Taea019466.1
Basic Information
- Insect
- Troides aeacus
- Gene Symbol
- YTHDC2
- Assembly
- GCA_033220335.2
- Location
- CM067289.1:8663567-8696317[+]
Transcription Factor Domain
- TF Family
- HSF
- Domain
- HSF_DNA-bind domain
- PFAM
- PF00447
- TF Group
- Helix-turn-helix
- Description
- Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 5 0.0081 45 5.3 0.0 37 59 416 438 388 457 0.88 2 5 0.0086 49 5.2 0.0 37 59 708 730 691 749 0.87 3 5 0.0086 49 5.2 0.0 37 59 1000 1022 983 1041 0.87 4 5 0.0086 49 5.2 0.0 37 59 1292 1314 1275 1333 0.87 5 5 0.0082 46 5.2 0.0 37 59 1548 1570 1523 1589 0.88
Sequence Information
- Coding Sequence
- ATGAGCTCAAAGAGAGGAAAGAGGAATACAGGAAATAAACATTTTCCCATAGCTGAATCAGTCAGCATAGCTTTGAAAATACAACTAGATAAATTTCTCAACGACGAAAATGAGACTGAACTTAAGTTTCCTACGTTTCTATCAGCCCAAGAACGTGGTTTCATTCATGAGGCGGTTGCCAAGTTGGGTCTTAAATCGAAATCGCGCGGGAAAGgTGTCAACagatatttaactgtttataagAGAGTTGGCTCCACAATTATTCAGAATAATGCAAAGCTCATATTAGATTCAAATATGAGATGCAGCATAGTGGAGCTGTTAACAACGTTCCCACTTACTGCTAAAGAGAGGGATGACCTTAGTTGCTGTCCTGATAAGGAGAGGAGTCCTCAGTTGTCACACAAGTCACTGGGCCAGTTGAATAATGGAGTTGCACaggTGCCAAACACTACATACAATCCAGATTTAATTAAGTTCAGGGAGAAGTTACCAGTGTATGAGCAGAGGCAGGAATTGATTAATGCTATCACACACAATCAgGTGATAATAGTTGCGGGTGCGACTGGATGCGGTAAGACTACACAACTTCCCCAACTCGTGTTGGACTGGTGCCAGGAGCACAAGCAGCCGGCGCGTATATATTGCACACAGCCACGGAGAATCTCTGCTGTGTCAGTAGCTGAGAGAgtgGCATTTGAGCGTATGGAGAAAATAGGACAATCAATTGGTTATCAGATCCGACTTGAATCCCGGGTCAGTCCTCGTACAGTGCTCACTTACTGCACGAATGGAGTGCTGCTGCGGACATTAATGGCTGGAGACAGTTCCCTGACTGGCGTGAGTCACGTATTCGTGGACGAGGTGCACGAGAGAGACAAATTCAGTGATTTCCTGCTGATCGCGCTCCGGGACGCCCTGCCGCGCTTCAAAGACCTCAAGTTACTCCTCATGTCGGCAACATGCGACACCCAAATATTCTCAAGATATTTCAACAACTGTCCCGTAGTTACTATCCCTGGTCGCTTGCACGACGTACAACGGTACTACCTGGAGGACATCCTCAAGATGACGATTTATCGAAGTAAGAAAATGATTAAAGCGGAGAAGGATCTCAAACACAAGTTAACCACCGGACACAGCTACTGGTCTCATCTAGAAAATCAGAAGCCGAGCTCTGAAGAGAACAGTAGTATTAAGGAAGAGAAAGAGAACGCAATTGATCCAGCTCTGCAGGCTGATATGGATGAGTTTCTAGAAGAGTGCTTTAAAGAAGGAAGTATGGACTCGTTCTGTCAAATACTGTACATGTACCTGTCGGAGGGTGTACCGGTGCAGTGCTCGCAGTCGCGCACTGGTCGCACCGGGCTTATGGCGGCCGCCGTCCACGGCTTGTCCGAGACAGCCGCTCATATCCTGCACATAGAGGTTGAGAGAGATCAAATCGACACTGGAGCGCAAAGAATTATAAACACTTGTTCACACCTGTTAAAAGAGTTCAGAAACGACAATCGTAAGGTTCTAGCTACATCACAAATGCGAGAGTTTATGGATGCTGTGATTGATCTTATTGATGCATACTTAAAAGCTGTATGCAAGGTTCATAGTGAACTTAAAGCTTTGAGAGTAAAGAGAGCACTTGATATCAGAAAATTGTCACGATTGGAACCCCCTCAATCTAAACCAATTATTCTTAACACATTGGTTAATGAGaaaattgtagaaaataaaGAGGGAAAAGAATTAAATGATACTGAATCAAATGAAACTGATTTGACAAAGACAAAGATGCATTTATCTGAGAATGATACTGCAATTTTGTCAGATGAAGGCGAGTTGGATGCTGAAGAACTTCAGATGTATGAGTCAGAAAATCTTCAGCTGTTGAATGAATTAAATAGCATGACTGAAGaagtaaaacaaattgaaagtaAGAAATCAATAAAGCTGTACGCCGCCGCATTATGGATTACCTGCCCGGGCCAGGTTGTCAGCGGCAGTTGGCTCTGGGCTGTTCAGTGTAACACACAAAAATCAAATCAGAAGCCGAGCTCTGAAGAGAACAGTAGTATTAAGGAAGAGAAAGAGAACGCAATTGATCCAGCTCTGCAGGCTGATATGGATGAGTTTCTAGAAGAGTGCTTTAAAGAAGGAAGTATGGACTCGTTCTGTCAAATACTGTACATGTACCTGTCGGAGGGTGTACCGGTGCAGTGCTCGCAGTCGCGCACTGGTCGCACCGGGCTTATGGCGGCCGCCGTCCACGGCTTGTCCGAGACAGCCGCTCATATCCTGCACATAGAGGTTGAGAGAGATCAAATCGACACTGGAGCGCAAAGAATTATAAACACTTGTTCACACCTGTTAAAAGAGTTCAGAAACGACAATCGTAAGGTTCTAGCTACATCACAAATGCGAGAGTTTATGGATGCTGTGATTGATCTTATTGATGCATACTTAAAAGCTGTATGCAAGGTTCATAGTGAACTTAAAGCTTTGAGAGTAAAGAGAGCACTTGATATCAGAAAATTGTCACGATTGGAACCCCCTCAATCTAAACCAATTATTCTTAACACATTGGTTAATGAGaaaattgtagaaaataaaGAGGGAAAAGAATTAAATGATACTGAATCAAATGAAACTGATTTGACAAAGACAAAGATGCATTTATCTGAGAATGATACTGCAATTTTGTCAGATGAAGGCGAGTTGGATGCTGAAGAACTTCAGATGTATGAGTCAGAAAATCTTCAGCTGTTGAATGAATTAAATAGCATGACTGAAGaagtaaaacaaattgaaagtaAGAAATCAATAAAGCTGTACGCCGCCGCATTATGGATTACCTGCCCGGGCCAGGTTGTCAGCGGCAGTTGGCTCTGGGCTGTTCAGTGTAACACACAAAAATCAAATCAGAAGCCGAGCTCTGAAGAGAACAGTAGTATTAAGGAAGAGAAAGAGAACGCAATTGATCCAGCTCTGCAGGCTGATATGGATGAGTTTCTAGAAGAGTGCTTTAAAGAAGGAAGTATGGACTCGTTCTGTCAAATACTGTACATGTACCTGTCGGAGGGTGTACCGGTGCAGTGCTCGCAGTCGCGCACTGGTCGCACCGGGCTTATGGCGGCCGCCGTCCACGGCTTGTCCGAGACAGCCGCTCATATCCTGCACATAGAGGTTGAGAGAGATCAAATCGACACTGGAGCGCAAAGAATTATAAACACTTGTTCACACCTGTTAAAAGAGTTCAGAAACGACAATCGTAAGGTTCTAGCTACATCACAAATGCGAGAGTTTATGGATGCTGTGATTGATCTTATTGATGCATACTTAAAAGCTGTATGCAAGGTTCATAGTGAACTTAAAGCTTTGAGAGTAAAGAGAGCACTTGATATCAGAAAATTGTCACGATTGGAACCCCCTCAATCTAAACCAATTATTCTTAACACATTGGTTAATGAGaaaattgtagaaaataaaGAGGGAAAAGAATTAAATGATACTGAATCAAATGAAACTGATTTGACAAAGACAAAGATGCATTTATCTGAGAATGATACTGCAATTTTGTCAGATGAAGGCGAGTTGGATGCTGAAGAACTTCAGATGTATGAGTCAGAAAATCTTCAGCTGTTGAATGAATTAAATAGCATGACTGAAGaagtaaaacaaattgaaagtaAGAAATCAATAAAGCTGTACGCCGCCGCATTATGGATTACCTGCCCGGGCCAGGTTGTCAGCGGCAGTTGGCTCTGGGCTGTTCAGTGTAACACACAAAAATCAAATCAGAAGCCGAGCTCTGAAGAGAACAGTAGTATTAAGGAAGAGAAAGAGAACGCAATTGATCCAGCTCTGCAGGCTGATATGGATGAGTTTCTAGAAGAGTGCTTTAAAGAAGGAAGTATGGACTCGTTCTGTCAAATACTGTACATGTACCTGTCGGAGGGTGTACCGGTGCAGTGCTCGCAGTCGCGCACTGGTCGCACCGGGCTTATGGCGGCCGCCGTCCACGGCTTGTCCGAGACAGCCGCTCATATCCTGCACATAGAGGTTGAGAGAGATCAAATCGACACTGGAGCGCAAAGAATTATAAACACTTGTTCACACCTGTTAAAAGAGTTCAGAAACGACAATCGTAAGGTTCTAGCTACATCACAAATGCGAGAGTTTATGGATGCTGTGATTGATCTTATTGATGCATACTTAAAAGCTGTATGCAAGGTTCATAGTGAACTTAAAGCTTTGAGAGTAAAGAGAGCACTTGATATCAGAAAATTGTCACGATTGGAACCCCCTCAATCTAAACCAATTATTCTTAACACATTGGTTAATGAGaaaattgtagaaaataaaGAGGGAAAAGAATTAAATGATACTGAATCAAATGAAACTGATTTGACAAAGACAAAGATGCATTTATCTGAGAATGATACTGCAATTTTGTCAGATGAAGGCGAGTTGGATGCTGAAGAACTTCAGATGTATGAGTCAGAAAATCTTCAGCTGTTGAATGAATTAAATAGCATGACTGAAGaagtaaaacaaattgaaaATCAGAAGCCGAGCTCTGAAGAGAACAGTAGTATTAAGGAAGAGAAAGAGAACGCAATTGATCCAGCTCTGCAGGCTGATATGGATGAGTTTCTAGAAGAGTGCTTTAAAGAAGGAAGTATGGACTCGTTCTGTCAAATACTGTACATGTACCTGTCGGAGGGTGTACCGGTGCAGTGCTCGCAGTCGCGCACTGGTCGCACCGGGCTTATGGCGGCAGCCGTCCACGGCTTGTCCGAGACAGCCGCTCATATCCTGCACATAGAGGTTGAGAGAGATCAAATCGACACTGGAGCGCAAAGAATTATAAACACTTGTTCACACCTGTTAAAAGAGTTCAGAAACGACAATCGTAAGGTTCTAGCTACATCACAAATGCGAGAGTTTATGGATGCTGTGATTGATCTTATTGATGCATACTTAAAAGCTGTATGCAAGGTTCATAGTGAACTTAAAGCTTTGAGAGTAAAGAGAGCACTTGATATCAGAAAATTGTCACGATTGGAACCCCCTCAATCTAAACCAATTATTCTTAACACATTGGTTAATGAGaaaattgtagaaaataaaGAGGGAAAAGAATTAAATGATACTGAATCAAATGAAACTGATTTGACAAAGACAAAGATGCATTTATCTGAGAATGATACTGCAATTTTGTCAGATGAAGGCGAGTTGGATGCTGAAGAACTTCAGATGTAG
- Protein Sequence
- MSSKRGKRNTGNKHFPIAESVSIALKIQLDKFLNDENETELKFPTFLSAQERGFIHEAVAKLGLKSKSRGKGVNRYLTVYKRVGSTIIQNNAKLILDSNMRCSIVELLTTFPLTAKERDDLSCCPDKERSPQLSHKSLGQLNNGVAQVPNTTYNPDLIKFREKLPVYEQRQELINAITHNQVIIVAGATGCGKTTQLPQLVLDWCQEHKQPARIYCTQPRRISAVSVAERVAFERMEKIGQSIGYQIRLESRVSPRTVLTYCTNGVLLRTLMAGDSSLTGVSHVFVDEVHERDKFSDFLLIALRDALPRFKDLKLLLMSATCDTQIFSRYFNNCPVVTIPGRLHDVQRYYLEDILKMTIYRSKKMIKAEKDLKHKLTTGHSYWSHLENQKPSSEENSSIKEEKENAIDPALQADMDEFLEECFKEGSMDSFCQILYMYLSEGVPVQCSQSRTGRTGLMAAAVHGLSETAAHILHIEVERDQIDTGAQRIINTCSHLLKEFRNDNRKVLATSQMREFMDAVIDLIDAYLKAVCKVHSELKALRVKRALDIRKLSRLEPPQSKPIILNTLVNEKIVENKEGKELNDTESNETDLTKTKMHLSENDTAILSDEGELDAEELQMYESENLQLLNELNSMTEEVKQIESKKSIKLYAAALWITCPGQVVSGSWLWAVQCNTQKSNQKPSSEENSSIKEEKENAIDPALQADMDEFLEECFKEGSMDSFCQILYMYLSEGVPVQCSQSRTGRTGLMAAAVHGLSETAAHILHIEVERDQIDTGAQRIINTCSHLLKEFRNDNRKVLATSQMREFMDAVIDLIDAYLKAVCKVHSELKALRVKRALDIRKLSRLEPPQSKPIILNTLVNEKIVENKEGKELNDTESNETDLTKTKMHLSENDTAILSDEGELDAEELQMYESENLQLLNELNSMTEEVKQIESKKSIKLYAAALWITCPGQVVSGSWLWAVQCNTQKSNQKPSSEENSSIKEEKENAIDPALQADMDEFLEECFKEGSMDSFCQILYMYLSEGVPVQCSQSRTGRTGLMAAAVHGLSETAAHILHIEVERDQIDTGAQRIINTCSHLLKEFRNDNRKVLATSQMREFMDAVIDLIDAYLKAVCKVHSELKALRVKRALDIRKLSRLEPPQSKPIILNTLVNEKIVENKEGKELNDTESNETDLTKTKMHLSENDTAILSDEGELDAEELQMYESENLQLLNELNSMTEEVKQIESKKSIKLYAAALWITCPGQVVSGSWLWAVQCNTQKSNQKPSSEENSSIKEEKENAIDPALQADMDEFLEECFKEGSMDSFCQILYMYLSEGVPVQCSQSRTGRTGLMAAAVHGLSETAAHILHIEVERDQIDTGAQRIINTCSHLLKEFRNDNRKVLATSQMREFMDAVIDLIDAYLKAVCKVHSELKALRVKRALDIRKLSRLEPPQSKPIILNTLVNEKIVENKEGKELNDTESNETDLTKTKMHLSENDTAILSDEGELDAEELQMYESENLQLLNELNSMTEEVKQIENQKPSSEENSSIKEEKENAIDPALQADMDEFLEECFKEGSMDSFCQILYMYLSEGVPVQCSQSRTGRTGLMAAAVHGLSETAAHILHIEVERDQIDTGAQRIINTCSHLLKEFRNDNRKVLATSQMREFMDAVIDLIDAYLKAVCKVHSELKALRVKRALDIRKLSRLEPPQSKPIILNTLVNEKIVENKEGKELNDTESNETDLTKTKMHLSENDTAILSDEGELDAEELQM
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -