Basic Information

Insect: Tribolium castaneum
Gene Symbol: topi
Assembly: GCA_000002335.3
Location: NC:2829884-2834542[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 0.0063 0.37 10.9 1.9 2 21 97 116 96 117 0.94

2 13 1.9e-07 1.1e-05 25.1 0.7 1 23 142 164 142 164 0.97

3 13 0.015 0.91 9.6 3.3 2 23 171 192 171 192 0.95

4 13 0.038 2.3 8.4 0.5 2 14 211 223 210 229 0.86

5 13 0.001 0.062 13.3 1.2 2 23 266 287 265 287 0.97

6 13 0.32 19 5.5 3.0 2 21 330 349 329 353 0.83

7 13 0.14 8.1 6.7 0.1 1 23 463 486 463 486 0.96

8 13 0.01 0.61 10.2 0.2 1 23 490 512 490 512 0.96

9 13 5.5e-07 3.3e-05 23.6 2.4 1 23 518 540 518 540 0.98

10 13 0.015 0.9 9.7 0.2 1 23 546 571 546 571 0.96

11 13 0.033 1.9 8.6 2.7 1 23 577 599 577 599 0.86

12 13 4.9e-05 0.0029 17.5 0.5 3 23 607 627 605 627 0.97

13 13 0.00028 0.016 15.1 1.7 1 23 633 656 633 656 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	0.0063	0.37	10.9	1.9	2	21	97	116	96	117	0.94
2	13	1.9e-07	1.1e-05	25.1	0.7	1	23	142	164	142	164	0.97
3	13	0.015	0.91	9.6	3.3	2	23	171	192	171	192	0.95
4	13	0.038	2.3	8.4	0.5	2	14	211	223	210	229	0.86
5	13	0.001	0.062	13.3	1.2	2	23	266	287	265	287	0.97
6	13	0.32	19	5.5	3.0	2	21	330	349	329	353	0.83
7	13	0.14	8.1	6.7	0.1	1	23	463	486	463	486	0.96
8	13	0.01	0.61	10.2	0.2	1	23	490	512	490	512	0.96
9	13	5.5e-07	3.3e-05	23.6	2.4	1	23	518	540	518	540	0.98
10	13	0.015	0.9	9.7	0.2	1	23	546	571	546	571	0.96
11	13	0.033	1.9	8.6	2.7	1	23	577	599	577	599	0.86
12	13	4.9e-05	0.0029	17.5	0.5	3	23	607	627	605	627	0.97
13	13	0.00028	0.016	15.1	1.7	1	23	633	656	633	656	0.98

Sequence Information

Coding Sequence: ATGAATAATAGCCCAGACGAGCGGATAATTTCCGTGATAAACACGCATTTCATAAGCGACTGTGGGAAAAGCTCCTCGATGAGGTATGAGAGCGACTTCTTCAGCCACCAAGTGCTAAGCAAGAGCCCCTTTTTCTGCGTCCGAAACGTAAGTTTTAGTAGCGATGAGTTGAATTTTAGTCAGTGTCGAATTTTCAACGAAGACCTCGGAACCGTGCGCTTGTACAAAGCGGAGGATCCGCAGATTTTGCTCAAACGCAGGCAAAAGCTCAACATTCCGAGCATGATCAGGTGCCAGAACTGCGAAACCAACTACCCCACCAAATACCAGTACCAGAGGCACCAGTGCGAGTTTAACGCCGAGAAAGTGGTGCTTAAGCCAAACGCCGACTTCATCGACATAGACAAGGGCAAGCGCGTCAAGTACGATTGTCCGACGTGCGGCAAACAATTCGTCAGCAAGAACAACCTGGAGCGGCACCAAAGCAGCCACGAGAGCTCCAAAGACAACACGTGCGAGCACTGCAAGAAGCAGTTCGTCAGCGAGAACCGCCTCCGCATCCACAAGGAGAACCACTGCAAAAAAGCGGGCGACATTTCCAAGTTTTACCGGAGCGACGTAACCGTCTGGAAGTGCAAAAAATGCCACGAGGTGTTTTCCTCCAGCACGACGGCGGGGTACCACGTTGAAGACTGCACTGAATTGATTGACTCGTGTGATATCAAAACCGAGCCAGTGAACGATAACCGAACTGAGACCAAAACCATCGAGAAAATTTCGACCGAAATTCTGCTACAGTGCGAGTTTTGCAACCGCACGTACGCCGACAAGCAAATCCTGCTCAAGCACCAGAAGACGCACAAGACCGACAAAAACTACGAGTGTGTGGTGTGTAAGGACGTTTTCGACTCGTACATCACCGCATCGCAACACTGGCTCAAGAAATGTTCGGAGAAGGCGAACTTGTTTTATTTACCCAAACTCACCTATTGCGAGTTTTGCGACCGGACGTTCAAATCGCACGAAATCCTCTACACCCACAAGATCAAAAAGAAGCACTACACTCCCAAAATCCACGATAATATCGCCGAGAAGGCGAGTCAAGTCAAGGATATTAAAAACGAGGACGTTATTGATAAGTTGATCGAGGATGTGCTCATAGCACTCGAGATACCGATCAACAAACGCAAGAAAGTCGAGACTGAGAATAAGGAGAATGTGGTGCCAGATGAGACGATTCAAGTTAAGACGGAGCCCTTGAGCCAGAATGATCCCTTGGATGAGAGTGGAGCGCCTGAGAAGAAGAAAAGGGGGCGCAAACGCAAGTTCCCCAAGCAGACGCCAAAGGCGAAGAAACCGTGTGTGGCTCTGGATGAGGGTTTTAAATATCAGTGTGAGCGATGCACCGAAGTGTGGAATACAATAACCGAGTTGGAGGCGCATCGAGAGAAGGAACATGCAGCTAACTTCAACTGCGATGAGTGTGGACAGGTTTTGCACAGCGCGCGAGCCCTGTTGATCCACAGCCGGGCGCATAAGAGCCTCAAACCGTACGTTTGCGACACTTGCGGTCGTAGCTACTCACAAACGTCGCATTTGTGGCAACATATGCGTTTCCATCAAGGGATTAAACCGTTTGCGTGTCCGCACGAAGGCTGTGAAGCGAGATATACAATTCGGCCAGATTTGAAGGATCATATACGGAAAGTGCACACAAGGGAGAGACCCTTCAAATGTAGTGTCTGCGGCAAGTGTTTCCTGACCGGTTCGGTTTACTACCAACATCGGCTTATACATACGGAGGATCGGCGATATGGATGCGATATGTGCGAAAAACGGTTTTTTAGGGCCGATGCTCTGAATAACCACAAGAGGATTCATACGAATGAGAGGCCGTATCCGTGTTTTGTTTGTGGGAGGTTGTTTAGACAGAAAGGGGACAGGAATAAGCATTTTAGGACGCAGCATCCCGATGCCATCTTGAATTGA
Protein Sequence: MNNSPDERIISVINTHFISDCGKSSSMRYESDFFSHQVLSKSPFFCVRNVSFSSDELNFSQCRIFNEDLGTVRLYKAEDPQILLKRRQKLNIPSMIRCQNCETNYPTKYQYQRHQCEFNAEKVVLKPNADFIDIDKGKRVKYDCPTCGKQFVSKNNLERHQSSHESSKDNTCEHCKKQFVSENRLRIHKENHCKKAGDISKFYRSDVTVWKCKKCHEVFSSSTTAGYHVEDCTELIDSCDIKTEPVNDNRTETKTIEKISTEILLQCEFCNRTYADKQILLKHQKTHKTDKNYECVVCKDVFDSYITASQHWLKKCSEKANLFYLPKLTYCEFCDRTFKSHEILYTHKIKKKHYTPKIHDNIAEKASQVKDIKNEDVIDKLIEDVLIALEIPINKRKKVETENKENVVPDETIQVKTEPLSQNDPLDESGAPEKKKRGRKRKFPKQTPKAKKPCVALDEGFKYQCERCTEVWNTITELEAHREKEHAANFNCDECGQVLHSARALLIHSRAHKSLKPYVCDTCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCGKCFLTGSVYYQHRLIHTEDRRYGCDMCEKRFFRADALNNHKRIHTNERPYPCFVCGRLFRQKGDRNKHFRTQHPDAILN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01481174;
90% Identity: iTF_01481174;
80% Identity: -