Tcas004426.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Tribolium castaneum
Gene Symbol
br
Assembly
GCA_000002335.3
Location
NC:15426342-15431453[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00069 0.04 13.9 4.2 2 23 264 285 263 285 0.96
2 13 8.8e-05 0.0052 16.7 1.6 2 23 290 312 289 312 0.95
3 13 5.6e-05 0.0033 17.3 3.5 1 23 432 455 432 455 0.96
4 13 2e-05 0.0011 18.8 5.2 1 23 461 483 461 483 0.99
5 13 0.018 1.1 9.4 3.1 1 23 491 513 491 513 0.95
6 13 0.00022 0.013 15.4 0.9 1 23 519 541 519 541 0.98
7 13 3.3e-05 0.0019 18.1 2.1 1 23 550 572 550 572 0.97
8 13 5e-05 0.003 17.5 3.0 3 23 580 600 578 600 0.96
9 13 4.4e-05 0.0026 17.7 1.0 1 23 606 628 606 628 0.98
10 13 4e-07 2.3e-05 24.1 2.0 1 23 634 656 634 656 0.99
11 13 0.00011 0.0064 16.4 0.4 3 23 664 684 663 684 0.99
12 13 4.2e-06 0.00025 20.8 0.4 1 23 690 712 690 712 0.98
13 13 2.2e-07 1.3e-05 24.9 1.5 1 23 718 740 718 740 0.99

Sequence Information

Coding Sequence
ATGGGGTCCGATTCCAATAAGGAATATTCAGTGAATTGGAAAAACCACATGGACCATATGCGAAAAGCGTTCGATAATTTACTAACTTCGAACGAACTAACCGATGTTACTTTGTGTTGTGAGGGTCGTAGGATTGGGGCCCATAAAATGCTCCTCTCGGCATGTAGTACCTACTTTCGGGACACTTTTAAAGACGTGCCTTGCCAGCACCCTGTCATTATTTTGTACGGGGTGGAATATAGTGTTTTGTCAGATATTCTTCATTTTATTTACAATGGGGAAGTTAGTGTAGATACCTCAAAACTGGACTCGTTTTTAAAAACAGCACAGTTGTTAAAAATTAGTGGACTCACTGATAACTCAACTGAAAATATGGCAAGTGAAAATAGTGAGCAGGACACACAAGCGGCCAGTAGAAGGGAACAGACAGAGGGGGCTTTCAGCGAACAAGTATCAACAGCAAGTGAGGACACCAAAAAAGGGGCGAAGAGGAGAGTACAAGAATCAGAAGGAGCACCAACGCAGACTAAAGTGGGTAGGCAAGAAAGTGATACGCTTTTTATGTCGGATGTAAAGTCGGAACCTAGTGAGTTTGTCAATTATGAGGATCCTTTAGAAGACCCACTTTTACAAGCTGATCCATCCAATGAAAATAGGGAATTTTTTGTGACAAGTCAGGGGGGCGTCGAGGACGAGATTAAAATTGAGAGGACATCTCTCGAGACAACGACACTGGTGCGGGATACCGACATCAAAGTCAATAAGAGTAATTTTTCCGAGGAGTCGTTGAGGTGTCCCATTTGCAGCAAGTTATTTTCTCATCCGTACAGCTTACACCATCACAAAGCCGTGCATTCGGGCAACACTGAATGTTCGATATGTCATGTTGTACTCTCGCGAAAATACAACTTGAAAATGCACATGAAAGCGCGTCACAACTTGCAATTTATTGTCCAAGAAATGGACAAGAAATATGAGAAACACTGCCGAATCTGTGTAAAAGAGACAACAAACGGTGTGTATTTATTTGACGCAACAATTTCTGACAGTGAGACCTACATTGTTGATTTTTTACGCCAAATAACGAATTTGGAGATAAGTGAAGACGATGGCCTTACGAATATTTTATGTCCTACATGTGTTACCAAAGTTTTTGACTGTTTTGATTTGGTCCAAATATGTATTGCTTCAGATGCTATTCTTCGGAGTGCTAAGGACACGAAATGTGATTCAAATAAGCAAAATAGTGATTTAATCAAATCAGAAGACCTAAATTTGCCTAAAGATAGTGAATTTCAATGTAGGATTTGTAAATTGACTTTCAGCAATAAAACTAGCCTGAACAAACATAATAAAAGTACACACAAGGACGACAATCCTTTTAAATGTGATCAGTGTTCACAATCATTTCGGAAAAAGATGCACTTGAATGTACATCAACGCTCACATACCAAAGACGAGGATAAGAAGTTTTTTTGTAAAAGTTGTGACAAACAATTCATGTATGAATATTTACTGAGACAGCATGAGTACAAACACACGGATGAGAAACCTTTTCCCTGCAGTGTCTGTAATAGAGGGTGCCTTACTGCGGAAAGCTTAAGACGCCACATGCGAATCCACGATCGAAATTACGTAAAAAAGAAGCACTCGTGTGAAATTTGCCACAAAGAATTCCCCTACCCTAGTTTTCTAGCTGAACATATGAAAAATCACACCGGGGAAAAACCTCACTTGTGCTCCACTTGTGGTAAGGGTTTTCGACAAAGTGGAGCCTTACATTACCATCAGAGGATTCACACTGGTGATAAAAAATTCAGTTGTACGATTTGTAATGGACGTTTCATGTCTCAAAGTGTTCTAAAAGTGCACATGCGAAAGCACACAAATGAAAGGCCTTACGTTTGCCATATCTGCGGTATGGCGTTTAGACAATCAACGGACATGAAAAGTCACCAAAGAACCCACAGTGGTGACAAACCAGTACTGTGTAATATTTGTGGCAAGCGGATGTCAACGACCGGCCAACTAACCATTCATATCAGATCTCACACCGGCGAAAAGCCGTTTTCTTGCTCAAATTGCCCTAAAGCGTTCACGTCTAGGGCGATGTTAGTCAAACACGAACGGATTCATACAGGAGAGAGGCCGTATCGATGTAATGTTTGTGGCAAAGCGTTCAATCAAAGCGGGACTTTAAGGACGCACAAAAAAACTCATGAATGTGATAAGAAACGGAGAAAAAGTGAAAAACAAAAAGAAGTTATCGAGGATAAGGCCTATCAAAGTTCGGACGCTGTGTTTTTCAAAAACGAATTTGTCAATTTGGAAACTGAGATTGTTACTGACGAGTTTATTGGTAGTAACGTCCAGGATATTGAAGTTAAGACGAGTGATGGGTGTATGAAAACTCAACTGACGCTTATTCTGCCTGCGCCTATACCGCTACTGCAAAATCTGTAA
Protein Sequence
MGSDSNKEYSVNWKNHMDHMRKAFDNLLTSNELTDVTLCCEGRRIGAHKMLLSACSTYFRDTFKDVPCQHPVIILYGVEYSVLSDILHFIYNGEVSVDTSKLDSFLKTAQLLKISGLTDNSTENMASENSEQDTQAASRREQTEGAFSEQVSTASEDTKKGAKRRVQESEGAPTQTKVGRQESDTLFMSDVKSEPSEFVNYEDPLEDPLLQADPSNENREFFVTSQGGVEDEIKIERTSLETTTLVRDTDIKVNKSNFSEESLRCPICSKLFSHPYSLHHHKAVHSGNTECSICHVVLSRKYNLKMHMKARHNLQFIVQEMDKKYEKHCRICVKETTNGVYLFDATISDSETYIVDFLRQITNLEISEDDGLTNILCPTCVTKVFDCFDLVQICIASDAILRSAKDTKCDSNKQNSDLIKSEDLNLPKDSEFQCRICKLTFSNKTSLNKHNKSTHKDDNPFKCDQCSQSFRKKMHLNVHQRSHTKDEDKKFFCKSCDKQFMYEYLLRQHEYKHTDEKPFPCSVCNRGCLTAESLRRHMRIHDRNYVKKKHSCEICHKEFPYPSFLAEHMKNHTGEKPHLCSTCGKGFRQSGALHYHQRIHTGDKKFSCTICNGRFMSQSVLKVHMRKHTNERPYVCHICGMAFRQSTDMKSHQRTHSGDKPVLCNICGKRMSTTGQLTIHIRSHTGEKPFSCSNCPKAFTSRAMLVKHERIHTGERPYRCNVCGKAFNQSGTLRTHKKTHECDKKRRKSEKQKEVIEDKAYQSSDAVFFKNEFVNLETEIVTDEFIGSNVQDIEVKTSDGCMKTQLTLILPAPIPLLQNL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01480260;
90% Identity
iTF_01480260;
80% Identity
iTF_01480260;