Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00023 0.024 15.7 2.0 1 23 72 94 72 94 0.97

2 6 5.1e-07 5.2e-05 24.1 3.2 1 23 100 122 100 122 0.98

3 6 3.9e-06 0.0004 21.3 1.2 1 23 128 150 128 150 0.98

4 6 0.00068 0.069 14.2 0.3 1 20 156 175 156 178 0.90

5 6 2.1e-05 0.0022 18.9 0.8 2 23 185 206 184 206 0.97

6 6 0.00074 0.076 14.1 0.3 6 23 216 234 212 234 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00023	0.024	15.7	2.0	1	23	72	94	72	94	0.97
2	6	5.1e-07	5.2e-05	24.1	3.2	1	23	100	122	100	122	0.98
3	6	3.9e-06	0.0004	21.3	1.2	1	23	128	150	128	150	0.98
4	6	0.00068	0.069	14.2	0.3	1	20	156	175	156	178	0.90
5	6	2.1e-05	0.0022	18.9	0.8	2	23	185	206	184	206	0.97
6	6	0.00074	0.076	14.1	0.3	6	23	216	234	212	234	0.95

Coding Sequence: ATGCCTATTGGATTCGCCTCATTGAATACATATCGttctatggaatttttaacccaACATTTAGACCGTCAATACGAAATTAAACCCGAAGTACCATTATTTCATATAGACGACAAATCTACTATGACTGATAAAACTATGCAGAGTAATATACCGGCTGCGCCTGCTACTGTAGCTAAAAGCGTGAAAAAGACCAGCAACGAGTACAAAACTCATTCGTGTTACGTATGTGGAAAAGTCCTATCCTCTACGTCTTCTTATTACGTTCACATGAAACAACATTCGGGACATAAACCATATCATTGCCCTATGTGTGACGTTAGTTTCTGCCGAAAACCTTACTTAGAGGTCCACATGAGAACACATACCGGTGAACGACCATTTCAATGTGCAGTTTGTTTGAAGCGATTTACTCAAAAGAGTAGTTTGAATATTCATAAACGAGCTCATACCGGAGAAAGGCCTTATTCTTGCGACAtctgtgataaaaaattcgcagTCAAGAGTTACGTTGATGCCCACAGGTGGACTCACATATTCGAGAAGCCGCTTTCctgtgaaaaatgtaaaatacctTTCAACTCGAGAAGTCAATACGTGTTGCATATGCGATCTCATTCAACATCATTAGCTTATGAATGCCCGTGTGGTCGTACTTTTACCAAGGATAGTTACTTAATCAGACACCAAATTAAAGTGCACGGAAATGGAGACAACCATTCAATTCCTGATCTTAGTTTTCATCAGGTGTATGTAACAGAAGAACCTTTAGTTAAAGAAGAGAAGTACGACGTTCATTCACCGACCAGCGTCAGAAATGTTGGAACGCCTCTGCCTCTACCCGAGATAAAGGAAGAGAAACCTCGGATTATTCGCAAGCTGGAAAACGCCTTAAGTTTGACAGCTTCGATGCCTTCTATTTCGCCGGTGATCCGAGAAAGTATCGAATCCTACGTTCAAAGTTCTTCGAATCAGTTAGCTAAATTATAA
Protein Sequence: MPIGFASLNTYRSMEFLTQHLDRQYEIKPEVPLFHIDDKSTMTDKTMQSNIPAAPATVAKSVKKTSNEYKTHSCYVCGKVLSSTSSYYVHMKQHSGHKPYHCPMCDVSFCRKPYLEVHMRTHTGERPFQCAVCLKRFTQKSSLNIHKRAHTGERPYSCDICDKKFAVKSYVDAHRWTHIFEKPLSCEKCKIPFNSRSQYVLHMRSHSTSLAYECPCGRTFTKDSYLIRHQIKVHGNGDNHSIPDLSFHQVYVTEEPLVKEEKYDVHSPTSVRNVGTPLPLPEIKEEKPRIIRKLENALSLTASMPSISPVIRESIESYVQSSSNQLAKL

Sequence clustering based on sequence similarity using MMseqs2