Tmad009266.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Tribolium madens
Gene Symbol
TEAD1
Assembly
GCA_015345945.1
Location
JADDYM010000003.1:5769746-5772727[+]

Transcription Factor Domain

TF Family
TEA
Domain
TEA domain
PFAM
PF01285
TF Group
Helix-turn-helix
Description
The TEA domain is a DNA-binding region of about 66 to 68 amino acids that has been named after the two proteins that originally defined the domain: TEF-1 and AbaA. The TEA domain is located toward the N terminus of eukaryotic transcription factors of the TEA/ATTS family. It shows a three-helix bundle with a homeodomain fold [3, 1]. Two α-helices are nearly anti-parallel and pack on either side of the third one, which is the DNA-recognition helix of the TEA domain. Phosphorylation of one or both of the two conserved serines found on the DNA-binding surface could interfere with DNA-binding activity, by introducing electrostatic repulsion and/or steric hindrance, and help regulate the transcription factor activity of the proteins [2, 1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.4e-17 1.2e-13 51.1 0.4 36 66 7 37 3 39 0.95

Sequence Information

Coding Sequence
ATGTTGGAGGAGGGTGACGGTCGAAACGAACTCATAGCACGATATATCAAATTAAGGACTGGAAAAACACGTACAAGAAAACAAGTCAGTTCACACATACAGGTGTTGGCAAGGCGAAAACTGAGGGAAATTCAAGCCAAACTGAAGGTAGACCATGCAGCCAAGGAGAAGGCTCTGCAAACGATGTCGAGCATGTCAAGTGCGCAGATAGTATCAGCTACTGCAATGCACAGCAAGTCAGCAGGTCTGAGTCTTGGTCTAACTCCCCCCGTCTCCTATACTGGAGCGCAGTTCTGGCAGCCCGGATTACAACCAGGAACCAGTCAAGATGTTAAACCGTTCACACAATCGTCGTATCCTGCTGGTAAGCCTGCGACAGCAGTCTCAGCAGGGGACGTTGGACCTCTGCAAACAGCCCCACCGCCGGTCTGGGAAGGACGGGCCATAGCCACTCATAAACTTAGACTTGTTGAATATTCGGCCTTTATGGAATCGCAAAACAGAGACGAAGCATATCAGAGGCACTTATTCGTTCATATAGGCGGCCCGGCTTTATCATACACCGATCCTTTACTTGAGGCCGTGGACGTCCGACAAATCTACGACAAATTCCCGGAAAAGAAAGGCGGTTTAAAAGAATTGTATGACAAAGGACCCCAGAACGCCTTCTTCCTTGTCAAATTCTGGGCTGATTTGAATTCCAATATTCAAGACGAGGCTGGTGCCTTTTACGGTGTGACGAGTTCGTATGAAAGTAACGAAAATATGACCATCACATGTTCAACAAAAGTGTGTTCGTTTGGGAAACAAGTCGTGGAAAAAGTCGAGACGGAATACGCTCGTTACGAAAACGGCCGATTCGTCTACAGGATCCATCGAAGTCCCATGTGCGAATACATGATTAATTTCATCCACAAACTCAAGCATCTACCCGAAAAGTACATGATGAACAGCGTCTTAGAAAATTTCACTATACTACAGGTGGTGAGCAATCGAGACACGCAAGAGACCTTACTGTGTACGGCGTACGTGTTCGAGGTGTCGACGTCAGAACACGGCGCCCAACATCACATCTACAGGCTCGTAAAAGACTAG
Protein Sequence
MLEEGDGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKLREIQAKLKVDHAAKEKALQTMSSMSSAQIVSATAMHSKSAGLSLGLTPPVSYTGAQFWQPGLQPGTSQDVKPFTQSSYPAGKPATAVSAGDVGPLQTAPPPVWEGRAIATHKLRLVEYSAFMESQNRDEAYQRHLFVHIGGPALSYTDPLLEAVDVRQIYDKFPEKKGGLKELYDKGPQNAFFLVKFWADLNSNIQDEAGAFYGVTSSYESNENMTITCSTKVCSFGKQVVEKVETEYARYENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVSNRDTQETLLCTAYVFEVSTSEHGAQHHIYRLVKD