Basic Information

Gene Symbol
-
Assembly
GCA_902806795.1
Location
CADCXV010000712.1:16107-22558[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00047 0.02 15.3 0.1 1 23 63 86 63 86 0.97
2 10 0.0046 0.2 12.1 2.1 1 23 92 115 92 115 0.96
3 10 1.7e-05 0.00074 19.8 2.2 1 23 121 144 121 144 0.95
4 10 6.7e-06 0.00029 21.1 3.9 1 23 150 173 150 173 0.97
5 10 0.052 2.2 8.8 0.1 1 22 179 200 179 200 0.94
6 10 0.0041 0.18 12.3 0.5 5 23 200 219 199 219 0.94
7 10 0.00058 0.025 15.0 1.1 1 23 225 248 225 248 0.97
8 10 1.4e-07 5.8e-06 26.4 4.4 1 23 254 277 254 277 0.98
9 10 2.8e-06 0.00012 22.3 0.7 1 23 283 306 283 306 0.95
10 10 7.2e-06 0.00031 21.0 1.3 1 22 312 333 312 333 0.96

Sequence Information

Coding Sequence
ATGAAAAGCAGCAAGTGTGTTTATATAATTGTGGCACATAATGGGCGTTATACattagggggggggggggggggggggggggggggggggggggggggggggatcaACGAtaaTAAGAAATCCAATGAAATTGCCTCAAGAGTTAATTTAAAAGAACACGACCCTATTAattcagacgacaaaaaatacgtttgtgatatttgtcaggaggcatttacactagaatcaagcatgataacacacagagacacaattcacaatgaacgaaaagattatgcatgcgaccagtgcgaaaataaatttgagttccgaagtcatatgagtagacaccaaatatcagaacacaaaggccGAAATGAGTTTgattgcgacaagtgcgagaagaaattcgtgaaaaaatcaagtttgtttacgcaccaaaaattagtacataaagATCACGAATATTTCACGTGCGAAAAGTGCAacaagaaatttgaaaataaatcaactttacttaagcacaaaaaaatattccacgaagttttcaaagattacttatgtgaaaggtgcgccaagagatttggaatTAAACGGAGTTTGCTTGTGCACATTAAGACTtgtgaaaataaatttacacaaaaacagAGTTTATTCgcccaccaaaaaacagtacacgaaggtcacaaagactatgcatgcgacaaatgcgagatgAAATTTGCAGCAAAATCGTCTTTGCTTATGCACCataagacagtccatgaaggtagCAAAGATTATACATgcaacaattgcgagaagaaatttacacgaaaTTCGCATTTGCTCAACCACCAAcggacagtacacgatggtcgcagagattttgcatgtaataaatgcgaaaaaaaatttggatctAAATCAGATTTGATCAAGCATCAAAaagcagtacacgaaggtcacaaagattacgcatgtgacaagtgcgagaagaaatttacacaaagatcgagtttgctctaccaccaaaggacagtgttcATCTAG
Protein Sequence
MKSSKCVYIIVAHNGRYTLGGGGGGGGGGGGGGGINDNKKSNEIASRVNLKEHDPINSDDKKYVCDICQEAFTLESSMITHRDTIHNERKDYACDQCENKFEFRSHMSRHQISEHKGRNEFDCDKCEKKFVKKSSLFTHQKLVHKDHEYFTCEKCNKKFENKSTLLKHKKIFHEVFKDYLCERCAKRFGIKRSLLVHIKTCENKFTQKQSLFAHQKTVHEGHKDYACDKCEMKFAAKSSLLMHHKTVHEGSKDYTCNNCEKKFTRNSHLLNHQRTVHDGRRDFACNKCEKKFGSKSDLIKHQKAVHEGHKDYACDKCEKKFTQRSSLLYHQRTVFI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-