Basic Information

Gene Symbol
ZFY
Assembly
GCA_902732785.1
Location
CACVKI010145237.1:149979-154124[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.11 8.9 7.1 0.9 1 22 164 185 164 185 0.94
2 20 0.015 1.2 9.8 1.3 1 23 193 215 193 215 0.98
3 20 3.6 3e+02 2.3 0.3 3 12 219 228 217 238 0.82
4 20 0.16 13 6.5 3.3 2 23 246 267 245 267 0.96
5 20 0.0053 0.45 11.2 0.1 2 20 364 382 363 384 0.94
6 20 0.18 16 6.3 4.9 2 23 392 413 391 413 0.96
7 20 0.00013 0.011 16.2 0.3 3 20 501 518 500 520 0.94
8 20 6.3 5.3e+02 1.5 6.3 1 19 527 545 527 549 0.94
9 20 0.018 1.5 9.5 0.3 2 21 605 624 604 625 0.91
10 20 1.4 1.2e+02 3.6 0.2 2 21 635 654 635 655 0.88
11 20 0.00065 0.055 14.1 2.1 1 23 662 684 662 684 0.98
12 20 0.68 57 4.6 0.2 2 20 740 758 739 760 0.90
13 20 0.03 2.5 8.8 0.2 3 23 774 794 772 794 0.96
14 20 0.89 75 4.2 0.5 2 13 817 828 817 830 0.88
15 20 0.03 2.5 8.8 1.2 2 22 846 866 845 866 0.94
16 20 0.0011 0.091 13.4 2.3 1 23 874 897 874 897 0.93
17 20 1.4e-05 0.0012 19.3 1.6 1 21 906 926 906 927 0.96
18 20 0.08 6.7 7.5 1.8 1 23 934 956 934 956 0.96
19 20 0.009 0.76 10.5 0.3 1 23 1019 1041 1019 1041 0.97
20 20 0.0011 0.095 13.3 0.3 3 21 1049 1067 1047 1068 0.93

Sequence Information

Coding Sequence
ATGCCTATGTTGAAGATTGCTTATAAAAGAGGAATTCAGTCAAATGTAAATACAGCTAATATTTCACATGAGCaaataaaaactcaaaatgaaaaacctatttcaaaaaagaaaatatctaAAGATTTCTCAAGatcaatttcaaatgaaattaaaaaccaTTCCGTTGACAATGATATAGAAGTATTGAGTTTAGAGGATACAGAACCATCTGAAATACAAGAAAGATGTGATAAcactcaaaaaaaatatgatgaaaGCTTAAATGATTTAAAGgatgaaaattcatcattaAATCCAGAACTTGCTGATAATGTTCAAGAAGATCTTGACTCTAGCATAAAAGAAGagattaaacaaaaaagacAACTTTTTTATCAAGTGATGGCTTCGtctattattcttttttgttcCAAATGTCAAGAGACAAGGGAAGATCCTGTTAATCGTAATAAATCTTTCTGCAGAAAATGCAAAGCATGGTTATCTTACCAAtgcaaaaaatgtgaaaaactaTACACAAAATATGAAAGTATAGTCTACCATGTACGAACTTCATGCAATCCGCAAGAATCATTTAAGTGTTCATCATGTACATATACTACTCCTATTGAAGGTCATCTGATCAAGCATTTAAAAATCCACCGAGTCAACTGCACTGTATGTAAGGAAAGTTTCGAAAATGGTTCAATATTTgatgaacataaaaaaacttGTAACATAGTTGAAACTTTATCTTGTGAACATTGCACTTTTAAAACACCATTTAAAAGGGCTTTCAGAAATCATATTTTGCGGCACGTAGAGCAGATTaaagtaaaaagagaaaaaagggtTAAAAATAAAGCAGTTTTGGACTTACCACCTCCTTCAGAATCAAATGAATTTAgtttatcattgttattttatgCTATTTGTCAAAGTTGTGAAGATACAAAAgatgaaaacaataaattcaaaaaacaatgtaataaatgttttacaaaattaaagttGCATTGTCTAAAATGTACAGCAGAGTGTGAATCGCTTGATGATATTGTTTGTCATTTAAAAGAAGAATGTGGTGTTCCTGAAGTGGTGGTAGATCAATGCTTGAATTGtggaaaaatcttgaaaaactATGCAACATTGAAAAGACACTATGAATGGTGCGCCGTTGCAGCAACTTTAACGTGCACATTATGCCCTTATAAAACTAAGTATGAAAAGTGTTTACTTCGTCATATACACAGTCATACAAAAATGGatgaacgaaaaattaaaattcaaaaaaatgtatctgaAAAAAGCAGTAgtGTTCTGCTGTTGTGCAAACGTTATTGTCCATCTTGTAATGAATCTGTTGAAAATTCTcctttcaaaaatgtaatgtGGTGTACAAAATGTCAATCTCATTACATATGGCAATGTTCAAAGTGCGAAGAAAAAACTGACAAATACGCTAAAATGGCTTATCATGTGAAGAATTACTGTTTTAGTAGTAATTCTCCCAAAGATTGCTCAAAATGTGGTAAAAAATTCAGGAACCCAGTAACTTTAGGAAAACATATGACGTATTGTGGAAAAGCCGCTCATTACCAATGTGAGCAATGTCCATTCAAAACTAAATTTCGACAAAGTTTCAAAAATCACAGCCAATGTCATATGCAAAAAAGTGTGTCAATGGATGAAAGTTTCAATGATGGTAGAGcaaatacatCTCTTTTGCAATTGTTCCTTCGTTACTGTAGTACTTGTAATGAAACAGTCGAAAATAGCCCATtcaaaaatgagaaattttgtgaaaaatgtaaaactgAATATGTTTTGCAATGTGCCAAATGCGATAAAAGATTTCCGACTTATCGAAGTATGGTTTATCATGCAAGAAATACCTGCGAAAAAACTCAAACAATGAATGTCTGTCCGAAATGCGGTGAAGCTATAGCAAAACATGGACGGTACAGTAGACATGTCAAATACTGTGGCactaattttacttttaactGCAATGACTGCTTTTATCaaactaataaaaaagaaaatttgagatCTCATATATTAACACATATGAATAAGCAAATAAACGTCGACCAATCAGATGGCAATACTGAAGAtgACTATAAATCATGGAACAAATTTAATCGCTACTGTCCACAATGCAACACATTCACTCCTAACAATGCATTTAAAAACGAAAAGTATTGTGAAGTGTGTAAAACGCAGTATATCTTACAATGTTTAAAATGTGACAAACAATCGATGAACCAAAGTTCTATGGTTTACCACGTTACAAGCAGTTGTAAGCACTATTTGGAGCTAAAACCTAGCTTATTCTGCGATATTTGTGATTTTGAAACTAAAGTCCCGTTAGCTTTGGAGAAACATAGAAAAAGTCATGAAAAAGGAACAGTTATGCGGACAAGAAACCCAAATGCAGAAAGTCCACgaattcatttcaaaagaTATTGCGAAAAATGTGATACTACTTTCATTAATTCTGCTTTTaaagatgataaaaattgtaaacaatgCAAGACTGAAATGTTGCTCATGTGCaataattgtaacaaaaaaaccaaaaaatataGTCAGATGGTTTACCACATAAAAACATATTGTAATATGGTTCAGATTTATCAATGTACTGAATGTGATTACAGTACCAAGAATTCAGATGTTTTGCGTCATCATGTCTTGTTTAGACATACTTATATCGATCCGGCAGACTATCATAAATGTCCTGATTGTACCAAACCATTTAAAACACTTGatcttatgaaaaaacatatgAAATATTGCAGTATTCAGCCTACATTTTCTTGCGACCAGTGTCCTTTCAAgagtaaatacaaaaaaacaataaccAGACATATAACAGCACATTCAAGTGGTggtaattttagaaaaaataacccAGCAAGAACACGATTCTCGGTCAAAACTAAGCGAAAACGAAGTGCTCTTCAAAgCATGAAAAGTTATGTTAAGGCTACTTGCCTAAGGTGTGAAAAACAGCGATTTTTGATGCAGGGTCGTACCAAATGTCATCTTTGCAAATCTAGTTTGCAGTTCACATGTAAAGTGTGTAATTTAGAAAGCTCTTCTCTTGTAACTTTACGAGATCACGTGAAAGAACACATGAACTCACCTGTTCAACATTGTCCAGGTTGTAATAAATCTTTTGcaatcaacaaaaattttgaagatcATCAGTTAATATGCCAGCAGAGtcctaaaaatttaattgattcaaaaataaaaataaaagaTGAACCCGTGGATGAAGAAGTTTAA
Protein Sequence
MPMLKIAYKRGIQSNVNTANISHEQIKTQNEKPISKKKISKDFSRSISNEIKNHSVDNDIEVLSLEDTEPSEIQERCDNTQKKYDESLNDLKDENSSLNPELADNVQEDLDSSIKEEIKQKRQLFYQVMASSIILFCSKCQETREDPVNRNKSFCRKCKAWLSYQCKKCEKLYTKYESIVYHVRTSCNPQESFKCSSCTYTTPIEGHLIKHLKIHRVNCTVCKESFENGSIFDEHKKTCNIVETLSCEHCTFKTPFKRAFRNHILRHVEQIKVKREKRVKNKAVLDLPPPSESNEFSLSLLFYAICQSCEDTKDENNKFKKQCNKCFTKLKLHCLKCTAECESLDDIVCHLKEECGVPEVVVDQCLNCGKILKNYATLKRHYEWCAVAATLTCTLCPYKTKYEKCLLRHIHSHTKMDERKIKIQKNVSEKSSSVLLLCKRYCPSCNESVENSPFKNVMWCTKCQSHYIWQCSKCEEKTDKYAKMAYHVKNYCFSSNSPKDCSKCGKKFRNPVTLGKHMTYCGKAAHYQCEQCPFKTKFRQSFKNHSQCHMQKSVSMDESFNDGRANTSLLQLFLRYCSTCNETVENSPFKNEKFCEKCKTEYVLQCAKCDKRFPTYRSMVYHARNTCEKTQTMNVCPKCGEAIAKHGRYSRHVKYCGTNFTFNCNDCFYQTNKKENLRSHILTHMNKQINVDQSDGNTEDDYKSWNKFNRYCPQCNTFTPNNAFKNEKYCEVCKTQYILQCLKCDKQSMNQSSMVYHVTSSCKHYLELKPSLFCDICDFETKVPLALEKHRKSHEKGTVMRTRNPNAESPRIHFKRYCEKCDTTFINSAFKDDKNCKQCKTEMLLMCNNCNKKTKKYSQMVYHIKTYCNMVQIYQCTECDYSTKNSDVLRHHVLFRHTYIDPADYHKCPDCTKPFKTLDLMKKHMKYCSIQPTFSCDQCPFKSKYKKTITRHITAHSSGGNFRKNNPARTRFSVKTKRKRSALQSMKSYVKATCLRCEKQRFLMQGRTKCHLCKSSLQFTCKVCNLESSSLVTLRDHVKEHMNSPVQHCPGCNKSFAINKNFEDHQLICQQSPKNLIDSKIKIKDEPVDEEV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01485750;
90% Identity
iTF_01485750; iTF_01483421;
80% Identity
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