Basic Information

Gene Symbol
-
Assembly
GCA_000599845.3
Location
NW:2258810-2262300[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00012 0.002 18.0 0.3 1 23 30 53 30 53 0.97
2 12 1.5e-05 0.00025 20.8 3.7 1 23 59 82 59 82 0.97
3 12 0.0031 0.051 13.6 1.3 1 23 88 111 88 111 0.95
4 12 1.4e-05 0.00022 21.0 2.7 1 23 117 140 117 140 0.96
5 12 0.00052 0.0084 16.0 0.8 1 23 146 169 146 169 0.93
6 12 3.9e-05 0.00063 19.6 1.2 1 23 175 198 175 198 0.97
7 12 7.1e-05 0.0012 18.7 4.1 1 23 204 227 204 227 0.98
8 12 2.6e-05 0.00042 20.1 2.1 1 23 233 256 233 256 0.96
9 12 0.019 0.31 11.1 0.2 1 16 262 277 262 279 0.91
10 12 0.41 6.7 6.9 0.5 7 23 297 314 297 314 0.95
11 12 0.00033 0.0054 16.6 1.6 1 23 320 343 320 343 0.96
12 12 9.3e-05 0.0015 18.4 0.9 3 23 351 372 349 372 0.98

Sequence Information

Coding Sequence
atggataaaagtgagaaaaaattcaacgaagttgtctttaaaaaaaattcaagtgaacacgacTTTGTTGTTTTAGACTACAAAAAATACgtgtgtgatatttgccagaaggcatttacactagaatcaagcatgacaacgcaccgagacacaattcacaatgaacaaaaaaagtacgaatgtgaccagtgcgagaagaaatttaagttccgaagtcatttgagtagacaccaaatatcagaacacagaGGCCGccaagattttgcatgcgaccagtgtgaaaagaaatttctgaaaaaatcgagtttattgacgcaccaaaaattaatacataaagATCGTGAACATTTCCCGTGTAACAAGTGTGATaggaagtttgaaaataaatcaactttacttaaacacaaaaaaatattccacgaagtttttaaagactacttatgtgaaaagtgcgccaagagattttcAAGTAAGCAGAGTTTACTCACACACGTAAAGGAAGTCCATGAGAGTTGCAAAAATttcgtatgcgacaagtgcgagatgaaatttagaggaaaatcgaaattaatcagacaccaaacgacagtccatgaaggttgcaaagattacacatgcgacaaatgtgaaaggaaatttgagaaaaaatcacatttgtttAACCACGAAAACACAGTCCATGAgtgtcgcaaagatttcgcatgtgataattgcgagaagaagtttgggtACAAATCGCATTTGCGCGTCCATCAAAAttcaatccatgaaggtcgcaaagattacgcgtgtggtgaatgcgagaaaaaatttacacgaaaacCGAGTTTACTTTTGAATCGAAAAACGATACACGAAGGCCGTAAAGATTTCACAAGCGACAAgggcgacaagaaatttggacataaatgtaattttctcgtacacataaaaacagtgcacgaaggtcgcaaagatttcgcatgcgacagatgtgaaaaaaaatttggacaaatatCGAATTTGATCCGCCACCATTatacagtccatgaaggtagTAGAGAATTTGGTTGTgacaattgtgagaagaaatttggactgaaATCAGATTTGTCTAAGCATCAAAGAACAGTGCATGAAGTTCCCAGTAAACTGTGGAGATTTTAG
Protein Sequence
MDKSEKKFNEVVFKKNSSEHDFVVLDYKKYVCDICQKAFTLESSMTTHRDTIHNEQKKYECDQCEKKFKFRSHLSRHQISEHRGRQDFACDQCEKKFLKKSSLLTHQKLIHKDREHFPCNKCDRKFENKSTLLKHKKIFHEVFKDYLCEKCAKRFSSKQSLLTHVKEVHESCKNFVCDKCEMKFRGKSKLIRHQTTVHEGCKDYTCDKCERKFEKKSHLFNHENTVHECRKDFACDNCEKKFGYKSHLRVHQNSIHEGRKDYACGECEKKFTRKPSLLLNRKTIHEGRKDFTSDKGDKKFGHKCNFLVHIKTVHEGRKDFACDRCEKKFGQISNLIRHHYTVHEGSREFGCDNCEKKFGLKSDLSKHQRTVHEVPSKLWRF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-