Tden002657.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Trichogramma dendrolimi
Gene Symbol
lz
Assembly
GCA_034770305.1
Location
JAPMIB010000004.1:2941170-2960850[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.36 1.9e+03 -0.8 1.1 56 79 131 154 79 163 0.82
2 3 4e-73 2.1e-69 231.8 0.0 3 129 202 328 200 328 0.98
3 3 2.4 1.3e+04 -3.5 1.2 57 77 499 519 492 525 0.76

Sequence Information

Coding Sequence
ATGGATATATTCAGCCGGTGCAACGGCGCTGGCCTTGTCGGTGGTGTAGCTGCTGCGGTGCCGTCGCATCACAAtcaccatcaccatcatcatcatcatcacaacAACCACCACAATCCCCACCATCACAGCAGCCATCATCTGAATCATCACAGTCATCATCAAGCTCAACCTCACCAGGCCCTCGGtcatcaacagcagcatcagcagcatcaaAGCAACCACATAAGCAGCAACGTCGTCGCCTCGAGCCATCCGCCGTTGCGCTCGTCGTCCCAGTCCCAGTCCGCCTCGGCCTCGTCGTCTGCAGCAGCGAACAGCGTCGGCAGCAACCTGGCAGTCGGCGAGCACTCGTCGGTGACCGCTGGCAGGTCGACCAGCGGCaccaataacaacaacaacaacaacaacaataacaacaataacaacaacacgAGCAGTGTCACGAAGAACCAAGTGGTGGCCGACTCGTCTTCGGCCAAGATGCAGCTGACCGGAGCGTCGGCGCCGGGTAGCGCCGCGTCGCCCGAGAGCGGCGTCTCGCCGCTGGCCGACGCCTACACGAAAATGACCAGCGACATTTTCGCGGAGAAGACGCTGGGCGACTACATGAGCGAGCATCCGGGCGAGCTCGTCAAAACGGGCTCGCCTCATCTGGTGTGCACGGTCCTGCCGACGCACTGGAGATCGAACAAAACGTTACCCATGGCCTTCAAGGTGGTGGCACTGGGCGAGGTCGGCGACGGCACTCTGGTCACGGTGCGAGCGGGCAACGACGAGAACTGCTGCGCCGAGTTGAGGAATTCCACGGCGTTGATGAAGAATCAGGTGGCGAAATTCAACGATCTGAGGTTCGTCGGCAGAAGCGGTCGAGGTAAGAGCTTTACGTTAACGATAACGGTGTCTACCTCGCCACCGCAGGTCGCCACGTACGCCAAAGCCATCAAAGTGACGGTGGACGGGCCGCGCGAGCCCCGATCCAAGACCATGCTGCCTTTTTtagggcagcagcagcctttCCACGCGTTCGCCTTTGCCTCGCAGCGAGGCGGGCCGTTCTTCGCCTCGCCGCTGGTCGATCCGCTCCAGCCGCTGCCGAGTCCGCTGCAGTCGCTGCCGAATCCGCTCCAGCCGAGGGATCCTCTGTCGTCCTTTCGCCACGCCATGCCTGGCAATTGTCAAAACATGTCTCAATTCGGCCTGCCGGCGAGTAACTCCTGGAGCTACGGCAGCACGGCCGGCTACGCGGGCTACCTGCCGGGGCCGCTGTCCTCGTGCGCGGCCCAGACGCCGTTCGCGCCACCGGCCCCGCCACCGCCGCCCTCGGCCGCGCCGTCCGCCTCCTCGACGACCGCCGTAGCAGGCGTAGGCACGTCCGTCAGCGGCGGCAACTCGGTGtcggctgcggctgcggccgccgccgccgcgttcGGAGCCGCGGCCGTAGCGGCTGGAGCCAGCAGCGTCGTGCCCACGGCGCCCGACTCCACGGCCGGTGGCAACAACCCCAACAACAGCGCCAACAACGccaacaacaataacagcgTGGCCAACCAGGCGCCCGATGCTTTCTCCACGGTCTCGTCCATTCCAGACACAACGACGCCGGGCGGCAACCAGGCGGACCCGCTCGATCACCTGTCGAGCCTGATGTcgagcggtggcggcggctcgACGCAAAGGTACCAGGGCTACGTCTCGCCGCGCTCCCTGTCCACGGACTCGAGCACGACCGGCGAGTCGCCGGTGCACGAGGGCGTCCAGGACCAGGCGTTCGTCGGCCAGAACTGCTCCTCCGcgggtggcggcggcggtggtggtggaggCGGCGGCAATTACTTCCCCACGCCCAGCGTCTTCCCGACGATACTCTACTCGCAGCTCTACAACAATCAGTTTCAAACGGGCACCGACAGTTccgatcagcagcagcaacagcagcaacagcagcagcagcatcatcaacGGGGCTTGACCGACGTAACGGGCTGCAGCGTCGTGCGCGTACCCGACGAGGTAATACGGCCCGACAACAACGTCTGGCGGCCCTACTGA
Protein Sequence
MDIFSRCNGAGLVGGVAAAVPSHHNHHHHHHHHHNNHHNPHHHSSHHLNHHSHHQAQPHQALGHQQQHQQHQSNHISSNVVASSHPPLRSSSQSQSASASSSAAANSVGSNLAVGEHSSVTAGRSTSGTNNNNNNNNNNNNNNNTSSVTKNQVVADSSSAKMQLTGASAPGSAASPESGVSPLADAYTKMTSDIFAEKTLGDYMSEHPGELVKTGSPHLVCTVLPTHWRSNKTLPMAFKVVALGEVGDGTLVTVRAGNDENCCAELRNSTALMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTSPPQVATYAKAIKVTVDGPREPRSKTMLPFLGQQQPFHAFAFASQRGGPFFASPLVDPLQPLPSPLQSLPNPLQPRDPLSSFRHAMPGNCQNMSQFGLPASNSWSYGSTAGYAGYLPGPLSSCAAQTPFAPPAPPPPPSAAPSASSTTAVAGVGTSVSGGNSVSAAAAAAAAAFGAAAVAAGASSVVPTAPDSTAGGNNPNNSANNANNNNSVANQAPDAFSTVSSIPDTTTPGGNQADPLDHLSSLMSSGGGGSTQRYQGYVSPRSLSTDSSTTGESPVHEGVQDQAFVGQNCSSAGGGGGGGGGGGNYFPTPSVFPTILYSQLYNNQFQTGTDSSDQQQQQQQQQQQHHQRGLTDVTGCSVVRVPDEVIRPDNNVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01484419;
90% Identity
iTF_01484419;
80% Identity
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