGAGGAAGGCGGTTTGA
Protein Sequence: MELWLCCRTCCGVLELNPIFRLEEHHEKYSLVLLETTGVKIDFNDSLPQVICTTCLNFINESYKFRKQCQQAQSSLTKHSNDDNKYQLDCELEDKLHAIDIADLVQDIDNTNIEENLNSHDYDNTLNDTNDELEKSDHEIKDSKPKVKRKPIKSKEKRARTRKPDKNNEGQQEKEEIECEYCHKILTSKLSLRNHYKIHTGFDVVCEHCGKKFITRRLLLMHCKAKHGYEKTDKCSYCDYRASNAEQVKIHERLHTGEKPYSCGSCDAAFHRKSSYLQHVAIHLPDKTVQCPECPGRFKSVTLMRIHMSRHRATRYSYRCALCDRDFARRRNVARHLCRIHAVSPRPDHIQRKAV

Sequence clustering based on sequence similarity using MMseqs2