Basic Information

Gene Symbol
-
Assembly
GCA_947095525.1
Location
OX352755.1:2358117-2361827[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.071 5.2 8.2 7.1 1 23 149 172 149 172 0.95
2 18 0.00028 0.02 15.8 0.9 1 23 181 204 181 204 0.96
3 18 0.0022 0.17 12.9 0.4 2 23 217 239 217 239 0.97
4 18 0.0018 0.13 13.2 0.8 1 23 248 271 248 271 0.96
5 18 0.0021 0.16 13.0 3.0 1 23 283 306 283 306 0.96
6 18 0.00013 0.0099 16.8 0.7 2 23 333 355 332 355 0.97
7 18 0.0013 0.096 13.7 1.2 2 23 365 387 364 387 0.96
8 18 0.091 6.8 7.8 1.8 3 20 393 410 391 412 0.91
9 18 0.0007 0.052 14.5 0.5 2 21 417 436 416 439 0.94
10 18 0.2 15 6.8 1.6 3 23 449 470 447 470 0.92
11 18 7.5e-05 0.0055 17.6 3.7 1 23 475 498 475 498 0.94
12 18 6.2e-05 0.0046 17.8 1.6 2 23 510 532 509 532 0.95
13 18 0.00047 0.034 15.1 2.9 1 23 558 581 558 582 0.94
14 18 0.22 17 6.6 0.4 2 23 588 608 587 609 0.91
15 18 0.0057 0.42 11.6 1.5 2 23 615 636 614 636 0.97
16 18 2.5 1.9e+02 3.3 2.0 3 23 644 666 642 666 0.89
17 18 0.0093 0.69 11.0 0.2 1 23 702 724 702 724 0.97
18 18 0.081 6 8.0 2.0 1 23 730 753 730 753 0.97

Sequence Information

Coding Sequence
ATGGCAGAGCCAGAACTTAAAATTAAAATAAAAATTGAAAGAAAAGATCCTACCTCATTTTTACCGGAGGAGCCTATGAGTTATGAAATTAAAAAAAAGAAGAAAAAGAAAAAAAAAATTCAAGAAGACCCATTTAAAGATATTGATGAAAATAAAACAGAAACAAAGACTACTGATAATACGAAAACTCAATTTTCGCCAGTAGCCTTAGATCCTGAAGTAAATATAAAAGTGGAAAATATTGAAGTGGAATTGGACTTTAATGATTTCACCGACAACCAAGGCCTCATGCTTGAAACTCCGCATAGCGACGACAGCCAAGAACCTGCAATTAAATACGAGAACCACAACCATGAGGCTGTTCTACTTACTTTTGAAAGTATCATCAACGAAAAGAAAATAATACCCTACCAAGAAGAATTGGATGTTACACCTAAACCGGACCACTTTTGCAAAGTCTGTCATCTAGTCTTCCAATCTACGAAAACCTTAAGAATGCATCAGAAAAGAAAACATAAAGCATTCAGAAAGTCATTTAAACATATTTGTGATTATTGTGGTATGTCTTACGAAATGAAAAACAGTTTGGTAGCTCATATTAAACGGAAACATTCACCCGGTACCATGCCTGATGATAAAGAAGAAAGGACGTGTGACATTTGTGCTCTAGTGTTTAGAGGCAATGCCCGGTTACGAATGCACATGAGACGAAAACATGGATCATTTCAGGAATCATTTAAACATGTTTGTGATGAATGCGGTCTCACTTATGATAAATATAGAAGTTTAATAGTTCATGTACAACGTAAACATTCAAATCAAACTAAGCCAGAGATCAGTCAGTGGTATAACTGTATGTTTTGTCCGAAAATGTTTACGAAAAGGGAAACTTATTCAAGACATGTTCAGAGAAAACATCAAGTATCTGATGATTTGAAGAACGAAAATGCCGAGTTTGACTTGGAAAGTTGTAAAAATGAGCAAACGGGTGAGATCACTTGTAAGGAATGTCCTCTAGTCTTTTCCTCTATAAATTTCTTAAAACTGCACATGAGAAGGAAACATAATGCATTGAAAGATAACTTTAGATTGAAGTGTAGAATTTGTAACTTGTCTTACGATAAGATTGAAAGTCTTAAACGTCACGTGAGACGGAAACATGATAAAGGATCCCATTGTGAGGTCTGTAACAAACAATTTGATACAAGAGAAATGTATTTAAACCATTCACATACAAAAGTTATAAAGGAATGTACAATTTGTGGGCTCATATTTGCCTCTCAGGGAGGTTTAGCGAAACACTTAAGGTGTACACACAAAATAGATGCACAGAAAACTATTTTCTGTAATTTATGCAATGAAGGCTTTCATGATAAACGTCAATTAAAACCGCATTTTATGAAAGTGCATTTAAAAGTTTCATATACATGCAAGTATTGCAAGAAAGTTTTTAAAGCTAAAGAAAGTTATCGCCGGCATATACTGTTCAAGCATCCTACTACCCAACACATTAGTACTCAGATGCAAAAATGTGAATATTGCAATGAAATGTTTAAAGATGAATTCGACCTTTGCAAACATATAAATTTAGCTCACGGTCAGACCGATGAGGGTTTGCGCAGTATAATGGACCTACACGTTAAAAGAGAAGATGAAGATATAAAGAATAATTTTCAGTGCACAAAGTGTCCTGAAGTTTATATTACTTGGGAACAGTTAAAGTTGCACTATGAGCAGTGTCACCATAACGTTGAACAGACACAATGTCAGATATGTGGTGAGATACTACCAGGGAATGAGTTACAAAAGCATATTAAAAGTCATCATACTGACATTGATATGCAATGCAAATATTGTGAGTTCAAAACTAACGTAAAAATTAGCTTAACTCAACATATGTTGAGACATAAGAATGCTGCAACATTACACTGTGACTACCCTAATTGTAAATACAAAACTTTTTATGAAGGTGCTATGGAGAAACATAGAAGGAAGCATGCAGATCAAGGAGTCAAACTCCAATGTACGCAATGTCCTTTCCAAACTATGAATAAGTACATACTAAAATATCATGAGGAAGCTCATGAAACGGGCGTCAAAAGGTATACATGTGACCAATGTGATTATGCAACGATTTTACCCGCCAATTTGGTTCAACATAAATATAAGCATTCTACTGAGAAACGGTTTAAATGTGACGTCTGTCCCTTTGCAACGAAGTACAACACATCATTACGCTTTCATGTTAGAAAAAAACACTGTGATCTCCCAACATTCAGCTAA
Protein Sequence
MAEPELKIKIKIERKDPTSFLPEEPMSYEIKKKKKKKKKIQEDPFKDIDENKTETKTTDNTKTQFSPVALDPEVNIKVENIEVELDFNDFTDNQGLMLETPHSDDSQEPAIKYENHNHEAVLLTFESIINEKKIIPYQEELDVTPKPDHFCKVCHLVFQSTKTLRMHQKRKHKAFRKSFKHICDYCGMSYEMKNSLVAHIKRKHSPGTMPDDKEERTCDICALVFRGNARLRMHMRRKHGSFQESFKHVCDECGLTYDKYRSLIVHVQRKHSNQTKPEISQWYNCMFCPKMFTKRETYSRHVQRKHQVSDDLKNENAEFDLESCKNEQTGEITCKECPLVFSSINFLKLHMRRKHNALKDNFRLKCRICNLSYDKIESLKRHVRRKHDKGSHCEVCNKQFDTREMYLNHSHTKVIKECTICGLIFASQGGLAKHLRCTHKIDAQKTIFCNLCNEGFHDKRQLKPHFMKVHLKVSYTCKYCKKVFKAKESYRRHILFKHPTTQHISTQMQKCEYCNEMFKDEFDLCKHINLAHGQTDEGLRSIMDLHVKREDEDIKNNFQCTKCPEVYITWEQLKLHYEQCHHNVEQTQCQICGEILPGNELQKHIKSHHTDIDMQCKYCEFKTNVKISLTQHMLRHKNAATLHCDYPNCKYKTFYEGAMEKHRRKHADQGVKLQCTQCPFQTMNKYILKYHEEAHETGVKRYTCDQCDYATILPANLVQHKYKHSTEKRFKCDVCPFATKYNTSLRFHVRKKHCDLPTFS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00932998;
90% Identity
-
80% Identity
-