Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00076 0.059 14.5 0.3 1 23 13 35 13 35 0.96

2 6 0.00045 0.035 15.2 0.3 2 23 42 63 41 63 0.95

3 6 3.4e-06 0.00026 21.9 2.2 1 23 69 91 69 91 0.98

4 6 3.5e-05 0.0027 18.7 2.7 1 23 97 119 97 119 0.96

5 6 4.3e-05 0.0033 18.4 1.2 1 23 125 148 125 148 0.96

6 6 6.1e-05 0.0047 17.9 1.1 1 23 154 177 154 177 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00076	0.059	14.5	0.3	1	23	13	35	13	35	0.96
2	6	0.00045	0.035	15.2	0.3	2	23	42	63	41	63	0.95
3	6	3.4e-06	0.00026	21.9	2.2	1	23	69	91	69	91	0.98
4	6	3.5e-05	0.0027	18.7	2.7	1	23	97	119	97	119	0.96
5	6	4.3e-05	0.0033	18.4	1.2	1	23	125	148	125	148	0.96
6	6	6.1e-05	0.0047	17.9	1.1	1	23	154	177	154	177	0.92

Coding Sequence: ATGGAAAACAAGCAAACAGAGTCGCCAGAAGAGATTTTCAAATGTAAGAAATGTGTTGAAGAATTCATGACCATAGAGGCTTTGAATCAACATATGGTTTTACATAAGGACAAAAAGATTTGGATCTGTGATACATGTGGGAGAGTGTTCCTGCGCCGGGACTACCTCTACAAGCACAAGTTAATACATGAAGGAAAAAAACTGCATGTCTGTCCATACTGCAAATTCCGCACAATACAGAAATCATCACTAAATGTACACATCAGGACGCACACAGGGGAGCGCCCTCACGCGTGCGCGCTGTGTCCCCAGCGATGCGTCAACAGCTCTAACCTGAGGGAGCATATGAAACGGCATCTGGGTCTCAAGCGTTTCCATTGCCAGCTTTGCGATAAGAAGTTTGGCTACAAAGCAAGTCTCGAGGAACATATCTCATCAATCCATGAACGGTCAGAAGTGCATACTTGCACCGAATGTGGCGCCACCTACACCCGGTTTAGAGGTTTGCAGCGACATCTAGCAGCGAAACACGGAAAACAGGTTAAGAAAATTAACATGGTTGCCAATCCAGTCAAAGAGAATAATTCAATGGCTGAGAATATAGATGGCGTTGTTGTCAGTATGTCCAGTTAA
Protein Sequence: MENKQTESPEEIFKCKKCVEEFMTIEALNQHMVLHKDKKIWICDTCGRVFLRRDYLYKHKLIHEGKKLHVCPYCKFRTIQKSSLNVHIRTHTGERPHACALCPQRCVNSSNLREHMKRHLGLKRFHCQLCDKKFGYKASLEEHISSIHERSEVHTCTECGATYTRFRGLQRHLAAKHGKQVKKINMVANPVKENNSMAENIDGVVVSMSS

Sequence clustering based on sequence similarity using MMseqs2