Tbro003563.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Trissolcus brochymenae
Gene Symbol
SMAD4
Assembly
GCA_030523145.1
Location
JAQQRF010000101.1:122080-127040[+]

Transcription Factor Domain

TF Family
MH1
Domain
MH1 domain
PFAM
PF03165
TF Group
Unclassified Structure
Description
The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [2, 1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.7e-44 4e-40 136.7 0.4 2 103 61 161 60 161 0.98

Sequence Information

Coding Sequence
ATGGTCGGACTCGCGGCCGGGGGAGGCCACCTTTACCCCTCGTCCCCGATGCAGTCCAACCCTGAATtgAGGGAAATGACTGGAATGACACCTAGTGCACCGACCAGCGCTGATGCTTGCTTAAGCATAGTGCATTCTTTGATGTGCCACCGTCAAGGAGGGGAGAGTGAAGGATTCAGTAAACGTGCCATCGAGTCGCTTGTCAAAAAACTTAAAGAAAAGCGCGACGAGCTGGACAGTTTGATAACTGCTATCACGACGAACGGCGCACACCCGAGCAAATGTGTCACAATTCAAAGAACCCTCGACGGTCGGCTCCAGGTTGCCGGTCGCAAAGGGTTTCCGCACGTAATTTACGCACGAATATGGCGCTGGCCGGATCTCCACAAGAACGAACTCAAGCACGTGAAATATTGCCAATTTGCTTTTGATCTCAAATGTGATTCTGTCTGCGTCAATCCGTACCACTATGAACGGGTCGTGTCCCCCGGAATAGACCCATTCTTTACAGACTTGTCCGGGCTGACACTGCAGTCGGGAGTGGGCGTGGGGCCTGGTGGACGACTGGTCAAGGATGAGTACACGGTGGGAGGCGGCAGCACCAGTTCCGGGGCTGGCGTCGGAGTTGGCGTGGGCGTCGGGGTCGGCGTTTCCGCGGGGATGGACGTCGACAACGAGATGAACCAGACGATCCAACACCATCCGCCACCTAGTCAGCCTCCTGCCCCGAGCAACTCGCAGCAAACACCGCAGCCCTTCATCCCTGGAATGGCGCCGCCCAATCCAGCTAATGGTGAGGGAGTATTTAGTGGGGGCGGGGTGCCGAATAGCGCTAACTCACACCCCAAGTTGGAAGACAGTAGTTGCCCCCAACCGACATGGATCCCCACGCCTCATCATTCCTCAACTCGAAACATGCACCATTCAGTTGTACACTCAATGAGTCACACCGTAGGTAACCAGCAGCAGCCACTGAACCCGCCGTCGAGCGGCAACGGAAGTGGCCAGATGTTGAGTCCAGCCCAGGCCCAAACCGGGGAATCCTTTTATAGCACCGCGTCACCACCGCAAGATCTCAATCAACCTCCCACCGCTGTCGATGCGTTAACAGCCTCGCTAAgtGGTAACCAAAGTTCTCCTGTCTCGCCGGTGCACCTTCAGCACCACCAAAATGGATTCGCCGTGGCGACTGTCGCCAATCCGTACAATTCTGGAGCCCCTCAATGGACCGGGGCGAACACTCTGACTTATACGCAAAGCATGCAACCACCCGATCATCGACATATGCACGCCACATCGTATTGGGGTGGACATGGCGAGGTCGGTGGAAGCGTGGGTGGATTGTTGTCAAACCAACCAGCACCAGAGTACTGGTGTTCTGTAGCCTATTTTGAGCTTGACACCCAAGTTGGTGAAACTTTCAAAGTCAGCAGCAGTTGTCCGACTGTGACCGTTGATGGATATGTGGACCCTAGCGGCGGCAACAGATTTTGCCTCGGAGCCTTGAGTAATGTCCATCGTACTGAACAGAGCGAGAGAGCTCGACTTCACATAGGTAAAGGAGTAGTCTTAGATCTAAGAGGAGAGGGCGACGTTTGGCTGAGGTGTCAGAGTGAACACAGCGTTTTTGTGCAATCATATTATTTGGACCGAGAAGCGGGACGCTCGCCGGGCGACGCGGTGCACAAAATTTATCCCTCGGCGTACATTAAGGTGTTTGATTTGCGACAATGTCACAAGCAGATGCGAGGCCAGGCAGCAACCGCTCAAGCAGCAGCCGCTGCACAAGCCGCTGCCGTTGCAGGACATCTCACCCATGGGACACCAATTACTAAAAGTCTCAGCGCAGCTGCGGGAATTGGTGTTGATGATCTACGTCGATTGTGCATATTACGACTCAGTTTCGTCAAAGGTTGGGGTCCGGATTATCCCAGACAAAGCATCAAGGAGACTCCTTGTTGGATAGagGTACACTTGCACCGAGCGCTTCAACTGTTGGACGAAGTGCTACACACAATGCCAATCGACGGACCACGAGGGATCGAGTAA
Protein Sequence
MVGLAAGGGHLYPSSPMQSNPELREMTGMTPSAPTSADACLSIVHSLMCHRQGGESEGFSKRAIESLVKKLKEKRDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARIWRWPDLHKNELKHVKYCQFAFDLKCDSVCVNPYHYERVVSPGIDPFFTDLSGLTLQSGVGVGPGGRLVKDEYTVGGGSTSSGAGVGVGVGVGVGVSAGMDVDNEMNQTIQHHPPPSQPPAPSNSQQTPQPFIPGMAPPNPANGEGVFSGGGVPNSANSHPKLEDSSCPQPTWIPTPHHSSTRNMHHSVVHSMSHTVGNQQQPLNPPSSGNGSGQMLSPAQAQTGESFYSTASPPQDLNQPPTAVDALTASLSGNQSSPVSPVHLQHHQNGFAVATVANPYNSGAPQWTGANTLTYTQSMQPPDHRHMHATSYWGGHGEVGGSVGGLLSNQPAPEYWCSVAYFELDTQVGETFKVSSSCPTVTVDGYVDPSGGNRFCLGALSNVHRTEQSERARLHIGKGVVLDLRGEGDVWLRCQSEHSVFVQSYYLDREAGRSPGDAVHKIYPSAYIKVFDLRQCHKQMRGQAATAQAAAAAQAAAVAGHLTHGTPITKSLSAAAGIGVDDLRRLCILRLSFVKGWGPDYPRQSIKETPCWIEVHLHRALQLLDEVLHTMPIDGPRGIE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01207364;
90% Identity
iTF_01493591;
80% Identity
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