Basic Information

Gene Symbol
-
Assembly
GCA_905147765.1
Location
LR990549.1:6163684-6173700[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 4 3.1e+02 2.5 0.1 3 17 60 74 58 75 0.87
2 13 0.0028 0.21 12.4 0.1 2 19 187 204 186 205 0.95
3 13 0.0045 0.35 11.7 1.1 1 23 248 270 248 270 0.93
4 13 0.0023 0.18 12.6 0.0 3 23 347 368 346 368 0.96
5 13 0.0024 0.18 12.6 0.2 2 20 374 392 373 394 0.92
6 13 0.0004 0.031 15.0 0.3 1 23 402 425 402 425 0.95
7 13 3.5e-05 0.0027 18.4 3.0 1 23 444 466 444 466 0.97
8 13 1.2e-07 8.9e-06 26.2 2.5 1 23 473 495 473 495 0.98
9 13 4.1e-08 3.1e-06 27.6 0.7 3 23 512 532 511 532 0.98
10 13 2.4e-05 0.0018 18.9 3.2 1 23 538 560 538 560 0.99
11 13 8.2e-07 6.3e-05 23.5 1.0 2 23 567 588 566 588 0.96
12 13 1e-07 7.8e-06 26.4 1.0 1 23 594 616 594 616 0.99
13 13 0.0087 0.67 10.8 0.4 1 23 622 644 622 644 0.98

Sequence Information

Coding Sequence
ATGGCTTTACAAAACACTATTTTCAAAATTGATGACTTATGCCGGACTTGCTTATCAAAAGAAATTGAAATGCTTTCTGTTTTTGAAATTCGTTTGGGAACTATCTCATTGGACAACATAATCGCGTCAATTACAGGAATAAAGATTGAACATGGGGATGGACTGCCATCAACAATATGCAACATCTGTAAGGAAAAGGCGACTAATGCATATGAATTCAAAGCCCGCACACAAGAAGCTGATATCCAATTGCGGGGACTTTTAAAAAGAGAAAACACCGAGCAAGTCAATAGTGATAATAGTTTACCATTTGAGTCAGATGCAGTTGAGGTGAAGACTGAACAATTTGCAAGAGACAATCATGATGATTATATGGATATAGATCTCTCCCTGGCTCTTTCTAATGTTTCCGAGACTTATAATAATGTAGATACTGTTAAAAATGAAGAAGAAGATCATTGTAAAGATATATTTACAGCCCAACCAATAGAGAATGAAAATTTAAGTAGTGATATTAAGAAAAAGAATTTTATTGATGGTAATGAGACAGACAGCACCTATTGTCCCGTTTGCGGCGCTAGTTTCCACGACGCTGAAGGCCTTACGAAGCATGCCTGGGAGCAACACGGTGACCTCATGGGACCAAAAAAACGAGGCCGCCCTAAGAAGCTACTCACCAGCACAATCCTCAATAAATTGTCTGAAAATGGATACAATTTGAAATACTTACCGGATCAAAAACACAATTGTGTATTTTGTAAAGAGGATTTTAAAACAAAAGATGACCTAGTGATCCACCTCGTACAACATAAAGATGTAAAAGTTTTGAACTGTTTGCTGTGTAAGAAGATTTATCTCGAGATGAAAGATTTCGAGCGTCACAATTGCGTGCAAACTTCAGATGAATTAAATAATTTAAAACCAGCTGAACCTCCAGATGTTCCAGAAGAAGAGCGGAAGCTCAATCTGTCTACTGAAGTATTACTGCAAGACCTTCTAATGAGTAATAGAGATACGGAGTCCGGAAGCATTGATTTATGCGAGGAGTGTGGAGCTGTATTTGTATCCAGCGTGGAACTCGGCAAGCATCGTGACCGAGAACATCCTGAACTCTCCTCGCGATGCCATCTCTGCGATAAAGTATTTGCCACACTGAAGAGCGCAGCTCGTCATAGAGCGGTGTGCGCACGAGTTGAACGTTCATTCGCATGCGCATCGTGCGGGCTGCGTTTTGCGCACGAAGTGTCACTCAACAAGCACATACTGCGCGCACATACGGGACAGAGTGTGTCTGTACGTTTCATGGACCGGGACAGAGCACCTCCGCAGCATAGATGTGATACTTGCAATAGACGCTTTTACAGAAAAGATTTGCTAGCAAGGCACGCGAAGATACACAAATCGATAGACAAATGTTTCGAGTGTGACGTCTGCAATAAGAAGTTTCACAGGCGAGACAACCTGAGGGCACACATGCGTGTCCACGAGAGTACCGGTGCGGGCGTGGACGGCACGAGCAGCAGTGCCAGCCTATGCCTGTACTGCGGCCGAAGTTTCTCGAACTCTTCCAATCTCATTGTGCACATGCGCAGACATACCGGCGAGAAACCATATAAATGTGATTTTTGTGGGAAAGGCTTCCCTCGCTCCTCTGACTTGCAATGCCATCGGCGCTCTCACACTGGAGAGAAACCTTGCATATGCGGCGTGTGTGGTAAAGCATTTGCGCGCAGTAATAAGCTGTCACGACACATGCGCGTACACACCGGTATGAAGCCCTACAAATGTCCGTATTGCGAGAAGGCCTTCTCCCAAAGCAACGACCTCAAACTACACGTGCGGAGACACACGGGCGATAAGCCCTACGTCTGCGAACTATGCGGAGATCGTTTCATACAGGGGACAGCTCTACACAACCACAGACGTGCGCACGGACACTTCCCGACTGCGGCCGCGCCGCCACTGGCGCCTCTTGTCTACACCGTACAGAGCATCACACAGACGCATTAA
Protein Sequence
MALQNTIFKIDDLCRTCLSKEIEMLSVFEIRLGTISLDNIIASITGIKIEHGDGLPSTICNICKEKATNAYEFKARTQEADIQLRGLLKRENTEQVNSDNSLPFESDAVEVKTEQFARDNHDDYMDIDLSLALSNVSETYNNVDTVKNEEEDHCKDIFTAQPIENENLSSDIKKKNFIDGNETDSTYCPVCGASFHDAEGLTKHAWEQHGDLMGPKKRGRPKKLLTSTILNKLSENGYNLKYLPDQKHNCVFCKEDFKTKDDLVIHLVQHKDVKVLNCLLCKKIYLEMKDFERHNCVQTSDELNNLKPAEPPDVPEEERKLNLSTEVLLQDLLMSNRDTESGSIDLCEECGAVFVSSVELGKHRDREHPELSSRCHLCDKVFATLKSAARHRAVCARVERSFACASCGLRFAHEVSLNKHILRAHTGQSVSVRFMDRDRAPPQHRCDTCNRRFYRKDLLARHAKIHKSIDKCFECDVCNKKFHRRDNLRAHMRVHESTGAGVDGTSSSASLCLYCGRSFSNSSNLIVHMRRHTGEKPYKCDFCGKGFPRSSDLQCHRRSHTGEKPCICGVCGKAFARSNKLSRHMRVHTGMKPYKCPYCEKAFSQSNDLKLHVRRHTGDKPYVCELCGDRFIQGTALHNHRRAHGHFPTAAAPPLAPLVYTVQSITQTH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01080903;
90% Identity
iTF_01507420;
80% Identity
-