Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 4.6e-05 0.0047 17.9 5.0 3 23 71 91 69 91 0.95

2 7 0.00013 0.013 16.5 0.9 1 21 95 115 95 116 0.94

3 7 1.9e-06 0.00019 22.3 1.8 1 23 139 161 139 161 0.98

4 7 0.0039 0.4 11.8 3.2 2 23 167 188 166 188 0.96

5 7 0.00018 0.018 16.0 0.5 3 21 197 215 195 219 0.91

6 7 1 1.1e+02 4.2 0.3 3 20 225 242 223 244 0.90

7 7 0.019 1.9 9.7 2.4 2 23 249 271 248 271 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	4.6e-05	0.0047	17.9	5.0	3	23	71	91	69	91	0.95
2	7	0.00013	0.013	16.5	0.9	1	21	95	115	95	116	0.94
3	7	1.9e-06	0.00019	22.3	1.8	1	23	139	161	139	161	0.98
4	7	0.0039	0.4	11.8	3.2	2	23	167	188	166	188	0.96
5	7	0.00018	0.018	16.0	0.5	3	21	197	215	195	219	0.91
6	7	1	1.1e+02	4.2	0.3	3	20	225	242	223	244	0.90
7	7	0.019	1.9	9.7	2.4	2	23	249	271	248	271	0.97

Coding Sequence: ATGGATACCGTCGATTCGATCAAACAAATGATTCTGCAACAAATAAAAccaatcaattttggagatgaGTTGAATATTGCTGCCATTTTAGGAGAAGAATCAATCGATCATACTTTGCCGGTGTCTCTGGATGAAGATCCTGCTCCTGTGGTGACTCCGGAAGAAGTACCACCACCAGCGAATCTTCTAAAACCCGTGGAGAACGTAATCTGTCACGTCTGTTCGAAATCTTTTACAAAttctcgtaattttaaaaaacacttcaCGAAGCACACCGGTCAATTTTCTTGCCGCGGatgtaaaaaaGTTTTTGCAAGGAAAGATACCCAACAGAAACACATTACAAGGTGTAAAAGTATCCAtggtaaaactaaaaaacggaaaaatacGTCCCAAGATGAAGAAGGTAAAAAGTATTATTGTGATAAATGCAGTAAGAGTTTTACTCGAAGAGAAAACTACGATCAACATATCATGATTCATGATGGAGTTCAAGTGGTTTGTAActtttgtcagaaaaaattgagtagtttcaaatcatttcaaaGACACAGAAAACTTCATGAAACCCCTCAACAAAAAATCGCTTGCCAAGAGTGTCCTTCTgaattttcattgaaatcaaatcttcaaaggcacatcaaatttcaaaagcataaacataaaataatttgtgatAAATGTAACGCTACCGTTAAGACAGAccatattttgcaaaaacatcAATCGCAAGATAGCATCAGCACGTGTACATTGTGCTCTCAATCATATTGTTTGGAACTAGATCTTCGAAGTCATTTGAGAAAAGATCACTCAAATTTGTGGTTTAAATGTAAAGAGTGTACGAGTAGACCTTTTATGACTAGAGGTATGAAATATTTGCAAGATCACgcgaagaaaattcattctGTTCATCTGGAAAtcaataattgttttgaagaaggatggtttgttgttttttcaaattaa
Protein Sequence: MDTVDSIKQMILQQIKPINFGDELNIAAILGEESIDHTLPVSLDEDPAPVVTPEEVPPPANLLKPVENVICHVCSKSFTNSRNFKKHFTKHTGQFSCRGCKKVFARKDTQQKHITRCKSIHGKTKKRKNTSQDEEGKKYYCDKCSKSFTRRENYDQHIMIHDGVQVVCNFCQKKLSSFKSFQRHRKLHETPQQKIACQECPSEFSLKSNLQRHIKFQKHKHKIICDKCNATVKTDHILQKHQSQDSISTCTLCSQSYCLELDLRSHLRKDHSNLWFKCKECTSRPFMTRGMKYLQDHAKKIHSVHLEINNCFEEGWFVVFSN

Sequence clustering based on sequence similarity using MMseqs2