Basic Information

Gene Symbol
-
Assembly
GCA_037043105.1
Location
CM073304.1:1871733-1873600[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.00095 0.069 14.1 0.4 1 23 88 111 88 111 0.93
2 9 3.3 2.4e+02 2.9 0.0 2 23 136 158 135 158 0.88
3 9 0.00012 0.0085 16.9 2.2 2 23 181 202 180 202 0.97
4 9 0.00017 0.012 16.4 0.0 1 23 206 228 206 228 0.98
5 9 0.00076 0.056 14.4 1.7 1 23 233 256 233 256 0.97
6 9 1.4 1.1e+02 4.1 1.7 2 23 264 286 264 286 0.92
7 9 1.5e-06 0.00011 22.9 2.0 2 23 294 316 293 316 0.96
8 9 4.1e-07 3e-05 24.7 1.4 1 23 322 344 322 344 0.98
9 9 2.4e-07 1.8e-05 25.4 3.9 1 23 350 372 350 372 0.98

Sequence Information

Coding Sequence
atgaaaatttccAAGTGTCAGCATTCTAGATCCGGTGATGAACAAATAATCATCGTATCTGGAGAAAAGGCCGAAGAGCTCCTACACAAATTACAAGTCAAGTCAAGCGTAAATAGCACAGCGCGTGGCCGTAATAAGAAAactcctaaaaataaaatagatgacAAATGTATGCTAGAAGTTGAGAAACATCGGAGCAATATGACGGAAATATTGTTGAATTCAAACGCTACGCCGATACGGTTTCGTGGTGATATAGGATACGCTTGTTGCTTTTGTACCGAACAGTTTCCTGATCCTGCGGATTTAAAAAGGCACACAATTGAAGGACATGATGCGAAGAGTATTAAACAAGTTGTCCAAGAAATGCGCGTGTACACAGTCAAATTAGACATAACGGAATTGAAGTGTAACCTGTGTCAAAACGATCTACCAtcaatagataaattaatagaCCACTTAATAGATGAACATCAGCATGTTATCTACACGGATATCAAAAATCACATGGTACCATTTAAGTTTCAAGGCGAAGAGCTGAAGTGTGCGTTGTGTTCGACGAAATTCACGAAATTCAGAAATTTGACGGAACATATGAATACACATTTTCGTAATTACGTTTGTGACGTCTGCGGTGCTGGATTCGTCAACCGTGACATACTAAGGAGTCACTTGAGAATACACAAAACAGGTTTGTTTTCGTGCGATTTCTGTTCGAAGACGTTTAACACGAGAGTTAAAAAACAGtcacatataaatattgtacacaGGCGGCTTTACATGACGAGAAAATGCGGGTACTGTAACGAACTGTTCGACGATTACCACAAGAAAAGTGATCACCTGGCTAAATATCATGGAGTTACACCGACAGTGTTGAAATGTGATTCCTGCGATAAGACGTTCACAAATCAGCAAGGATTGAGACGGCACACCAGACGGGACCATTTGATGGAGAGGAACTTTGAGTGCAAAGTTTGTGGCATGAAGTTCTTCAGTAGCGAAAATTTGAACAAGCACATGTTGAAACATACAGGCGAGCGACATTTCCACTGTAGCTTATGTGGAAAATCGTTCGCTCGTAAATTCACCCTGAAACAACATATGCGAGTACACACGAAGGAACGAAGGAGCCCTGTTCGAACATCCGCTAAATATTTGGTCATTGATGATAATATTGAATCGGACGCTGATGAAACTATAGCTTAA
Protein Sequence
MKISKCQHSRSGDEQIIIVSGEKAEELLHKLQVKSSVNSTARGRNKKTPKNKIDDKCMLEVEKHRSNMTEILLNSNATPIRFRGDIGYACCFCTEQFPDPADLKRHTIEGHDAKSIKQVVQEMRVYTVKLDITELKCNLCQNDLPSIDKLIDHLIDEHQHVIYTDIKNHMVPFKFQGEELKCALCSTKFTKFRNLTEHMNTHFRNYVCDVCGAGFVNRDILRSHLRIHKTGLFSCDFCSKTFNTRVKKQSHINIVHRRLYMTRKCGYCNELFDDYHKKSDHLAKYHGVTPTVLKCDSCDKTFTNQQGLRRHTRRDHLMERNFECKVCGMKFFSSENLNKHMLKHTGERHFHCSLCGKSFARKFTLKQHMRVHTKERRSPVRTSAKYLVIDDNIESDADETIA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01507488;
90% Identity
iTF_01506604;
80% Identity
-