Tdic013161.1
Basic Information
- Insect
- Trypoxylus dichotomus
- Gene Symbol
- run
- Assembly
- GCA_014905495.1
- Location
- BNES01000048.1:4270484-4272533[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 4.3e-75 2.7e-71 237.7 0.0 1 129 19 147 19 147 0.99
Sequence Information
- Coding Sequence
- ATGCATCTACCGCAGCAGACGACGGTACCGAAAATGATGGATATGTACACCGCAATGCAGGAAACTTTACAAGAATATCACGGGGAATTGGTGCAAACGGGAAGTCCGGCGATTTTGTGCAGTGTTCTTCCAACTCATTGGCGGTCGAATAAAAGTTTGCCGATTGCTTTCAAAGTGGTCGCTTTGGACGACGTTCAGGACGGTACGGTTGTGACTCTGAAAGCCGGAAACGATGAAAACTACTGCGCCGAATTAAGGAATTGCACGGCGGTGATGAAAAATCAAGTCGCCAAATTCAACGATCTTCGCTTCGTAGGAAGAAGCGGACGAGGGAAATCCTTCACGTTGACGATAGTCATCAGTTCGGCGCCTTTCCAAGTCGCCACCTATAATAAGGCGATTAAAGTGACCGTAGATGGACCTAGGGAACCTCGAACGAAATCGAATTACCAATATGGATACGGTCTTCCCGGAATGCCTGGAGCGTTCAACCCGTTCTTACTAAACCCTGGATGGTTAGACGCTGCCTATATGTCGTATGCCTGGCCGGATTATTTTCGAAATAGAACTAATACCTTGTCAGCACAACAGAACAACATTCccttattaaaaaCGACTACCTCGCAACTACCAGGGCATCTTCATCCACCAAACGAATTCTACTTACCCCACGCTGGAAGCCCACCGTCCTCCTTCCACGCTAATTTCTTACCAGCCAGCGGCCTTCTTCCTCAATTCCCAGCGGAGATTCCAAAGGTACCAACATTGGATAATCTGCACATCCGACCGGTAGGATCATCAACAATGGAGCAACTCAATCTGCGGCTATCTCCCATGTCAAATTCGCATAGCATAAGTCCTCAATTAAGCTTGAGTAATAAAGAGAGCGACTCACGAATACACTCGACGCAAGACCAATCCACTTCCGAAGCTTCCGATGAAGAAGACATTGACGTGGTGAAGTCAGCGTTTCAACCTATCAAACCAGCAAGCGTTATGCTTCAAGAAGTCCAGCATCCGGATTCGACTGTACAAGATAAAGAACCTCAGACTAGGTGCGAGTTGAAAGCCACTAAGAAGCCTTTGAGTGCTTTAAGTCCTAAATCGCCTTCCACTAAAATCCATTCAAATCCAAATACTACGAAACCTGTGTGGAGACCGTATTAG
- Protein Sequence
- MHLPQQTTVPKMMDMYTAMQETLQEYHGELVQTGSPAILCSVLPTHWRSNKSLPIAFKVVALDDVQDGTVVTLKAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISSAPFQVATYNKAIKVTVDGPREPRTKSNYQYGYGLPGMPGAFNPFLLNPGWLDAAYMSYAWPDYFRNRTNTLSAQQNNIPLLKTTTSQLPGHLHPPNEFYLPHAGSPPSSFHANFLPASGLLPQFPAEIPKVPTLDNLHIRPVGSSTMEQLNLRLSPMSNSHSISPQLSLSNKESDSRIHSTQDQSTSEASDEEDIDVVKSAFQPIKPASVMLQEVQHPDSTVQDKEPQTRCELKATKKPLSALSPKSPSTKIHSNPNTTKPVWRPY*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01123464; iTF_00956085; iTF_01120651; iTF_00433818; iTF_00987589; iTF_00064955; iTF_00626844; iTF_01252509; iTF_00307346;
- 90% Identity
- iTF_00626844;
- 80% Identity
- -