Basic Information

Gene Symbol
RREB1
Assembly
GCA_015345945.1
Location
JADDYM010000091.1:2678345-2684618[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 2.3e-05 0.0016 18.8 0.8 1 23 47 69 47 69 0.99
2 16 0.00016 0.011 16.2 0.3 1 23 81 103 81 103 0.98
3 16 0.00017 0.011 16.1 6.2 1 23 109 131 109 131 0.98
4 16 0.39 26 5.5 0.1 1 21 177 198 177 201 0.75
5 16 0.0018 0.12 12.8 1.0 2 23 207 229 207 229 0.97
6 16 0.043 2.9 8.5 1.4 1 20 274 293 274 295 0.94
7 16 0.058 3.9 8.1 0.1 1 23 417 439 417 439 0.96
8 16 6.6e-06 0.00044 20.5 0.8 1 23 448 470 448 470 0.99
9 16 0.00067 0.045 14.2 3.1 1 23 476 499 476 499 0.97
10 16 0.0004 0.027 14.9 3.0 1 23 824 847 824 847 0.97
11 16 0.00045 0.03 14.7 0.5 2 23 1058 1079 1057 1079 0.97
12 16 0.1 6.8 7.3 6.3 1 23 1085 1108 1085 1108 0.97
13 16 0.034 2.3 8.8 1.1 1 20 1136 1156 1136 1157 0.94
14 16 0.31 21 5.8 0.7 1 23 1209 1232 1209 1232 0.92
15 16 0.013 0.91 10.1 0.4 3 23 1279 1299 1277 1299 0.93
16 16 0.0061 0.41 11.2 5.9 1 23 1305 1327 1305 1327 0.98

Sequence Information

Coding Sequence
ATGGAGGTAGAACCCGAATCCAGGAAGGAGGAAAGCACCCAAAGCGACTCCGGCATCTTCTCCGCCACCAACACCACCGCCACCATGGACCCTTGCGACACCGACAACCGCAGCGACTGCAGCTCCCCCGAACGCAAGTACGTCTGCCCCATCTGCGACACCATGCTGACCTCCCAGCACGAATTCACCCTCCACATCCGATCTCACAACAACGAAACGGAGGCCCAAGACGACAAGGGCTTCACGTGTCGCATTTGCTCCAAAGTACTCAGCTCGAGCTCGAGTCTGGACCGACATGTCTTGGTCCACAGCGGCGAAAGACCCTTCCATTGCCGCTACTGCGGCGACACCTTCACCACCAATGGAAATATGCACCGCCACATGCGGACCCACACCCACAAAACCGACAATTACGAATCCGACGGGAGCACCGACAGCGGAAGCTCCAAAAGCACCGAATTCAACAACAATAAAGTCGAGTCGAAGAAACGCAAACTGGAAAACTCGAGTGACAACGAAACACAGTTTTACAAATGTCCCGTTTGTGACCGGACCGATTTTGACTCGATTGTGGCCCTGGAAACACACTTGGAGGACAATCATCCAGATTATCCCGCCAAGTGTGGGCAATGCAACCAAATCTTCCAAAACAACAAGCTTTTGACCATCCATCGCAACACGGTTCATTCCAGTACCAAGAAACACACTGTTTCTGGGTTCAAAGACTTGACTTTTGTCGACTTCTCCAGCGAGAAGTTTCCTTATATCGCGCGGTATGAGTGCGAGAAGAACCTCCACACGGCTTCCGATGGACTCACTTTCCAATGCAAGACCTGCACTAGGGCGTTCCCCTGCTCCAGCTCCTTGCAAATCCACGAAAAAGACTGCTTGAACCAACACAATGGGCTGGATTTGAGCAAAACCCAAGTCTCCGAGAAGGACATCAGGAGGAATGAGTTCTTCTCCCGACTTAACTTGCAAGATAACTCCCCCGAAAAGTTCATTCCTCCTCAAATGAGCGAAACTTCGACCAAACTCAGACAACAACTTTTGTCCAAAGTCATGACCAATGACTCGAAAGACCTGGCAGATATCCAGAGTATCATCTCGATGACCACCAATGGAAGTCTCTTGCAACAACTTCGCACCAAGAACGATTTAACTCACGAGACTCAGAAAACAGAACAGGAGGAAGAATCTCAGGATTTGTTCGCAGTGGAGTTCCGGAAGATGAAACTCCGAGGGGAGTTTCCTTGTCGTCTTTGCACGGCAGTTTTCCCCAATTTGCGGGCCTTGAAGGGGCACAATAGGGCCCATCTCAATGGTAACAACAATGGGATGTATCGGTGCAACATGTGCCCCCATTCGTCCATCGATAAAGCAGCTTTGATAAGACACATGAGGACCCATAACGGGGACCGACCATACGAATGCTCTCTTTGCAATTATGCCTTCACCACCAAAGCCAACTGTGAACGGCATTTGAGAAACCGACATGCGAAAACAACACGTGAGGAGGTCAAAAAAGCCATAATCTACCACCCATCCGAAGACCCCACCAACGAGGATTTAAATAAGTTGGCAGAGCCCCGGAAAACTACCACTGATGTGACCCCGGAGAAACCCCTCACTCCCTTGATCCCCACTCTCCTCAAGGAAACGCTCAATGTCCCCCTTCCGAAAGAACCCCCACTCTTCTCCAATATCATCAGGAGTGAGAATTTGAAAAGTCTCAAAGAACGCCCCCCAAATGGCCAATTCTCCCCTTACTTACCCTATAACTTCTCGCCTAAATCCTCAAACGTGTCAACTCCTCATTTGTCCTCAAAAATCCACGTCAAGAATTTAGAGGAGCTCAAAGAGCAGCAATCGGATCAGGAATGTGAGGATCAAGAGGAGGAACCAATGAATCTAGTCCTGGATTTGAGTAAGAAGAAAGAGGTCAAAAACGAGCTCCCTCAGGATTTGTCCAAGAAAACTCCAAGTCCCTCACATGTGAGGGATTTATTTGCCCAACAACTACTCAAAAGTCCTCCGAAAATCGATCCGGCGGCTCTTTACGCCTCACTTTACCGGAGTAGTTTTCCGGGGTTCACCGGATGGCCCGGATTGCCTCTAAACCCGCTCATTTTCTCCTCCCTGCAACCTCCCATTCTTCCCCCGGAGTCGCACGAGATGAAAGAGAGGTTGCAGAGGTACCAGTTTTGTGGCGGGTCAATGATCAGTGACAATTTTACTGAACGATTGAAGACGTTTCAAAATCCGGGTTTTGCGCCCGATTTGAAGAAACCGGAGGATTTGAAACCGTTGAGCTTGAATGTGGAGTCGAGTTTTGGAGACAATTACAAATTGCAGAGTCCTATTGCCAAGCCCGATTTGACTCAGTCCCCGAATTCGGTCAAAATGGTGATCAAAAATGGGGTTTTGATGCCGAAACAGAAGCAGAGGAGGTACAGGACTGAGCGTCCCTTCACCTGCGAACACTGCTCAGCGAGGTTCACTCTCAGGTCGAACATGGAGAGACACATCAAGCAACAACATCCTCAGTTTTGGTCGCAACGCCAAAGAGGAGTGAGCAACCCAGGGCGCAAAAGCCAACTGAAGAGTTACTGTGATCTCAGTATACCAAACTACGAAGTACCAAAAACTCAGGATTATGACGATACCAAAGAACACATGGATGAGAAAATAAAGTTTGCGATTTTGGCCCAACATCTGAGGGTTAATCAAGAAATCAAGAAGGATGATGATGAAGATGGTGATCTTGTGATCGACGAGAACGCCGAAAAGGTTGATTTGAAGACTGAAGATAACAACCAAAGACATTTTGAGACGGGATTTGAACGAAGTAAGATTCTAGAGGAGAAACTCAGGGAGTTGCATGCGAAACAGATCAAGTCGGAGAAAGTGAAGAATGAAGAGAGTCAGGATTTGGTACCAGTGTCCAGGCTTTTGGACAATGCTTCCCAACAACAGTTCAAGGAGTTTTTCAAACGCGAGGGGGAGGAGCCGGAAGTGGGAGGCGCCAGCGAGGAGGATGAAGAAGGGTTGGTCGCCAGTGGGAGCACTAGCGAAGGGAACATCTCAGGAACGGACGAAAATAAATCCGAGTCGGAGGCCGCCGCCCCCGCCAAGAAGAAATCCGCCTACTCCATGGCCCCCAACCGCGTGAGTTGCCCCTTCTGCAGCCGCAAATTCCCATGGAGCTCCTCCCTCCGCCGCCACATCCTCACCCACACCGGTCAAAAACCCTTCAAATGCAGCCATTGCCCTCTCCTCTTCACCACCAAATCCAACTGCGACCGCCACTTGCTGCGCAAACACGGCAACAACGCCACCACCATCACCAACGACGCCGTCAACAACAACACCAACTACTTGATGCGCAACGTCCCCGAACGCCCTTTCAAATGCTCCAGCTGCCCTAGCAGCACCTTCTCCACCTACTCCAACCTCAAAAAGCACATCAGTTGCAAACACTCCGGGGACGACATCAAGGCCCAAGGCTACGAGGCCGGCAGCTCCGAGGACGAGAAACTCCCCCCAAGCGAGACCAAACCCGACTGGGAGGAGCCCAAAAAGGGGCCCACTGAGGCCCCAATGGTGCAAACCTCCGACCTGCCCTTCAAGTGCCACTTGTGCGACGGCTCTTTCGGGGAGCGCCAGGACGCCCTCGACCACATCAAAGACAAGCACTTCACCGAGTACGATTTACTCATGTCGAAGAATGCGTTGGACAACAACGCGACAACCCCTGAGGAAGGGGGCCACCACGAGGACGAAGAGAACGACATGAGGGGCAAATTCCCGGATTACTCCAACCGGAAGGTCATTTGCGCCTTCTGCATGCGCCGGTTTTGGTCGGCGGAGGACTTGAGGAGGCACATGAGGACCCACACGGGGGAGCGCCCCTTCAGCTGCGACATCTGTCGACGCAGATTCACCCTCAAACACAGCATGCTGCGTCACCGGAAGAAGCACAACGTCAATTTTGACAGCGAGGTGGTGGGGAGCGACGAAGACAACAACGCCCCCTCGAATTTCGAGAAATTCGCCAAAATTGACAACAACAACATGCAAAATAAGGAGGAATCGGATGGGAATGAAGGTAGCGACTTGATTAGTAAGTTATTGGGGATCAGGGATAGGTCTATTATCGATAAGGTACTAACGGCATCTGCCGACGATGCCGCTAAACTACTTGGGGTCAAAAACGGGGAAAAAGAGTAA
Protein Sequence
MEVEPESRKEESTQSDSGIFSATNTTATMDPCDTDNRSDCSSPERKYVCPICDTMLTSQHEFTLHIRSHNNETEAQDDKGFTCRICSKVLSSSSSLDRHVLVHSGERPFHCRYCGDTFTTNGNMHRHMRTHTHKTDNYESDGSTDSGSSKSTEFNNNKVESKKRKLENSSDNETQFYKCPVCDRTDFDSIVALETHLEDNHPDYPAKCGQCNQIFQNNKLLTIHRNTVHSSTKKHTVSGFKDLTFVDFSSEKFPYIARYECEKNLHTASDGLTFQCKTCTRAFPCSSSLQIHEKDCLNQHNGLDLSKTQVSEKDIRRNEFFSRLNLQDNSPEKFIPPQMSETSTKLRQQLLSKVMTNDSKDLADIQSIISMTTNGSLLQQLRTKNDLTHETQKTEQEEESQDLFAVEFRKMKLRGEFPCRLCTAVFPNLRALKGHNRAHLNGNNNGMYRCNMCPHSSIDKAALIRHMRTHNGDRPYECSLCNYAFTTKANCERHLRNRHAKTTREEVKKAIIYHPSEDPTNEDLNKLAEPRKTTTDVTPEKPLTPLIPTLLKETLNVPLPKEPPLFSNIIRSENLKSLKERPPNGQFSPYLPYNFSPKSSNVSTPHLSSKIHVKNLEELKEQQSDQECEDQEEEPMNLVLDLSKKKEVKNELPQDLSKKTPSPSHVRDLFAQQLLKSPPKIDPAALYASLYRSSFPGFTGWPGLPLNPLIFSSLQPPILPPESHEMKERLQRYQFCGGSMISDNFTERLKTFQNPGFAPDLKKPEDLKPLSLNVESSFGDNYKLQSPIAKPDLTQSPNSVKMVIKNGVLMPKQKQRRYRTERPFTCEHCSARFTLRSNMERHIKQQHPQFWSQRQRGVSNPGRKSQLKSYCDLSIPNYEVPKTQDYDDTKEHMDEKIKFAILAQHLRVNQEIKKDDDEDGDLVIDENAEKVDLKTEDNNQRHFETGFERSKILEEKLRELHAKQIKSEKVKNEESQDLVPVSRLLDNASQQQFKEFFKREGEEPEVGGASEEDEEGLVASGSTSEGNISGTDENKSESEAAAPAKKKSAYSMAPNRVSCPFCSRKFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNNATTITNDAVNNNTNYLMRNVPERPFKCSSCPSSTFSTYSNLKKHISCKHSGDDIKAQGYEAGSSEDEKLPPSETKPDWEEPKKGPTEAPMVQTSDLPFKCHLCDGSFGERQDALDHIKDKHFTEYDLLMSKNALDNNATTPEEGGHHEDEENDMRGKFPDYSNRKVICAFCMRRFWSAEDLRRHMRTHTGERPFSCDICRRRFTLKHSMLRHRKKHNVNFDSEVVGSDEDNNAPSNFEKFAKIDNNNMQNKEESDGNEGSDLISKLLGIRDRSIIDKVLTASADDAAKLLGVKNGEKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01568293;
90% Identity
-
80% Identity
-