Basic Information

Gene Symbol
-
Assembly
None
Location
chr10:23190700-23194252[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.039 2.4 8.3 1.4 1 23 347 369 347 369 0.89
2 18 0.00049 0.03 14.3 0.5 1 23 375 397 375 397 0.97
3 18 0.0071 0.43 10.7 1.7 2 19 408 425 407 428 0.92
4 18 0.0066 0.4 10.8 4.2 2 23 436 457 435 457 0.96
5 18 0.0049 0.3 11.2 0.3 2 23 464 486 464 486 0.89
6 18 1.4e-07 8.4e-06 25.5 3.9 1 23 492 514 492 514 0.98
7 18 3.8e-06 0.00023 20.9 1.7 1 23 523 546 523 546 0.96
8 18 0.0077 0.47 10.5 0.0 1 23 556 579 556 579 0.91
9 18 0.0045 0.28 11.3 0.4 1 23 600 622 600 622 0.97
10 18 2.5e-05 0.0015 18.4 3.0 1 23 628 650 628 650 0.99
11 18 0.051 3.1 8.0 3.7 1 23 669 691 669 691 0.96
12 18 0.62 38 4.5 1.9 1 23 697 719 697 719 0.97
13 18 2.7e-06 0.00016 21.4 0.7 1 23 735 757 735 757 0.99
14 18 9.8e-07 5.9e-05 22.8 0.5 1 23 763 785 763 785 0.98
15 18 0.00064 0.039 14.0 0.2 1 23 791 813 791 813 0.97
16 18 0.00056 0.034 14.1 3.4 1 23 819 841 819 841 0.98
17 18 5.9e-06 0.00036 20.4 0.9 1 23 847 869 847 869 0.99
18 18 5.8e-06 0.00035 20.4 0.6 2 23 876 898 876 898 0.96

Sequence Information

Coding Sequence
ATGAGACTCGTAGTGAAAAATAGTTTAGGGCAAGTAGTTTCGTTGCAGATTAAACCTGATGAAACTTTTGTGGATTTAAAAGAAAGAGTAGAGGAAGAAGCTGGTATTTCTTTTGATTTAAGGGATATTGCGAGTAGGGGAAAAGCAATTATTGATACCCAGAAAGTTGTTGATTATTTTCTTGAACCAGCTCAACAAAATGTAGTTTGTTCCGTACCGAATTGCCCAAACACAAAAGCCAAAAATCCAGACAAAGTTTTCTTTAGCTTTCCACAAGAAGAAATTCGTTGCCATCAATGGGTTTTATATTGTCAGAGACTTAGCATGTTATCTGGAAAACATCGCCTCAACTTAACAAGTGATTCTGCGATTTGCAGCGATCATTTTCGTGAAGATCACTTTGTAAAAAATACAACAACAATCTTAAAACGTACAGCTGTGCCTTGCATTAATCCCGAATTGCCAGTTGTTGAAGCACCACCTTCTTATAACAGACGCCACAGAACTATAGTGAAAAAAGAATCTAGTAGAGATGTTACCGTGCCTATGGTTTGCCGATTATGTGCGCAATATTGTACCGACTGTATATTTATTTTTGATGAAATTGGAAAACAGTTGAGACTTTCAAATAAAATTAATTCTTGCCTCCCAATTAAAGTGACAATGACAGATCATCTTCCAAAACAAGTTTGTCGTGAATGCATTCGCCAATTAAATAAAATTTACGTTTTAGCGGAAACATGTACTAATGCAGATACCAAACTTAGAAAAATGATAAAAGAAAATGTAAGTCCCACTAGCGTAGAAGCCATGAATGAAGAGCCAAAAAATGAACAAATTTATTGTCGGAATTGCCCATTGTGTTTTGAAGGAAAAATGTGTGAACCGGAGACTCATTTGGAAGATAAACAAGATGAAAATGTTAACGAAATTGAAGAGCAGTGTAGTTCATCACCACAGCAACAAATACCTCTGAAATTTGATTTAGAAGCAATTGGCTGTGATGGTTCAGACGTGGAATCAGATGAAGAAACATTTTACAAGTGTAAACTTTGTTCCCAAGTTTTTACCAGTTTTTCTATCCTTCTGACACATTCCTTTATACATAGGGAAAGTGAATTTTATAAATGTAGCATTTGTGCAAATGACTTTGTCTCTCCAAATCACTTAAAAGAACACATGGATGAGCATAAAGCTGCAAAAGTAGAAGAAGCAGAATGTAGCTGTGACATTTGTGAAAAAACATTTAAGTCAGCTATTGCTTACAGAGCGCATTCTTGCGAAAAGAATTCTATTTTAACAAATAAATGTAAGATCTGCCATAAATCTTTTAGATCAGAAGGCAGATTGGAGTTTCATATGAAATTTCATGGTGGTGCGACACCTGGATATTGTGAAATATGCCGCAAATCATTTCCCGATGAGATTAAACTATATAAGCACACAGTGTATTTACACGCTACTGACAAAAGCTATTGTTGTGACGAATGTGGTAAAGTGTTCAAGTCACAAAGTTCATTGAAATATCATCAACGATCGCACCAAGGTGAGAATGTTATGCAGCCTTACTCCTGTGAATGGTGTAGAAAATGTTTTATCCGTAAAAGTATGCTCCGCAACCACATAGCCTCAGCTCATCAGCACATGGCTCAGGAAGCATCTTGTTTTACATGTAAAATATGCAATGAAGCTTTTCCATCGACAAATTTAGCTGTAGCCCATATGGATGCACAACATCGAGAAGAATGTTTGGCATTACCAAGTTATAGTTTTGAAATGCATACGATTACAAGGTTGTACACTTGTGAATACTGTGAGAGATATTTTGCTGAAGGAAATGCATTAAATAAACACCGCGAGTTGCATCCACAAGATTCTCCATATCAGTGTAAAATTTGTGGAAAATGTTTCTCATCGTTCGGAGAACAAAATGATCACAGATTAACACACACTGACCAAGAAATACCTGCGGAATACGTGGGCGAATTTCAGATTCCAGCAGCATATTTTTGTGAATATTGTGAGCGATGTTTTATGAATTATATAAAATTCTCAGAACATTTAACTATCCATTATGGAGTGGAACCATATCATTGCAGGTTCTGTGAACTCCGTTTTGCCACTCTTGCTAGAGCTACAGAACATAGGCTAACACATGTAGAATCTCTTGAACATACTGATGACTTTAATTTATTCAAGCCATACGAATGCCACTACTGTAGTAAGTCTTTTGCCATTGAAGACGCACTAGTAAAACATATTCGTATGCACACTGGAGAGAAACCTTTCATTTGTGATCAGTGTGGTAAAGGTTTTTCACAAAGTTCTGGCCTGTACACACATCAAAAAGTTCACTCCAATGAACGCCCTTATAATTGCCCAATTTGTCCCAGGACTTTTAAGATCAAAGGAGATCGTGATGTACACGTTCGTAAACATTCTGGTGACCGCCCGTATAAATGTGAATTTTGTGGAAAAGCTTTCATGACTCAACATGTATATTCTCAGCATCGTAAAATACATACCGGCGAAAGGCCATATAAATGTGATGTTTGTGGAATAGCATTTCGTCGATCACATGTGCTGACCGTTCATAAACGCATCCATACTGGTGAGAAACCAAATGTGTGTGATATTTGTGGCAAGAGTTACAGGCAGAAAGGAGACATGCTTAAGCATCGACGTATTAAACATGGTTTTGGTTCAGCTATGAATTCAACCCCAAGACAAATGACAAACGCAGAAGTAAGTGAAGAATTGTTGTTAGTGCGCGGATACATATAG
Protein Sequence
MRLVVKNSLGQVVSLQIKPDETFVDLKERVEEEAGISFDLRDIASRGKAIIDTQKVVDYFLEPAQQNVVCSVPNCPNTKAKNPDKVFFSFPQEEIRCHQWVLYCQRLSMLSGKHRLNLTSDSAICSDHFREDHFVKNTTTILKRTAVPCINPELPVVEAPPSYNRRHRTIVKKESSRDVTVPMVCRLCAQYCTDCIFIFDEIGKQLRLSNKINSCLPIKVTMTDHLPKQVCRECIRQLNKIYVLAETCTNADTKLRKMIKENVSPTSVEAMNEEPKNEQIYCRNCPLCFEGKMCEPETHLEDKQDENVNEIEEQCSSSPQQQIPLKFDLEAIGCDGSDVESDEETFYKCKLCSQVFTSFSILLTHSFIHRESEFYKCSICANDFVSPNHLKEHMDEHKAAKVEEAECSCDICEKTFKSAIAYRAHSCEKNSILTNKCKICHKSFRSEGRLEFHMKFHGGATPGYCEICRKSFPDEIKLYKHTVYLHATDKSYCCDECGKVFKSQSSLKYHQRSHQGENVMQPYSCEWCRKCFIRKSMLRNHIASAHQHMAQEASCFTCKICNEAFPSTNLAVAHMDAQHREECLALPSYSFEMHTITRLYTCEYCERYFAEGNALNKHRELHPQDSPYQCKICGKCFSSFGEQNDHRLTHTDQEIPAEYVGEFQIPAAYFCEYCERCFMNYIKFSEHLTIHYGVEPYHCRFCELRFATLARATEHRLTHVESLEHTDDFNLFKPYECHYCSKSFAIEDALVKHIRMHTGEKPFICDQCGKGFSQSSGLYTHQKVHSNERPYNCPICPRTFKIKGDRDVHVRKHSGDRPYKCEFCGKAFMTQHVYSQHRKIHTGERPYKCDVCGIAFRRSHVLTVHKRIHTGEKPNVCDICGKSYRQKGDMLKHRRIKHGFGSAMNSTPRQMTNAEVSEELLLVRGYI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01478860;
90% Identity
iTF_01479474;
80% Identity
iTF_01479474;