Basic Information

Insect: Vanessa tameamea
Gene Symbol: NFIA
Assembly: GCA_037043105.1
Location: CM073301.1:7618997-7631037[-]

Transcription Factor Domain

TF Family: CTF_NFI
Domain: CTF/NFI and MH1 domain
PFAM: PF00859
TF Group: Unclassified Structure
Description: Nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF) [2, 1, 5] (also known as TGGCA-binding proteins) are a family of vertebrate nuclear proteins which recognise and bind, as dimers, the palindromic DNA sequence 5'-TGGCANNNTGCCA-3'. This family was first described for its role in stimulating the initiation of adenovirus DNA replication [6]. In vertebrates there are four members NFIA, NFIB, NFIC, and NFIX and an orthologue from Caenorhabditis elegans has been described, called Nuclear factor I family protein (NFI-I) [4]. The CTF/NF-I proteins are individually capable of activating transcription and DNA replication, thus they function by regulating cell proliferation and differentiation. They are involved in normal development and have been associated with developmental abnormalities and cancer in humans [5]. In a given species, there are a large number of different CTF/NF-I proteins, generated both by alternative splicing and by the occurrence of four different genes. CTF/NF-1 proteins contain 400 to 600 amino acids. The N-terminal 200 amino-acid sequence, almost perfectly conserved in all species and genes sequenced, mediates site-specific DNA recognition, protein dimerisation and Adenovirus DNA replication. The C-terminal 100 amino acids contain the transcriptional activation domain. This activation domain is the target of gene expression regulatory pathways elicited by growth factors and it interacts with basal transcription factors and with histone H3 [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.0018 22 5.2 0.0 4 32 187 215 184 237 0.73

2 3 0.14 1.7e+03 -1.0 3.0 205 261 213 272 208 294 0.68

3 3 2.6e-10 3.2e-06 27.7 8.4 179 271 305 401 254 412 0.75

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.0018	22	5.2	0.0	4	32	187	215	184	237	0.73
2	3	0.14	1.7e+03	-1.0	3.0	205	261	213	272	208	294	0.68
3	3	2.6e-10	3.2e-06	27.7	8.4	179	271	305	401	254	412	0.75

Sequence Information

Coding Sequence: ATGAGTCTTGAGGAGGAGCGACACACAAAGTATGAACTACAGAATGAAAAAGCAGAAGTAAAACAGAAATGGGCTTCGCGTCTACTCGGGAAGCTGAGGAAAGATATAACGCAAGACTGTCGAGAGGATTTCGTCCTCAGTATCACGGGCAAGCGGCCGGCCGTGTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGAGACGGATAGACTGCTTGAGGCAAGCTGATAAGGTGTGGCGCTTAGACCTGGTAATGGTGATATTGTTCAAAGCGATACCGCTAGAGAGTACAGACGGGGAACGCTTAGAGAAGCACCCAGAATGTACGCAGCCGGGGCTCTGCGTCAACCCTTACCACATCAACGTGTCTGTGCGCGAACTAGACTTGTACCTCGCGAACTTCATCAACAGCTATGGTAATGGGAGCGACGGTCTACCAGATATACTAAGCGGATCTCTCTCTCCACATCCCACTAGGGACAAAGAGAATGAACACGAGGCTAAGAACAAAGGCTATACCCATAATCCATACAACGGTGTTATTTGCAACGATATCATTTTAGCGACCGGTGTCTTCTCTTCGAAGGAACTATGGAAGTTATCTAAAGCGTCTATCCTCCAAGAAACAGGATCCGAATCACCGGGGGGCTCCGGGGGCATCAAACTGGAGTCCACGTACTATGGGTACAACagccccgcgccgcccgccttCGAGCCGCCGCCCGAGCGCGCCACGCCCTCCGCCATGCTCGTCGGCCAGTGCTTCAGTATTCCCCATAGTTCAGCGGGTCTGAGCGCAGCACAATCGCCCCTAGTGCCTTCTAACACCATCTTCTACCAGCACGCCCCACCTCCCACGGATACACATCCAACGGCGTCAGAAGCGCTAACGAACCAGCACGGCGGGAAGTACGACGGCGCGCCGCAGGACTCGCTCGGGGACTTCGTCACTTTCGTGTGCCAGGAGCCGCCCTCGGATGTGCAGCAGTTACAGgttCACAGTTTATCGAGAAGCCCCAAGCCTTACTTCAGCAGTTCGATGTTACCCCCACCGCCTCTGCCCCCCATGGCGAGGCCGGTCACAATTATCAGATCTACGgCGAGCGAGGTGGGCGTGGGCGTGGGCGGCGTGGGCGTGGGCGTGGGCGGCGGCTCGCCGGCGTCCCCCGAGGTGCGCTCGCCGCCCGCGTCGCCGCGCCGGCGCTCGCCGCACTACCGCGACTGCCACCCGCCCATCTCCCACTTCAACCACTACCACGCGCAGCCGCAACAGGTGTTCGGCtacggcgcggcgggcggcggctcCCCGCCGGGCGGGCTCGGCCTGTacgcgccgcgcgcgccgccccgCGCGCCGCACAGGTGGAACGCTCCATTCCCAACATTAGAGGAAGAGTTTAATATAATGACAGCACCAACGGGGCCTGACCACGTCGTGCTCTTAGACGATGAACGCTTCTTCCAATCCAACGTGATCACCTCGGACGCGACGGCCATGGACACGGGCGCCAGCGTGGGGCAGGCCGTGGGCGTGGACGCCGACGAGCTGGCGCCCGACAAGCCGGCGCCCGACCTGCGCTCGCCGTGA
Protein Sequence: MSLEEERHTKYELQNEKAEVKQKWASRLLGKLRKDITQDCREDFVLSITGKRPAVCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKAIPLESTDGERLEKHPECTQPGLCVNPYHINVSVRELDLYLANFINSYGNGSDGLPDILSGSLSPHPTRDKENEHEAKNKGYTHNPYNGVICNDIILATGVFSSKELWKLSKASILQETGSESPGGSGGIKLESTYYGYNSPAPPAFEPPPERATPSAMLVGQCFSIPHSSAGLSAAQSPLVPSNTIFYQHAPPPTDTHPTASEALTNQHGGKYDGAPQDSLGDFVTFVCQEPPSDVQQLQVHSLSRSPKPYFSSSMLPPPPLPPMARPVTIIRSTASEVGVGVGGVGVGVGGGSPASPEVRSPPASPRRRSPHYRDCHPPISHFNHYHAQPQQVFGYGAAGGGSPPGGLGLYAPRAPPRAPHRWNAPFPTLEEEFNIMTAPTGPDHVVLLDDERFFQSNVITSDATAMDTGASVGQAVGVDADELAPDKPAPDLRSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00796541;
90% Identity: iTF_00824756;
80% Identity: iTF_01508090;