Basic Information

Gene Symbol
Zfy1
Assembly
GCA_950022985.1
Location
OX465545.1:7490624-7494158[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 5.4e-05 0.0052 18.0 1.0 2 21 126 145 125 146 0.94
2 17 0.0065 0.61 11.5 0.2 1 23 177 200 177 200 0.94
3 17 0.0011 0.11 13.9 0.3 1 23 205 227 205 227 0.91
4 17 0.00017 0.016 16.5 1.5 1 23 269 292 269 292 0.95
5 17 0.00011 0.01 17.1 1.3 1 23 298 320 298 320 0.98
6 17 3.5 3.3e+02 2.9 0.4 1 23 354 377 354 377 0.86
7 17 0.00029 0.028 15.7 0.9 1 23 385 408 385 408 0.95
8 17 0.00016 0.015 16.6 3.1 2 21 521 540 520 541 0.93
9 17 0.13 13 7.4 0.0 3 23 548 569 547 569 0.95
10 17 0.0086 0.82 11.1 0.7 1 23 574 597 574 597 0.95
11 17 8.7e-06 0.00083 20.5 0.2 2 23 603 624 602 624 0.96
12 17 0.53 51 5.5 3.6 2 21 628 647 628 648 0.91
13 17 0.00023 0.022 16.0 0.3 1 23 674 697 674 697 0.95
14 17 0.00034 0.032 15.5 0.5 1 23 703 725 703 725 0.95
15 17 2.9 2.8e+02 3.1 0.1 3 23 733 753 731 753 0.96
16 17 0.0011 0.1 14.0 0.9 1 23 759 782 759 782 0.96
17 17 6.7e-05 0.0063 17.8 1.7 1 23 788 811 788 811 0.96

Sequence Information

Coding Sequence
ATGATGGCGTCGTTTCAGGTGGAGGAAGACGCCGCCTTCCCTGGAGGTGTCTGCCGCGACTGCTCGGAGGGCGCTCTGGGGGCGGCCACCTTCAGACAAAGCTGCAAGGACTCTTTCAACCAATGGTCGCAGGCCGCCTCCTTCCTAACCTCCATTGTGCCACCAAGCGGCGCCGACAAAGCCTATTACATATTCTACAGTGGTCAAGAAAGAGCCATGATTGGAGACCACGTCGCAAGCGCTGGTGATACAAAAACTGCACTTCAAAGAATTAACGCCCAATTTAAAGATACTGATTCCTCTACTGCTGTCGGTGATGTAGAAAATATAACAGAAAAGAGGGCTACCAGAAAAATAGGCCAGTTCCACATCTGCTCCTGTCCAGATTGCAAAAAGAAGTTCATTTCGCCCCAATATCTGAATGCGCATTTGAGGAATACAGCAAAAAGAGCATGCGTACTCTGCAGCTTAGTGTTACCGATGGCTAAACTAGCAGAGCATATGAGCGAAGTGCACAGATTAGTCGTATTCTCCTGCGGCCTTTGCCAGCAAATTTTCGATAGTCCTGAAGCACTGAACTCACATTTCTCGAGCAATCATGATGAAACTTCACATACTTGTAAAGTTTGTGGCAAAGGGTTCAACACGCTACGAGCCTTAGGCGCTCACGCGTATGCACACACGCTGTTTCATTGCAAATGTGGCAAAGGTTACCGTAATAGGAAATGCTATTACCACCACAGAAGCCTTTGTAGGCGTGCGGCTAAAGACAAAGCTAAATCAGCAACCAAACCAGGAACAGTTTACGAGTGTCATGATTGTGGCAATAAATATACTAAAAAGCCATCGCTACGCGTCCATATTATACAAAAACATCTTAATGTATTGCCGTTTGTCTGCGAGACATGTGGCAAGCGAACTTCGACGATTGGACATTTGAAATCACACGAGAAAGTTCATATGCTGGAGAGGAAAACATACGAATGCTATTGCGGCGCAAAAATGCGGACTGAGTTAGGTTACCAGCTCCACGTCAGAATACATTCGGGGGAAAAGCCGTATGAATGTGGCGAGTGCGGGGACAAGTTTCTATCTGCTTCAAGGCGGTTAGACCATATAAAACGGAAGCACAGAAGCGCTGAACAAATGCCTCATGCCTGTGAAGAATGTTCTAGTAGATTCGTCAGACCGTCCGAGTTAAAAAAGCATAACATGACGGTCCATTCGAAAGTGGAAGAAGACTCGAACCTTCCCCTAGGCGTATGCGCAACGTGTGCCGCCAGCGCCCTCTCTGCGCAGGAGTTCCGAACTATGACACAAAACTCACAAAAATTGTGGTATAAAGCTGTGACGTCTCTACGAGATATACCCAAATCAGCCTCCTCCGGTGTCAAATCCCTATGTGCGTTTGTAAAGCACGACAATTTATCCATTCATGTCGTAAAGGACTTTGCGAGTGGAAATGCTAAAACTTTAATGACTAGACTCAAAAATAGGCTTAAAAGAAAACCAAATAGCTCTGAAAAGAAGCCAAGAATGACACGCACCGGACAGGCTTGCAACTGCCCTGATTGTGGCAAATCGTTCTACAGTCCTTTCTACTTGTGTCAGCATTTAAACAACAGTGGTCAGAAGGAGGCCTGTACTATTTGCGGCCTCGTCCTGCCTAGAGGTGAAGAGATGAAGATCCATATGGTGTCGGTTCACGGAGAAAAAATATTCACGTGTGAAAAATGCCCTCAACTCTTTACAAGCAAGTGGCGGTTAGACAAGCACGTCGCGAAGTCGCACAAACCTGGTTCGCTGACGTGCTCAGACTGCGGGCGCACGTTTCCTAGGAAAGCGACGTTTGAAGCGCACGCACAGATGCACGCAGTCCGCACCTGCAGAACATGTGGTCGGCAGTTCACTAACCGCCTCTGTTATAGAGAGCACAGATCTAAGTGTGAACCCGAGGCTCGACCCGACACTCAGTCCATGCCGCGAAATAAACGTTCCAACATACGTGATCCGGCTACTTTCACGTGCGATTACTGCGGAAAAACGTATTTATCACGACCGCAATTGAAAAACCATATTATTTGGATTCACATGGATGTGCGACCACATCAGTGCCAGTGGTGTGGGAAAAGGTTCTATACGCCAGCCCGCTTGGCGGAACATACAGTTGTACACACGCGGGAACGCAACTTCGGATGCGATGTTTGCGGAGCGAAACTGGTCTCACGAATGGCTGCTATTTACCACAAAAGACGCCACACTGGCGAGAAGCCCTACACCTGTGAAGATTGTGGTGAGAAGTTCATCTCTTCGTCTCGTAGAACGGAGCACGCGAAGCGTCGCCATGGCAAGGGACCTTTCTTCAACTGTGAACATTGCTCTGCTATTTTTGTTCGTAACTCTGAATTGAAAAAGCATTTGGAAAAGTCACATGGCTTGAAAGGTGTCGAAAAGGCAGTTTTACGTCCACTGATAAAAAGTCAACCCACTCTGAAGGATAATGCTGAAAAAATTCAAGAAGATATTATTGGAGCGTCCGAAATAATGGTTATCGACAGAACGGAGGGGGCTACGCTGGCGCTTTCTGATTATAAAATGGAACCGCTTGTTAGTTGA
Protein Sequence
MMASFQVEEDAAFPGGVCRDCSEGALGAATFRQSCKDSFNQWSQAASFLTSIVPPSGADKAYYIFYSGQERAMIGDHVASAGDTKTALQRINAQFKDTDSSTAVGDVENITEKRATRKIGQFHICSCPDCKKKFISPQYLNAHLRNTAKRACVLCSLVLPMAKLAEHMSEVHRLVVFSCGLCQQIFDSPEALNSHFSSNHDETSHTCKVCGKGFNTLRALGAHAYAHTLFHCKCGKGYRNRKCYYHHRSLCRRAAKDKAKSATKPGTVYECHDCGNKYTKKPSLRVHIIQKHLNVLPFVCETCGKRTSTIGHLKSHEKVHMLERKTYECYCGAKMRTELGYQLHVRIHSGEKPYECGECGDKFLSASRRLDHIKRKHRSAEQMPHACEECSSRFVRPSELKKHNMTVHSKVEEDSNLPLGVCATCAASALSAQEFRTMTQNSQKLWYKAVTSLRDIPKSASSGVKSLCAFVKHDNLSIHVVKDFASGNAKTLMTRLKNRLKRKPNSSEKKPRMTRTGQACNCPDCGKSFYSPFYLCQHLNNSGQKEACTICGLVLPRGEEMKIHMVSVHGEKIFTCEKCPQLFTSKWRLDKHVAKSHKPGSLTCSDCGRTFPRKATFEAHAQMHAVRTCRTCGRQFTNRLCYREHRSKCEPEARPDTQSMPRNKRSNIRDPATFTCDYCGKTYLSRPQLKNHIIWIHMDVRPHQCQWCGKRFYTPARLAEHTVVHTRERNFGCDVCGAKLVSRMAAIYHKRRHTGEKPYTCEDCGEKFISSSRRTEHAKRRHGKGPFFNCEHCSAIFVRNSELKKHLEKSHGLKGVEKAVLRPLIKSQPTLKDNAEKIQEDIIGASEIMVIDRTEGATLALSDYKMEPLVS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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