Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 1.7e-05 0.0013 19.7 6.9 1 23 193 215 193 215 0.98

2 5 4.9e-06 0.00038 21.4 0.4 2 23 228 249 228 249 0.97

3 5 1.5e-05 0.0012 19.8 2.9 2 23 258 279 258 279 0.98

4 5 3.6e-05 0.0028 18.7 2.1 1 23 285 307 285 307 0.98

5 5 0.0017 0.13 13.4 0.4 1 17 313 329 313 330 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	1.7e-05	0.0013	19.7	6.9	1	23	193	215	193	215	0.98
2	5	4.9e-06	0.00038	21.4	0.4	2	23	228	249	228	249	0.97
3	5	1.5e-05	0.0012	19.8	2.9	2	23	258	279	258	279	0.98
4	5	3.6e-05	0.0028	18.7	2.1	1	23	285	307	285	307	0.98
5	5	0.0017	0.13	13.4	0.4	1	17	313	329	313	330	0.94

Coding Sequence: ATGGCTGGAGTTACCGTGGTGAATCTAAAATTTCGGACTTTGCAGTTCGACAAGATATGTCGAGCATGTTTGGAAGTGAAAAGGGACATGAGACCATTATTCGAACAGCTGACTGCGACGATGCTGATGGGCATTTCGAAAGTAGAGGTGTCTCTAGGCGACGGGCTGCCTTCGCAGCTGTGTCTTCAGTGCGTGCATCAGATCTCGCGATGTAATGCCTTCAAAGAGCAGATCGAAAGAAACGATCTGAGGCTCAAGGAACATGCCAAGTTCATAGCTGATGAGGCGGCTAAGCGGGAGTGCGAGGAGAAGGAAAAGGCTCTACTGAACATGTCGTGTCCCGACAACTACATGCAATACATGgaagtacctataataaataacaCCAATCAGATGCTCGATGGATTTTTCGCGCCCACATCTGACCAATCGGAAACCCAGATTGAACAAGTGAAGGCAGAAGAAAAGCCACTTGAAACTGCCACCACAGCTGCGAAGCCAGAAGAAACCTCCGACGATGAGAACTACATGCAGCTGGTGGTGTTCCAAGCCACGTCGAGCGTGTCCCCGGGGAGGCACGTGTGCAACCTCTGCCATAAGGAGTTCAAACATGCGAGGTGGCTGAAGCAGCATATGCGATCGCACACTAACTGGCTCAAGGCGAATTGCAAGAAGCCTCCTAGCTGTAGCATATGCGCGAAAACATTCAAGGGCCCAGGAATGTTGAAAATGCACATGCGCACGCACGAGCTGCGCCCCCCGAAGCAGCCGACGTGCTCCGTCTGCCAGCGCACCTTCTCCTCCAAGACGCTGCTGTACCGACACCGCCAGACCCACTTCGAACAGAAGACGCACCAGTGCACGGTCTGCGACAAGCGTTTCTTCAGCGGGTACGCTCTGCGCTCGCACATGGCGCGCCACCGCGGCGAGCGCCCATACATCTGTTCCAATTGCAACAAGAGCTTCTATAATCCTACTGATTtgaaggtatatttatttttgtatttgaagcaagcctcagctcagttggtagtagctctgccttccgcgctgcaggcggtttga
Protein Sequence: MAGVTVVNLKFRTLQFDKICRACLEVKRDMRPLFEQLTATMLMGISKVEVSLGDGLPSQLCLQCVHQISRCNAFKEQIERNDLRLKEHAKFIADEAAKRECEEKEKALLNMSCPDNYMQYMEVPIINNTNQMLDGFFAPTSDQSETQIEQVKAEEKPLETATTAAKPEETSDDENYMQLVVFQATSSVSPGRHVCNLCHKEFKHARWLKQHMRSHTNWLKANCKKPPSCSICAKTFKGPGMLKMHMRTHELRPPKQPTCSVCQRTFSSKTLLYRHRQTHFEQKTHQCTVCDKRFFSGYALRSHMARHRGERPYICSNCNKSFYNPTDLKVYLFLYLKQASAQLVVALPSALQAV

Sequence clustering based on sequence similarity using MMseqs2