Basic Information

Gene Symbol
ZFAT
Assembly
GCA_011764245.1
Location
HIC:57967579-57975586[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.12 8.2 7.1 0.1 2 21 202 221 202 222 0.92
2 15 0.067 4.5 7.9 0.5 2 20 229 247 228 249 0.92
3 15 0.015 1 10.0 2.4 2 23 266 287 265 287 0.94
4 15 0.0068 0.46 11.1 1.7 3 23 292 313 291 313 0.94
5 15 0.011 0.72 10.5 7.1 1 23 322 344 322 345 0.95
6 15 0.00021 0.014 15.8 0.1 2 23 351 372 350 372 0.95
7 15 0.024 1.6 9.4 2.1 2 23 378 399 377 399 0.94
8 15 8.4 5.7e+02 1.3 0.6 1 23 402 425 402 425 0.85
9 15 0.00053 0.036 14.5 3.9 1 23 434 456 434 456 0.98
10 15 0.0025 0.17 12.5 1.4 1 23 462 486 462 486 0.91
11 15 0.0028 0.19 12.3 0.9 2 23 500 522 499 522 0.93
12 15 0.00096 0.065 13.7 1.6 2 23 530 551 529 551 0.95
13 15 0.0029 0.2 12.2 1.0 1 20 557 576 557 577 0.96
14 15 5.9e-07 4e-05 23.9 0.8 1 23 586 608 586 608 0.98
15 15 0.0021 0.14 12.7 2.4 5 23 617 636 615 636 0.93

Sequence Information

Coding Sequence
AGTTATGGCAATCCATTATATTTGTTTTTTTGTTTCTTTTGGATGATTCCCAGTCACTTGCATCAGTAATTAAGTACTCTTTCTCTGCTCTTTTCCTTTCTACTAACTTAATGAAATTGGTATCATAATGGAAGGTAGTTGACTTCCTACAGCCCTGCCTTATCTTGTTTACCATTCATGTTTTTTCCTTTCTAAGTTTCAGTAAGTACGTACGTAGTTAATACACGCTTAAACATGGAAGGTAAATCGGATTTGAAGCATTTCAAGAATCAAATGGATTCTATGCTGAGTGCTTTATCTCAAATGAATTCAGCTGACAAATATGTTGCATTCTCTCTTTTAAAGAAGTGTGTCTCAACAGCTCAAGATCAAACCTCTGAAACAAGTTTTACGGATTTGAATCAACAGATTGATCTTGATCCACACCATATCAAAAATGAGCAAGAATCTCTTTTGATTGACGCTTTGACTGAAGAGGAACATGGCATTGAAGGAATTTCCGTCATTGAAAACTTTGAACCCATCGAGCTTGAACCAGTTGCTCAAAACTCTGTCGAAAGTAACATTACGAATAGTTTAATGGATCTAGAGAATGCCAATAATGTTTGCCGCAACTGTTTCCAAAAATTCCCTTCACTTGATGATTTATCCTTGCATTTAGAAACTTATCCAAAAAATCCAATGTCTTGCAGAAACTGCACCAAAGAGTTCAGCAATGAATTTCTGTTCAAATTGCACGTTGACAGTAACCCATGTAAGAAGTTTCGGAAACCTATAAAAGAAAGCCTGATTAAAACGTGCACTTTTTGCCAGAGAGTGTTTTACAATGCTCAACACTATGATAGACATGTCAGTGGACATAAAAGAAACAACTGTTCCCTTTGTTCTGCCTTATTCTCAAATAGGAAACATTTAGAGACCCATATGCTGGAAATGCATGATACCAAATTAGAGAAAAATTATTTTGAATGCAAATTTTGCTTCAAAAAATTCTCCCAAAAAAGATCAATTTTAAAACACTATAAACTTCATCATTCGAAGCAGTGTTCGGTTTGCACGATCTGCGGAAAATTTTTTGATTCTTCCAACGAACTTGACGTACATCTTTTGGATCACGAAAGTAAGAAATGGACGTGCGAACCTTGCAAGCAAACTTTTATCCGGCATCAGCAGTATTTGAAACACCTTCGTGAGCATGACAAATACTTTTGTATAACATGCAATTTAGGATTTTCATCAAGAAACAAGATTATGGACCATAGTAAACTAGGTCATGCTGTCAGAGGTCTAGAGACTGTACACAAGTGTGGTGTTTGTAGTCGAGTCTGTGAATCTAAAGATAAGTTGATTCGGCATCTCAAATCTCATAAAGAGAAAGATCAATATTCTTGCAAAACCTGCAAAGTTAGCTTCAATAAAGCTGTCTATTTCAAACAACATCTCAACTCAGGTTTACACGCAGATAAATTAACAATGAGCACCAATAATTCTGTTCAATCGTGTCGACTATGTTTCAAATCATTCCCTAATAAGAATCAATTATACATTCATACACAAGAAGTCCACGGAATATCTCAGAATGTTACAAGGTGTCCGTTTTGCAATTACAAATCAAAGCAAAAAGCAAATATGAAAAGGCACATAGACCTGCATATGCAGCAAAGGAAGTATGTGTGTGATCAGTGTGGCTCAAGCTTTTATTCTTTTTCTTGTTTGAAGGAGCACATAGCGTGTGTCCACTCCACAGATAGAAATTTTAGCTGTGAAAAATGTGGAATGTCATTCAAATTAAATAGTGGTCTCAAGAGACACATGGCCACGCACAGTGAGGAGAGAACAAAGAAATGCCATTGCGGACAATCTTACAAGTTGAGCTCAAACTTAAAGCGTCATCAGTTGTTAGTTCATGGTAAAGTAGAATCCAACAGTAATTTGCAGAGACTTGTTAAAAATGATTACGGAGAGTACATTCCTGTTGAGACCAAAAAGATTTCCAAAAATAATGATAGGGAGAACAAAGAATTTCAGTTTACCGAAGATCAATCAAAGACGGTTCTGCCTCAAGACAACACGGTTCCTTTCAATGACTGTCAACTCATGCAGTCTGTGCAAGTATTTTATCAGAATTTGGACTTTCCTACGACAAATGACAGTAAACAATCTTTACTTTTCACCCCTGGCCTTGACATTGCTCATTTACAGTTGGTCGAAACCATGCTTCATGCTGCGTCTGTTAACGATCCATTGAAACAGACGCAAGATATTCTAGTAGATTCCTCAGGCCAAAATATATTTGATCGACCTATCACAGATACTGATACTTATTTAGCGACTGATGTCACTTTGAATCCTCCCATTGAAGTAGCGCAGATAACGAACCTTGATTTAACAAGTCATTCTAATCAATTAGCGCCTGATGGTTCTATTGCAAATGCTGCCGATAATCAGCAAAGTCTAATCAGCTCCTTAAGTGATTATATCATCCCTCATCAGTTTCCATTTTTGAATGTGTAGTTGAAAAACTTTTCTCGATTGTGTAATTATTTCATTTCTAAAGCCCTCCTCATTCATTTCCTCCAATTAAAGTGTAAGATTGTGACTTGTATCCAGA
Protein Sequence
SYGNPLYLFFCFFWMIPSHLHQ*LSTLSLLFSFLLT**NWYHNGR*LTSYSPALSCLPFMFFPF*VSVSTYVVNTRLNMEGKSDLKHFKNQMDSMLSALSQMNSADKYVAFSLLKKCVSTAQDQTSETSFTDLNQQIDLDPHHIKNEQESLLIDALTEEEHGIEGISVIENFEPIELEPVAQNSVESNITNSLMDLENANNVCRNCFQKFPSLDDLSLHLETYPKNPMSCRNCTKEFSNEFLFKLHVDSNPCKKFRKPIKESLIKTCTFCQRVFYNAQHYDRHVSGHKRNNCSLCSALFSNRKHLETHMLEMHDTKLEKNYFECKFCFKKFSQKRSILKHYKLHHSKQCSVCTICGKFFDSSNELDVHLLDHESKKWTCEPCKQTFIRHQQYLKHLREHDKYFCITCNLGFSSRNKIMDHSKLGHAVRGLETVHKCGVCSRVCESKDKLIRHLKSHKEKDQYSCKTCKVSFNKAVYFKQHLNSGLHADKLTMSTNNSVQSCRLCFKSFPNKNQLYIHTQEVHGISQNVTRCPFCNYKSKQKANMKRHIDLHMQQRKYVCDQCGSSFYSFSCLKEHIACVHSTDRNFSCEKCGMSFKLNSGLKRHMATHSEERTKKCHCGQSYKLSSNLKRHQLLVHGKVESNSNLQRLVKNDYGEYIPVETKKISKNNDRENKEFQFTEDQSKTVLPQDNTVPFNDCQLMQSVQVFYQNLDFPTTNDSKQSLLFTPGLDIAHLQLVETMLHAASVNDPLKQTQDILVDSSGQNIFDRPITDTDTYLATDVTLNPPIEVAQITNLDLTSHSNQLAPDGSIANAADNQQSLISSLSDYIIPHQFPFLNV*LKNFSRLCNYFISKALLIHFLQLKCKIVTCIQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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