Basic Information

Gene Symbol
-
Assembly
GCA_000599845.3
Location
NW:65177-71298[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0083 0.14 12.2 0.2 1 23 30 53 30 53 0.97
2 16 9.1e-05 0.0015 18.4 3.2 1 23 59 82 59 82 0.94
3 16 0.0012 0.019 14.9 0.9 1 23 88 111 88 111 0.95
4 16 2.6e-05 0.00042 20.1 5.0 1 23 114 137 114 137 0.97
5 16 0.0043 0.07 13.1 0.2 1 23 143 166 143 166 0.93
6 16 1.1e-05 0.00017 21.3 0.7 1 23 197 220 197 220 0.97
7 16 6.3 1e+02 3.2 0.3 8 23 233 249 226 249 0.88
8 16 5.4e-05 0.00087 19.1 4.4 1 23 255 278 255 278 0.97
9 16 2.9e-05 0.00047 20.0 1.2 1 23 284 307 284 307 0.97
10 16 0.00034 0.0055 16.6 1.2 1 23 313 336 313 336 0.98
11 16 6.6e-06 0.00011 22.0 4.8 1 23 342 365 342 365 0.98
12 16 7.1e-05 0.0012 18.7 1.6 1 23 371 394 371 394 0.97
13 16 7.5e-05 0.0012 18.6 1.2 1 23 400 423 400 423 0.98
14 16 0.00015 0.0025 17.7 0.5 1 23 429 452 429 452 0.98
15 16 6e-05 0.00098 19.0 0.8 1 23 458 481 458 481 0.97
16 16 2.6e-07 4.2e-06 26.4 0.7 1 23 487 510 487 510 0.97

Sequence Information

Coding Sequence
ATGGATAGAACTGATAAGAAACTCGAAAAAGATgtctcgaaaaattattcaaatgaaaatgacattgttgtttcaaacgacaaacaatacatttgtgatatttgtgaaGAGGCATTTCCACTGGAATCAAGTATGATGACACACCGACACACAATTCACAATTTAGAAAAAACTTActtatgtgacaagtgcgagaagaaatttgagttccgaagtcactTGAAtcgacaccaaatatcagaacacaaaggccgtaataattttgcatgtgaccaatgtgagaagaaatttgtgaaaaaattgagtttacttacgcaccaaaaattagtacataaagaTTTCACGTGTAAAAAGTGCGataggaaatttgaaaataaatcaagtttattcaagcacaaaaaaatattccacgaagtttacaaaaattatttatgtgaaatgtgcgccaagagatttgatactaaacccagtttgctcttgcacttAAAGGCAGTTCACGAGGTTCCAAAAGATTTCACCTACGATGAGAGCAAGAAGAAATTAGGGGATCAAagcaatttaattaaaaaccaaaaaataactcatgatttcgcatgcaacaagtgcgggGAGAAATTCGGTCAAAACTCGCAATTGCTCtatcaccaaaagacagtacacacAGGTccaaaagattacgcatgtgacaagcgtgaaaaaaaatttgcacaaaaaacgAGTTTTCTCTACCATCAAACGTCAGTACACGAAAGTCACAAAGGTTacgcatgcgaaaaatgcgaaaaaaaatgtagactTAAGTCTAATTTGTTcaaacaccaaaggacagtacacgaacgTCGCAaggattttgcatgtgataagtgtgagaagaaatttataagCAATTCAGATGTATttaagcaccaaaagacagtccacgaaggtcgcaaagattacgtatgtgacgaatgcaagaaaaaatttggacttaaacaaaatttgctaatgcacaaaaaaacagtacacgaaggtcgcaaagactacaaatgtgaaaaatgcgagaaaaaatttggacaaaaatcgcatttgcttcGACACACAAAAACATTACACGATGGGTGCAAAGATTTTAGATGCGAcgaatgtgagaaaaaatttgcacgaaaatCCTATATGCTTTTGCACCGAAAAATAatgcacgaaggtcgcagagatttcacatgtgataagtgtgaacaaaaatttggagaaaaatcgaaattgatctCTCACCAGAggactgtacacgaaggtcgcaaagattatacatgcgatcaatgtgaaaaaaaatttggggctCAAAGCAAATTAATAACACACCAAAAGATCgtgcacgaaggtcacaaagattacgcgtgcgacaagtgcgagaaaaaatttggagaaaagagTTATTTGCTGAAAcatcaaaagatagtacacgaaggtcgcaaagattttgcatgtgacaagtgcggaaaaaattttggacaaaaatcgaatttgctcagacaccaaatgACAGTACATAAAGGACGCAAAGTTTGA
Protein Sequence
MDRTDKKLEKDVSKNYSNENDIVVSNDKQYICDICEEAFPLESSMMTHRHTIHNLEKTYLCDKCEKKFEFRSHLNRHQISEHKGRNNFACDQCEKKFVKKLSLLTHQKLVHKDFTCKKCDRKFENKSSLFKHKKIFHEVYKNYLCEMCAKRFDTKPSLLLHLKAVHEVPKDFTYDESKKKLGDQSNLIKNQKITHDFACNKCGEKFGQNSQLLYHQKTVHTGPKDYACDKREKKFAQKTSFLYHQTSVHESHKGYACEKCEKKCRLKSNLFKHQRTVHERRKDFACDKCEKKFISNSDVFKHQKTVHEGRKDYVCDECKKKFGLKQNLLMHKKTVHEGRKDYKCEKCEKKFGQKSHLLRHTKTLHDGCKDFRCDECEKKFARKSYMLLHRKIMHEGRRDFTCDKCEQKFGEKSKLISHQRTVHEGRKDYTCDQCEKKFGAQSKLITHQKIVHEGHKDYACDKCEKKFGEKSYLLKHQKIVHEGRKDFACDKCGKNFGQKSNLLRHQMTVHKGRKV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-