Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0071 0.49 11.0 0.0 1 23 51 76 51 76 0.94

2 5 1.4e-05 0.00098 19.5 0.7 1 23 85 107 85 107 0.99

3 5 0.12 8 7.1 2.4 6 23 127 140 121 144 0.54

4 5 0.00027 0.018 15.5 1.0 1 21 150 170 150 175 0.93

5 5 1.1 79 4.0 0.5 1 23 181 207 181 207 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0071	0.49	11.0	0.0	1	23	51	76	51	76	0.94
2	5	1.4e-05	0.00098	19.5	0.7	1	23	85	107	85	107	0.99
3	5	0.12	8	7.1	2.4	6	23	127	140	121	144	0.54
4	5	0.00027	0.018	15.5	1.0	1	21	150	170	150	175	0.93
5	5	1.1	79	4.0	0.5	1	23	181	207	181	207	0.85

Coding Sequence: ATGGCGAGGCATGTGATCTCCTTCGTATATAAGGATGCGCCTCGGGAGGTATCTCGATGGTACAGGTGTAGCTGGGACAGGAACGCTGGAACGCTGGAACGTATAAGaCACGCTCTTCGACAACACATGCTACGCCATGCTGGCAAAAGATTCAAGTGCGGACTTCCAGGCTGCCCGACGATCCTACGCACAGCCGCCGAACTGAGGTCCCACAGACTCCTGGTGCACGAGACTTCCGCACAGGACCGGAAGTACACCTGTTCCGTATGCCCTTACGCAGCCAAGACATCGATACAGCTGAGAAGGCACACTCGAAGGCACGAGTCGCGTACCGACGAGTTTAAAGATTCCAGTTATCAATCTTGTCCTTACTCCGGCTGCCGATTCAGGACCAACTTGACGTCGCACATGAGACGTCACGCGCGTCGTCACACTGGCGTCAAGCCTTACAAGTGTCGACACTGTCCGTACGCCAGCAATAATCTGgAGAATCTCAGGAAGCACGTCATCTCGACGAATCTTCATCCTGGCCAAACGATCTACGAGTGCGACGTCTGTCAGGACGATTCGTACCAGACGAATTTCGCTAAGGAACTCAGGGCTCATCTCCTGGAAGCTCATCCGGAGAAGTTTCCAACGCCTGGTCAAGCCGGTGCTCATCTGTCTCGATACTTCGAAACCGATCCTGAGGATGAACCTGGTGCCAACTTCAACGAGTAA
Protein Sequence: MARHVISFVYKDAPREVSRWYRCSWDRNAGTLERIRHALRQHMLRHAGKRFKCGLPGCPTILRTAAELRSHRLLVHETSAQDRKYTCSVCPYAAKTSIQLRRHTRRHESRTDEFKDSSYQSCPYSGCRFRTNLTSHMRRHARRHTGVKPYKCRHCPYASNNLENLRKHVISTNLHPGQTIYECDVCQDDSYQTNFAKELRAHLLEAHPEKFPTPGQAGAHLSRYFETDPEDEPGANFNE

Sequence clustering based on sequence similarity using MMseqs2