Basic Information

Gene Symbol
-
Assembly
GCA_000599845.3
Location
NW:1733075-1735217[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.069 1.1 9.3 0.0 1 23 30 53 30 53 0.95
2 14 0.0031 0.051 13.5 5.2 1 23 59 82 59 82 0.96
3 14 4.6e-05 0.00076 19.3 1.4 1 23 88 111 88 111 0.95
4 14 0.00024 0.0039 17.1 3.0 1 23 117 140 117 140 0.95
5 14 7.9e-05 0.0013 18.6 0.7 1 23 146 169 146 169 0.96
6 14 3.8e-05 0.00062 19.6 1.9 1 23 197 220 197 220 0.98
7 14 7.6e-06 0.00012 21.8 1.2 1 23 226 249 226 249 0.97
8 14 4.9e-06 8e-05 22.4 0.3 1 23 255 278 255 278 0.97
9 14 0.0023 0.037 14.0 1.6 1 23 284 307 284 307 0.97
10 14 2.5e-05 0.0004 20.2 1.2 3 23 315 336 313 336 0.96
11 14 1.8e-05 0.00029 20.6 0.3 1 23 342 365 342 365 0.98
12 14 3.4e-06 5.5e-05 22.9 0.5 1 23 371 394 371 394 0.97
13 14 3.3e-05 0.00054 19.8 0.8 1 23 400 423 400 423 0.98
14 14 1.4e-06 2.2e-05 24.1 1.0 1 23 429 452 429 452 0.97

Sequence Information

Coding Sequence
atggataaaagtgagaacaAAATCGAAGAAGGTGtcttggaaaataattcaagtgaacacgacgatgttgtttcagacgataaaaaatacgtttgtgatatttgtcaggaggcatttgcACTAGAGTTAAGTATGATAGCACACCGTGACACGATTCACAATGAACGAAAAGAGtacgcttgtgacaagtgcgaaaaaaaatttgagttccggtgtcatttgagtagacaccaaatatcagaacacaaaagccgtaatgattttgcatgcgaccagtgtgagaagaaatttgtgaaaaaatcgagtttatttacgcaccaaaaattggcACATAAAAATCTCGAAGATTacttatgcaacaagtgcgagagaaaatttgaaaataaatcgactttactcaagcacaaaaagatattccacgaagttttaaaagattacttatgtgaaaagtgcgccaagagatttgtaaataaaaagactTTGCTtgtgcacataaaaacagtccacgaaggtcgtaaaaatttgacattgagacaaaaatcacatttgctcttccaccagaagatagtccacgaaggtccgaaagatttcacatgtgacaagtgcgagaggaaatttggagaaaaatcgaaactgACTAGACACCGAAGGATAATCCACGGGAATCATAAAGATcacgaatgcgacaagtgcgagaaaaaattcggacaaaaatcagatttgatcATCCACCAacaaacagtccatgagggtcgcaaagactacgcatgcgacaagtgcgagaaaaaattcggacaaaaatcagatttgatcATCCACCAacaaacagtccatgagggtcgcaaagatttctcatgcgacaagtgcgagaagataTTTGGGTTAAAATGGACTTTGCATTTGCATCAAAGGTCAGTCCACGaacgtcgcaaagattatggatgcgacaaatgcgagaagaaattcgggaATCGAAGCAATTTAAAACAACATCAAAAACTAGTCCACGacggtcgtaaagatttcgttTGCGATGAGTGCAAGAAGATATTTGGGTtgaaatcgagtttgcttGTGCATCAAAGGACAATCCACgagggtcacaaagattacgcatgcgacaagtgcgagaaagaatttgcacaaaaaatgcaattaatcaggcaccaaaagacggtCCACGATGGACAGAGAGATTAcacttgcgacaagtgtgaaaagaaatttgcagAGCGAGGAAATATGATCactcaccaaaaaacagttcacgaaggtcgtaaagattatgcatgcgacaaatgtgagaagaaatttacacaaaaatcgaatttaatcTACCACCAagagacagtacacgaaagtcgcaaGGATAATTCATGCGGCGCtcgtgaaaagaaatttggtaaaaaattcatttga
Protein Sequence
MDKSENKIEEGVLENNSSEHDDVVSDDKKYVCDICQEAFALELSMIAHRDTIHNERKEYACDKCEKKFEFRCHLSRHQISEHKSRNDFACDQCEKKFVKKSSLFTHQKLAHKNLEDYLCNKCERKFENKSTLLKHKKIFHEVLKDYLCEKCAKRFVNKKTLLVHIKTVHEGRKNLTLRQKSHLLFHQKIVHEGPKDFTCDKCERKFGEKSKLTRHRRIIHGNHKDHECDKCEKKFGQKSDLIIHQQTVHEGRKDYACDKCEKKFGQKSDLIIHQQTVHEGRKDFSCDKCEKIFGLKWTLHLHQRSVHERRKDYGCDKCEKKFGNRSNLKQHQKLVHDGRKDFVCDECKKIFGLKSSLLVHQRTIHEGHKDYACDKCEKEFAQKMQLIRHQKTVHDGQRDYTCDKCEKKFAERGNMITHQKTVHEGRKDYACDKCEKKFTQKSNLIYHQETVHESRKDNSCGAREKKFGKKFI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-