Basic Information

Gene Symbol
-
Assembly
GCA_902806795.1
Location
CADCXV010000849.1:107496-120116[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.081 3.5 8.2 0.3 6 23 22 40 22 40 0.97
2 16 0.17 7.4 7.2 0.2 1 16 46 61 46 62 0.91
3 16 0.053 2.3 8.8 0.4 1 16 81 96 81 98 0.88
4 16 0.14 6.1 7.4 0.8 1 23 110 133 110 133 0.94
5 16 4.5e-06 0.00019 21.6 1.1 1 23 139 162 139 162 0.97
6 16 0.0026 0.11 12.9 0.2 1 23 168 191 168 191 0.96
7 16 3.8e-06 0.00016 21.8 1.7 1 23 197 220 197 220 0.98
8 16 5.5e-06 0.00024 21.3 1.7 1 23 226 249 226 249 0.98
9 16 0.00012 0.0051 17.1 0.9 1 22 255 276 255 276 0.95
10 16 0.0026 0.11 12.9 0.2 1 23 284 307 284 307 0.96
11 16 3.8e-06 0.00016 21.8 1.7 1 23 313 336 313 336 0.98
12 16 1.7e-05 0.00071 19.8 1.1 2 23 343 365 343 365 0.97
13 16 0.001 0.044 14.2 0.9 1 23 371 394 371 394 0.96
14 16 3.7e-07 1.6e-05 25.0 0.3 1 23 400 423 400 423 0.98
15 16 5.3e-06 0.00023 21.4 0.4 1 23 429 452 429 452 0.97
16 16 2.7e-06 0.00011 22.3 2.2 1 23 458 481 458 481 0.97

Sequence Information

Coding Sequence
ATGACATATGTTACGGTGACGATTTCAACTGCAATTGTATCAACTCCAGCTAAAATTGTACCGtgtgcgaagagattcggaaataaGCAGAGCTTGCTCCTGCACAttaagacagtccatgagcgttgcaaagatttcttatgcgaaaagtgcgaggagatatttgtgaaaaaatcgcatttactATTTGACTTGAAGACAGTTCACAAAGAACAGAAAGATTTCAATGTCtccaaagattacttatgtgataattgcgggaagaaatttggaaatgaATCGAAATTGCTTTCGCCCATAACAACCGTCCACGAGgttcgcaaagattttgcatgcaacaaatgtgagaaaacAGATGGGAAATTtgtcaatttgaaaaaacaccAAAAtctagtacacgaaggtcgcaaagattacgcatgcgacaagtgcgagagaaaatttggatataaatcagatttgttaaagcaccaaaggacagtacacgagggtcgcaaagattttgcatgtgacatttgcgagaagaaatttggccGAAAATGGATTTTGGTTCAGCATCAAAAgtcagtccacgaaggtcggaaagatttctcatgtgacaagtgtgagaagaaattgactagaaaatcagatttgttgaatcaccaaaggacaatacacgaaggtcggaaagattatgtatgtgacgaatgcgggaagaaatttgggtatAAACAGCATTTACTCCAACACCAAAgtacagtccacgagggtcgcaaagattacacatgcgaccagtgtgagaggaaatttggatataaatcagatttgttaaagcaccaaagTACAGTCctcgagggtcgcaaagattttgcatgtgacatttgcgagaagaaatttggccGAAAATGGATTTTGGTTCAGCATCAAAAgtcagtccacgaaggtcggaaagatttttcatgtgacaagtgtgagaagaaattgactagaaaatcagatttgttgaatcaccaaaggacaatacacgaaggtcggaaagataaCGTATGTAACGaatgcgggaagaaatttggactcaaATCAGATTTATTCAAGCACaaaaagacaatacacgaaggtcgtaaagattacgcatgtgacaagtgtgagaaaaaatttgggcaaaaatcacttttgctttttcaccaacaaacagtccacgaaggtcgtaaagattatgtatgtgacgaatgcgggaagaaatttggacaaaactcaaaactaataatacaccaaaagacagtacacgagggtcgtaaagatttctcatgcgacaaatgcgagaaaaaatttggagagcAAGGtaatttgatcaaacaccaaaggatcgtacacgaaggtcgtagagattacgcgtgcgacaagtgtgagaagaaatttggacgaaaatcgaatttcttaaagcaccaaaaaacagtccacgaaCTATACCAATTTTACATCCTTTGTcccgccgtcgaccagcagccctcgctgcgctcgggccgcaaatgtcggcgggctttgccatgtaagcgtaaattcatggatacaatttttttaaataaaatatttcttaactATGTTAAGcaaacgtactttcgagcggggataaagaaaaatcgtatacgcgactcgggacaaaagtcaaacgcccgtctctgcgagcttgcaccctcggcttcgcctcatATACTATTTGTTGCAAAGTTTTGCGTGGTACTCATTTAG
Protein Sequence
MTYVTVTISTAIVSTPAKIVPCAKRFGNKQSLLLHIKTVHERCKDFLCEKCEEIFVKKSHLLFDLKTVHKEQKDFNVSKDYLCDNCGKKFGNESKLLSPITTVHEVRKDFACNKCEKTDGKFVNLKKHQNLVHEGRKDYACDKCERKFGYKSDLLKHQRTVHEGRKDFACDICEKKFGRKWILVQHQKSVHEGRKDFSCDKCEKKLTRKSDLLNHQRTIHEGRKDYVCDECGKKFGYKQHLLQHQSTVHEGRKDYTCDQCERKFGYKSDLLKHQSTVLEGRKDFACDICEKKFGRKWILVQHQKSVHEGRKDFSCDKCEKKLTRKSDLLNHQRTIHEGRKDNVCNECGKKFGLKSDLFKHKKTIHEGRKDYACDKCEKKFGQKSLLLFHQQTVHEGRKDYVCDECGKKFGQNSKLIIHQKTVHEGRKDFSCDKCEKKFGEQGNLIKHQRIVHEGRRDYACDKCEKKFGRKSNFLKHQKTVHELYQFYILCPAVDQQPSLRSGRKCRRALPCKRKFMDTIFLNKIFLNYVKQTYFRAGIKKNRIRDSGQKSNARLCELAPSASPHILFVAKFCVVLI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-