Basic Information

Insect: Udea olivalis
Gene Symbol: Hnf4
Assembly: GCA_947369235.1
Location: OX376359.1:9171521-9195215[-]

Transcription Factor Domain

TF Family: RXR-like
Domain: zf-C4|RXR-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 1.2e-63 5.5e-60 203.4 0.1 1 195 217 408 217 410 0.94

2 8 7.7e-08 0.00034 21.2 0.0 165 198 424 457 420 460 0.93

3 8 7.3e-07 0.0033 18.0 0.0 165 198 504 537 499 540 0.93

4 8 1.2e-06 0.0055 17.3 0.0 165 198 584 617 574 620 0.93

5 8 6.5e-08 0.00029 21.5 0.0 165 198 664 697 654 700 0.93

6 8 1.2e-07 0.00054 20.6 0.0 165 195 744 774 738 776 0.95

7 8 2.3e-07 0.001 19.7 0.0 166 195 791 820 787 822 0.94

8 8 4.6e-08 0.0002 22.0 0.0 165 198 836 869 832 873 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	1.2e-63	5.5e-60	203.4	0.1	1	195	217	408	217	410	0.94
2	8	7.7e-08	0.00034	21.2	0.0	165	198	424	457	420	460	0.93
3	8	7.3e-07	0.0033	18.0	0.0	165	198	504	537	499	540	0.93
4	8	1.2e-06	0.0055	17.3	0.0	165	198	584	617	574	620	0.93
5	8	6.5e-08	0.00029	21.5	0.0	165	198	664	697	654	700	0.93
6	8	1.2e-07	0.00054	20.6	0.0	165	195	744	774	738	776	0.95
7	8	2.3e-07	0.001	19.7	0.0	166	195	791	820	787	822	0.94
8	8	4.6e-08	0.0002	22.0	0.0	165	198	836	869	832	873	0.92

Sequence Information

Coding Sequence: ATGCCAGTGCTGGGCTACGAAAGCATGGCGAGCCAGGACATGTGTCTGATGGGGTTCGGGGGGGAGTACATGGTGCCCGCGCACACCTCCTGGGAGAAGGCGCAGGACCACTTCTCGGGGTACCTGAGCAGGACCAACGTGGACCACACTCTGAACTCGCACGTCAACATGAAGTACAGCGAAGACAGCGACATTCAGCTAGAGACGAGTAGCAGCGAGGCGAGCGCCGTGAGCTCGACGCCGCTGTCGCAGCACTGCGCCATCTGCGGAGACCGCGCCACCGGCAAGCACTACGGGGCGTCGTCGTGCGACGGCTGCAAGGGCTTCTTCAGGAGGAGCGTCAGGAAGAACCATCTCTACACTTGCAGATTCAGCAGAAATTGTGTGGTGGATAAAGACAAAAGAAATCAATGCAGATACTGTAGACTAAGGAAGTGCTTTAAGGCTGGCATGAAGAAAGAGGCCGTCCAGAACGAGAGAGACCGCATCAACTGCCGGCGGCCGTCTTACGAGGAGCCGGCGCAGGCCAACGGGCTGTCCGTCGTGTCATTGCTCAACGCCGAACTGCTCAGCAGGAAGGTCATCGATGAGACCATCAACGTATCAGACGCGGAGCTCAGCAACCGCAAGCTGGCGAAGATGAACGACGTGTGCGACTCCATCAAGCAGCAGCTGCTGATCCTCGTGGAGTGGGCCAAGTACATCCCCGCCTTCACCGAGCTGCACCTCGACGACCAGGTGGCCCTGCTGCGCGCGCACGCGGGCGAGCACCTGCTGCTGGGCTGCGCGCGCCGCTCGCTGCACCTCAGCGACGTGCTGCTGCTCAGCAACAGCTGCATCATCACCAAGCACAACATCGACGGTCGCATGGACATCGACATCAGCATGATCGGCATGCGCGTGATGGACGAGATCGTGAAGCCGCTGCGCGAGATCGACATCGACGACACCGAGTTCGCCTGCCTCAAGGCCATCATATTCTTCGACCCTAACGCGAAAGGCCTCTCCCAGCCGCAAAAGATAAAGCAGCTGCGCTACCAAGTGCAAATCAACTTAGAAGACTACATCAGCGACCGGCAGTACGACGGCCGCGGCCGCTTCGGCGAACTGCTGCTGTGTCTGCCGCCGCTACAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTGGCGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCCACAGCATCACATGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTGGCGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCCACAGCATCACATGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTGGCGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCCACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCTGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCAACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCTGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCAACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCTGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCAACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCTGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCAACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCCACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCCACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCAACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGTTTGCTGCAGGAGATGCTGCTGGGAGGTCAGTACACTCGGCCACAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGCGTCGTGCATGTCGACAGTTTGCTGCAGGAGATGCTGCTGGGAGGCGCCACGGCCGACGCGGCCATGGAGGAGGCGGCGCCCGCGCTGGCGCCTCCGCTCCCGCCGCCGCTGCCGCTTCCGCTGCCGGCGCCCGAGCTCTTCGACCCGATGCCCTTCAAGCAGGAGCCTAACATGTAA
Protein Sequence: MPVLGYESMASQDMCLMGFGGEYMVPAHTSWEKAQDHFSGYLSRTNVDHTLNSHVNMKYSEDSDIQLETSSSEASAVSSTPLSQHCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHLYTCRFSRNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRINCRRPSYEEPAQANGLSVVSLLNAELLSRKVIDETINVSDAELSNRKLAKMNDVCDSIKQQLLILVEWAKYIPAFTELHLDDQVALLRAHAGEHLLLGCARRSLHLSDVLLLSNSCIITKHNIDGRMDIDISMIGMRVMDEIVKPLREIDIDDTEFACLKAIIFFDPNAKGLSQPQKIKQLRYQVQINLEDYISDRQYDGRGRFGELLLCLPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGVCCRRCCWEVSTLGHSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGQYTRPQHHMADDRADTVRQAVRRGACRQFAAGDAAGRRCCWEVSTLGHSITWQMIEQIQFAKLFCVVHVDSLLQEMLLGGQYTRQQHHVADDRADTVRQAVLRRACRQFAAGDAAGRRCCWEVSTLGNSITWQMIEQIQFAKLFCVVHVDSLLQEMLLGGQYTRQQHHVADDRADTVRQAVLRRACRQFAAGDAAGRRCCWEVSTLGNSITWQMIEQIQFAKLFGVVHVDSLLQEMLLGGQYTRPQHHVADDRADTVRQAVRRRACRQFAAGDAAGRRCCWEVSTLGHSITWQMIEQIQFAKLFGVVHVDSLLQEMLLGVCCRRCCWEVSTLGNSITWQMIEQIQFAKLFGVVHVDSLLQEMLLGVCCRRCCWEVSTLGHSITWQMIEQIQFAKLFGVVHVDSLLQEMLLGGATADAAMEEAAPALAPPLPPPLPLPLPAPELFDPMPFKQEPNM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01503982;
90% Identity: iTF_01503982;
80% Identity: iTF_01503982;