Basic Information

Gene Symbol
Hsf
Assembly
GCA_902806795.1
Location
CADCXV010001028.1:44312-94183[-]

Transcription Factor Domain

TF Family
HSF
Domain
HSF_DNA-bind domain
PFAM
PF00447
TF Group
Helix-turn-helix
Description
Heat shock factor (HSF) is a transcriptional activator of heat shock genes [1, 4]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [1]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [2]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [3]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [2]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [3]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 1 1.7e+04 -6.6 3.2 68 92 421 445 416 453 0.53
2 3 3.3e-37 5.5e-33 113.4 0.1 1 100 846 945 846 945 0.94
3 3 1 1.7e+04 -9.7 12.3 69 98 1293 1327 1277 1332 0.48

Sequence Information

Coding Sequence
ATGGACAATAAGTCTAAATTTGCGGATAGATTCAACGTTTTGTTGAATAATGAAACTCCAAATGGAATAGATCCTTACATATTCAATGACACAGAGCCTTACGTGGCACCAGGTGGAAAAAACATAAAGTTGATAGCTCCTAAAAACTCCAAAACACCTAGTAATACGATAAATAGACATAAGTCAAAaggaaaatgttttaaaacaaAGATCAAAGCTGAGTCTTCGCTCAGTAATTGTTTTAATGCTAACACACTAACAGAAGTCAATAGCAATTCTGTCAAGTCGCATTCAGACAAATTATTCGCGCTACAGCAAAGAAAGAAGTACCTGAAAGAGTTGGAGCAGTTGAAGGAAAAACGCAAAAGCCGCGATCATGATTTGTCGTATTATTCAAGAGCCGGTGATGAAATATCGGACAGCGAATCGAGCGGCGACGAAGTATATGTTTGTCAACGGCATTGGTATTCAAACGAACCTGATACGACTTTATCGAGATCGGCTCGCTTATCTCTCACACGCGCCCAGTTGCAAAGAAAACTTCAGCAGCTGCAAGTGGACGACAAATTGTACACggaaattttacgaaaaaatatgGAGTCCTTAACGAAGGCAGCAGCACTAGATCCAACAACGTCAGGTCGGATATTGAACGGCTCGCCGAGCAAGAAGAAGAACGCAGAAAATACCGGACCCGCGATCGTTGGTACCACTTGCAGCGTGACAGATTGCAATCTCACGTCGCTCCCGTGCACGCGGCACTGCGCGAAACACATAATGCTGAATCCCGAGCAACGACTCTTCGAGCACTGCACGGCCAAGTTCAGCGACAACACCCAGTGCTGCGTACCGGTGTTCGACGTCGCCCACGAATTGCCACTCTGCCTCGAGCACGCTCGCAAGAGGGACAACTATCATCGTAGAGCGCAGGAGTCGAAACCGAAGAAGCCGCGAAGCAAAAAGCCCACACCGCCCCCGGTGATACCGGTAACGCCGACGAACAACGTTTGCATGCCGGTGGGCAGTGGTAGCATAGGCAAAAACATTTGCAACAATGCCCTGGTAccggcagtagcagcggcagtgcCAACAGCTCCAGCAGTGGCACCAATCAAGCCGACCAAGGTGAAATCGAgaccaaagaaaaagaagaggccACCATCGCGAGATAAGGTGGAGGTATTCAATGTCACAACGAGCCATGAGCCACCCGAGCCAACGCCGCTTCCACCGACACCCCcacagcagctgcagcagcaacaacaacagcagccaccgcagcagcaacagcaacagcagcttcaacatccacagcagcagcaacaacaacagcaacaacaactacCACAGCAGCAACCacaacaactacaacaacCACAACCACCACAGCATCAACAACAGGTGCAACCGCAAGTTCTGCTACCGCCGCCGAATCTCGTTGTTCCGCCGATTTTGGAACCCATACCAGACACAGTACCGGCTAATCTTCTGGCCGATGAGAATCACTTTGTGAACTCGCTGATAGCCGGCAACGAAATAGTTGATCAAAAAACATTGAACAATCTCAACGTTGGCTACAATCCAGCGATCATGCCCAACAACcaaataaacaatttgaaCAGTTTAGCGCTTGATATCGGCACATTGGGTCTGACTAACGAAGTTTTTGCGTCGCTGGACCACGCGACGGAGCACGAATTCGAAAATGCTCTCATTAATTTGCCCCCGGATGCTTTCAACGATCTTTTTATTGAAGCGATTTATAGTATAGGCAGCCAAAGTTTTCATGAATGTgtggtaatatttttttttttttacaaaatattcatcataaATTGCTATCCAAACGATTCTGTGCGCGATCTGCATCATTCCCTCGAAAATCCTCAGGTCTTTGGCACCCTTGCTCTGAACGAACTGAATCTTGCCGGCTCCGACGTGATGATACCTTCGCGCTTCCCTCTGGCAAGCCGTCAAAATGTCCGCGTACTCTCGGGCCAGGCAGCACCTCAGAGCCGTCATCTCGTTGGACCTGTCGAGACGAGCCCCGCCGGCCAGCGGATTCGGGGCTCTCTTGGCCGTGGCCGCGCGTCGCTCGCCCAGCTCCTTCCACGTGACGATGTAATCTTGGAAGTAGAGTATGAGGGCGCGCAAGAAACGATCGACGATCGCCAGGTGCAGGAACTCGACGAGCTCGATCGTGATGGCGGTGTTGAGAAGATACAGCACGATGTCTTTGATGTCTTGCAGGAGCACCACGTCGTTAGCGCTGTTTTTCGACACTTGACGACGATAaaaaaagtcgcCAAGATTGTGGCAAACGGGAGAAATCCGAGCAACGCTAGCGGACAAGCTAGTGGAGCTTCGGCAGCATCGCGGACCACATCGTcgacgacagcagcagcgtcaacAGCATCATCCGCCGCTGCTCAACGAGCTGCTGCCACCGACGAGCCGAGAGCCACCACGAGCTCGAATTCTACCTCCAACGACATGCACACCATCTCGTCGGACATGGGCACCAGTGTGCCCGCCTTCCTCGGCAAACTCTGGCGCCTGGTCGAGGATCCGGAGACCGACGACCTGATATGTTGGTCCCCTAATGGAAGAAGTTTTTTCATCAGAAATCAAGCGCAGTTCGCCCGAGAGTTGCTTCcacattattataaacacaACAATATGGCTAGTTTCGTCCGTCAACTGAAtatgtatggCTTCCACAAGAAAGTATCAGTTGAACTTGGAGGCTTGAAATGTGATAGGGATGAGATGGAATTCGCTCATCAATACTTTTGTAAAGATCACCCttatttattggaaaatattaAACGAAAAATTGCTTCTAATAAAACTTCTGCAGACCCATCTCAAGCACCAATTCGACCAGAactaatgaataaaatgttAACAGAAGTGAGAAGTATGAGAGGACGTCAAGAGCATTTTGATACTCGACTTGGTGCCATGAAACGCGAAAATGAAGCTCTTTGGAGAGAACTTGCTATAATGAGACAGAAACATCTCAAGCAACAACAAATAGTTAATAAGCTTCTCAACTTTCTCATGTCTTTTGTACATAATAGAAATACTGGTTTAGCTATGAAAAGAAGGTACCCACTTATGATTGATGATGTCAACAGACAAAAGGCACCCAAAACGAAAATGGCCAAAGAGCAAAATTCACCCTTAGGTCCTGCAATTCATGAATTAGATACTTCTGATCCAGATTTCGATCCTGAGTACATTGTAGCAGACATTTTGGATAATGATCATCCTCCAACAATAGAGAGTCCAGAACATCAAAATGAAGACTCTATGAGAGATTTTTATGATGAAGAATCAATTCATTTACCTCAAGAAATTGAATTGTGCCCAGAAATCAATCAAAAGAGATTTAAAGGCAACAAAAAgGAAGAAACAGTACTGTTAGAAGTGCCAGACCATCATGTACAAAAAGTCAACAATTCAGTTTCTCCAATGCACATTGGTGTAGAAAAAACATCCAAAGTTAAACCAATAGGTAAACCAGTACCAGCCCAAACAGTTCGTAGTTCAAAACTAGCTGCAATGGCAGCTAACTTAAATGCCAAGAACAATCAGCAAAAACATCAccaaaagaagcaaaaaaaacctGTTATTAAAGTAGAAGATTATTTGGCAGTCCCTGATATCTTAAATGAAAACTATAGTCCATTGTTTGATGATAATGCCAGCACTGCTGCATCAAGTGTCAGCAGCCTTAGCACCAACAATGGCAGTCCATCTGCTAACAGTCCAGACAATACTTTTTCTAGTGGTTCTTTTGGTAATCTTGATTTTATCGAGGCCGCCATAactcaacagcaacaacaacaacagcagcaacagcagcagcaacaacaacagcagcagcaacagcagcagcagcagcagcagcagcagcagcagcagcaacaacagcagcagcagcagcaacaacagcaacaactagagcaactgcagcagcaacagaaacAACAATCGGAAGAGGACCAGAAAACCATGACATTAAGTTGTGTCAATACAAGTGGGACAAATGAAGCTACCTACAGGTTAGCATCGGTGAATGAAGTCGACACTCATCTTGGAACGGTGCAAAACGAACTGGATAATCTGCGCGATATGTTGAGAGGCGAAGGTTATAGCATCGACGCAAATACTCTTCTAGGAGTGAatcaATATCCTATCGCTAACAATAAAGAATTGACGCATTACGATTCCGAGTCGGATTTATTGAATTTCGATGACGATATGTTTCTGAACGGTGGAGCAACAGACACTTCTATGCAACAAATGGCGACCGATGCAACGAATAGCAACAATCTCGAAATTTATGAATTTGGCTATTGTCCCATTTGTTTTGTTGGCTGTACAGTAGTTTGTGGAGACGAAGATCctttggaaatgaaaaaaattatcaaaataaatATCGCAGACCAGGAGTCACTGAGATCGGAGCTTAACGGCAAGAACGTTAATTATCTGGTAGTCGACGAGAAATTCGAAGAGATGATAGGTTATATGAAAGATCGGCAAAATATTCATAAGCCACTCGTGGATTATATAAGGAAGTCCAAGGCAATTTTCAAGGTATATCTTAACTCACTTGACAACGTCTTGCCAATCCCACGCCCGAACACAACAGGCAAAGCGACCCAGACCTCATCGGGTCTGGCAGACCAAGTGCCTAAGATGAAGTCACAGGTGAAGAAGCAGGGTGGTGCTAAAAAGGCTCTGTTTTTGACCCCCATGGTGGCTAGCGCTACTGACACCACAAGCATCGTCGGCGGAGAGAGACAAAAATTCCAGACGAAGCGGCAAAGGGGCAGAGGCCCGAAGAAAGTGGAAGCTAGCGCCCAAAGCtcggcgagagagaagaagatcGACGTGTCGATCTTGTGTGACCAACACAGGCCTCTGCCAGCACCGCACATCTGGATATTGGACGCTGACAATCAAGCGACTATCTGCTGGATTAGCAGACTCACAAAGGACGGTCAACTATCAACGCTATACAGAAGGTGCTCAACACCGCCAAAGCAGCCATCAGCGGTAAGAAATACCGCAGTGTCACAAAGAAATATTGTCCACCGTCGCCCTGGACGTCAGGAACGCCTTCAACTCAGCGCGCCGGAATCATACCCTACGCTCCCTCGTGAAGATGGGAGTCCCAGCAGCTGGAGTTCTCTACGGATGATAACCTCACGGCTGGAATCCCCAGGGATCCGTACTTGGTCCTATCCTCTTGGAtgttataatttaaaagatGCTAAAAGAGTAAATACCTACCTTAGCGGCCGAAGGTGGCTATCTTCCTTACCGACTCtcgaacataacctataccaGCGTATTTCAAGCCATGAAGTTAGCATCATCGTACACCCGCCAAGTTACATAAGCGGACCTCGAAAATTTGAGATCGATCAGTCGCTTCCTTCATTGTTTATAAACAACAGCGCgATCATGGAGATAAAAGTAATGATGATTACATTGATGATTATAGTAACAaaatcgggcattaagaccctatgtgttgaaaattttttttcttactttttcggtataaatgatgaaattccaccgcactggatccgtgaaaaTCTTTCTTGCCCAACCTCACGatatattcatttccaaaaaattatgttgGTAAACGGGATCCCAATAAGATGGCTTAGAGAGGCTCGTCAGTACGAGCAGGAGCTTAATGAATACGAAATCGAAGCTTCGAACAGTCCGGAAAATGCTTGGAACCTGCGGGAGCTATTCTTATACAACGAGGAGTGGTTCACCATGTATACTGGCATGACGTTAATCTGGGACCCCAAAGATCCCAAAAAGGAACCCGAATCAGACATATATAGCATATAG
Protein Sequence
MDNKSKFADRFNVLLNNETPNGIDPYIFNDTEPYVAPGGKNIKLIAPKNSKTPSNTINRHKSKGKCFKTKIKAESSLSNCFNANTLTEVNSNSVKSHSDKLFALQQRKKYLKELEQLKEKRKSRDHDLSYYSRAGDEISDSESSGDEVYVCQRHWYSNEPDTTLSRSARLSLTRAQLQRKLQQLQVDDKLYTEILRKNMESLTKAAALDPTTSGRILNGSPSKKKNAENTGPAIVGTTCSVTDCNLTSLPCTRHCAKHIMLNPEQRLFEHCTAKFSDNTQCCVPVFDVAHELPLCLEHARKRDNYHRRAQESKPKKPRSKKPTPPPVIPVTPTNNVCMPVGSGSIGKNICNNALVPAVAAAVPTAPAVAPIKPTKVKSRPKKKKRPPSRDKVEVFNVTTSHEPPEPTPLPPTPPQQLQQQQQQQPPQQQQQQQLQHPQQQQQQQQQQLPQQQPQQLQQPQPPQHQQQVQPQVLLPPPNLVVPPILEPIPDTVPANLLADENHFVNSLIAGNEIVDQKTLNNLNVGYNPAIMPNNQINNLNSLALDIGTLGLTNEVFASLDHATEHEFENALINLPPDAFNDLFIEAIYSIGSQSFHECVVIFFFFYKIFIINCYPNDSVRDLHHSLENPQVFGTLALNELNLAGSDVMIPSRFPLASRQNVRVLSGQAAPQSRHLVGPVETSPAGQRIRGSLGRGRASLAQLLPRDDVILEVEYEGAQETIDDRQVQELDELDRDGGVEKIQHDVFDVLQEHHVVSAVFRHLTTIKKVAKIVANGRNPSNASGQASGASAASRTTSSTTAAASTASSAAAQRAAATDEPRATTSSNSTSNDMHTISSDMGTSVPAFLGKLWRLVEDPETDDLICWSPNGRSFFIRNQAQFARELLPHYYKHNNMASFVRQLNMYGFHKKVSVELGGLKCDRDEMEFAHQYFCKDHPYLLENIKRKIASNKTSADPSQAPIRPELMNKMLTEVRSMRGRQEHFDTRLGAMKRENEALWRELAIMRQKHLKQQQIVNKLLNFLMSFVHNRNTGLAMKRRYPLMIDDVNRQKAPKTKMAKEQNSPLGPAIHELDTSDPDFDPEYIVADILDNDHPPTIESPEHQNEDSMRDFYDEESIHLPQEIELCPEINQKRFKGNKKEETVLLEVPDHHVQKVNNSVSPMHIGVEKTSKVKPIGKPVPAQTVRSSKLAAMAANLNAKNNQQKHHQKKQKKPVIKVEDYLAVPDILNENYSPLFDDNASTAASSVSSLSTNNGSPSANSPDNTFSSGSFGNLDFIEAAITQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQLEQLQQQQKQQSEEDQKTMTLSCVNTSGTNEATYRLASVNEVDTHLGTVQNELDNLRDMLRGEGYSIDANTLLGVNQYPIANNKELTHYDSESDLLNFDDDMFLNGGATDTSMQQMATDATNSNNLEIYEFGYCPICFVGCTVVCGDEDPLEMKKIIKINIADQESLRSELNGKNVNYLVVDEKFEEMIGYMKDRQNIHKPLVDYIRKSKAIFKVYLNSLDNVLPIPRPNTTGKATQTSSGLADQVPKMKSQVKKQGGAKKALFLTPMVASATDTTSIVGGERQKFQTKRQRGRGPKKVEASAQSSAREKKIDVSILCDQHRPLPAPHIWILDADNQATICWISRLTKDGQLSTLYRRCSTPPKQPSAVRNTAVSQRNIVHRRPGRQERLQLSAPESYPTLPREDGSPSSWSSLRMITSRLESPGIRTWSYPLGCYNLKDAKRVNTYLSGRRWLSSLPTLEHNLYQRISSHEVSIIVHPPSYISGPRKFEIDQSLPSLFINNSAIMEIKVMMITLMIIVTKSGIKTLCVENFFSYFFGINDEIPPHWIRENLSCPTSRYIHFQKIMLVNGIPIRWLREARQYEQELNEYEIEASNSPENAWNLRELFLYNEEWFTMYTGMTLIWDPKDPKKEPESDIYSI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-