Basic Information

Gene Symbol
-
Assembly
GCA_030523145.1
Location
JAQQRF010000344.1:65276-68448[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 1.7e-05 0.0019 19.0 4.4 1 23 232 254 232 254 0.97
2 10 1.2e-05 0.0013 19.5 0.5 2 23 264 285 263 285 0.96
3 10 3 3.3e+02 2.6 0.4 8 22 377 391 370 394 0.82
4 10 5.9e-07 6.6e-05 23.6 1.1 1 23 427 450 427 450 0.97
5 10 5.1e-06 0.00057 20.7 1.4 1 23 476 498 476 498 0.98
6 10 0.00014 0.016 16.1 4.0 1 23 512 534 512 534 0.96
7 10 0.00014 0.015 16.2 4.7 1 23 540 562 540 562 0.98
8 10 0.0012 0.13 13.2 3.2 1 23 568 590 568 590 0.98
9 10 4.1e-05 0.0046 17.8 6.5 1 23 596 618 596 618 0.98
10 10 0.0027 0.3 12.1 2.7 1 21 624 644 624 650 0.92

Sequence Information

Coding Sequence
ATGGATATGCCAGTGAAGGAGATCGTTTTTTTGGAGCAAGCCAGGGTGTGCAGAGTTTGTCTACAAGACGATGAAAATAGCAAGTCCATTTTCAACGACAAAAGTAGTCTTAGTTTGGTGCAAAAACTAGTCTATTATGGGGGCATTGAGattttagaGAACGATGGACTTCCAGACAGAATTTGTTTGCAATGCATCTCAAAGATTGACTTGGCTCATGAATTCCGAATACAATGTCAAATTGCAGATCAACGTCTGAGACAAATGTTTGGAAAACcgcaaacaatttattcgtTTTCAACATTGACGGATACAAAGgacaaaaattgtcaaatcaaTTCGGCGGGACCGTCAAAAAGTCGTCCACTTGATAATGAAGAGCCAAAGTGCGGTATAGAAAATAACGATGATAAAGTTTGCAACTCAAATTTAGTTTCCACGTTGTGCCCTGAAGCAGATCAAATCGTCGagaaggaaaacaaaattgaagacGAAGCTTGTTCACAGAAAGAGATGCTGAAAACCCGAAGAGCTTCGGTTTTTAAACGCGTAACTTCGATGGAGAATTTGAAGAGCCACAGAGAAAGACAAAGGCAGTATATCAAAAAGAGTTCCAAGCTTGACGACTCGAAGAGGAAAAAGATAACGACAGAAACCGATGACGAATGCATAACCACTTGTGATCAAGGTGGATTCAAGTGTGAGCATTGCGATAAACAGTTCAGCCAGCAGGATAAATTATTTAGCCATGAAAAATTGCACGAGAGCAAGGTCAAGTGCGAGCCAGTGGTATGTCAAATTTGTGACAAAAGTTTTCGCAAGAACGACACTATGGTGAGACACTTGAATTTGCATAAGAAAGCAAATCCGAAGGAAGTGTTTTCTATACTAAAAGAGATGAGGGATAAAAGGAGGCTGGAAAACAACCCGGTGAGAACAGAGATGGAAGGCAATTGTTCGGATGAGAACAAAGAGGAATTGGATGTCGAGCACATAGACTTTGGCAGAGGAAATCCTGAAGATAACGAGGCACTTGATGATTCGAATACATCTGTTTATGGTTGTAATTATCAGAGCTCTTTGGAAAATATTAAAGATAAGAAGACGTTTTCCTGTAATGtctataatataaaattcaatcggCAAGATAAATTGAACAGCCACAAAGAAAAACGTGACCACATCCCATCAGAAAAACCTCCGGATGATAAATCTGCTTTGAAACTTATCAACAGTTGGATCAGGGAGGAACTGATCTCCGACAACGACAACAAAACCTTTTCCTGTGAAATTTGCGGAAAATCTTATGCGACAAGAAAATCTCTAACGAAACATCGTTCGACCGTTCACGATGATTCTACTGAAAACAAGAATCTAGAAGACTGCTCCTGTCCTGAGAAAGCGAAAACTGAAAAACCGAAACCATATTCTTGTACAGAATGCAATAAGTCGTTCGAAAAGGAAGGCAAGCTTGAGAAGCACAAGAGGATCCATGAAAGAAGCAAGGAGCAGCAGGACACGAATTTCAAAAGGTTTCTCTGTCACATTTGTAGTAAGACTTTCAGACAAAATACTGGCCTGATGTTTCACATGAGGACTCACACTGGATACAAGCCTCATGTTTGTAAATACTGCGGCAGAGGATTTACCTCAAACTCCAACTGTATCAATCATGAAAGAACTCATACAGGGGATAGGCCATTCGTCTGTCACTTCTGCAGTGCAGCTTTCGCGAAATCCTGTACTCTCAAAGCTCACATCACAACTCACACGGGAGAAGCAAATTATCACTGTAAAACCTGTGGCAAGTCATTCCGCAGACTCAAGTACTTGAAAGAGCACAGGTTTACTCATACTGGTGAAAAACCTTACGCTTGCAAACTGTGTGGTACTGCGTACAGTCATTCCGGAAGTTTGTTCGTGCATGAGAAAAAGTGTAAGGCACACTTCAACAACACTTCTTTTCAATCACCAGTAGGACAAAATAGTGTTGGAACGTTCTGTCAGCAGGGGGAGGTAACGATCGGAGTCACCCAAGCTGCTCCCTTGATAACGACCCTGCCCGTTTCGAATCAGATTGCTGGAGAGATTAGTAATGTGATGCATGGAGAGAAAGGGTTTGTGGACATGCAGAGGACTACTCAGATGGCAATGGGGGAGAATCCCACATTGGTTCATCCTGGTACCGAAGTCCACGAGATTCAAACTGTAAAGAACTTTACCATTattggacaaatttttcacggctga
Protein Sequence
MDMPVKEIVFLEQARVCRVCLQDDENSKSIFNDKSSLSLVQKLVYYGGIEILENDGLPDRICLQCISKIDLAHEFRIQCQIADQRLRQMFGKPQTIYSFSTLTDTKDKNCQINSAGPSKSRPLDNEEPKCGIENNDDKVCNSNLVSTLCPEADQIVEKENKIEDEACSQKEMLKTRRASVFKRVTSMENLKSHRERQRQYIKKSSKLDDSKRKKITTETDDECITTCDQGGFKCEHCDKQFSQQDKLFSHEKLHESKVKCEPVVCQICDKSFRKNDTMVRHLNLHKKANPKEVFSILKEMRDKRRLENNPVRTEMEGNCSDENKEELDVEHIDFGRGNPEDNEALDDSNTSVYGCNYQSSLENIKDKKTFSCNVYNIKFNRQDKLNSHKEKRDHIPSEKPPDDKSALKLINSWIREELISDNDNKTFSCEICGKSYATRKSLTKHRSTVHDDSTENKNLEDCSCPEKAKTEKPKPYSCTECNKSFEKEGKLEKHKRIHERSKEQQDTNFKRFLCHICSKTFRQNTGLMFHMRTHTGYKPHVCKYCGRGFTSNSNCINHERTHTGDRPFVCHFCSAAFAKSCTLKAHITTHTGEANYHCKTCGKSFRRLKYLKEHRFTHTGEKPYACKLCGTAYSHSGSLFVHEKKCKAHFNNTSFQSPVGQNSVGTFCQQGEVTIGVTQAAPLITTLPVSNQIAGEISNVMHGEKGFVDMQRTTQMAMGENPTLVHPGTEVHEIQTVKNFTIIGQIFHG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01493801;
90% Identity
-
80% Identity
-