Basic Information

Gene Symbol
ush
Assembly
GCA_963691655.1
Location
OY829329.1:80525805-80531431[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.019 1.5 10.0 0.0 1 20 226 245 226 247 0.90
2 9 0.00043 0.034 15.2 0.8 1 23 311 333 311 333 0.98
3 9 0.076 6.1 8.1 1.0 2 21 360 379 360 380 0.92
4 9 0.074 5.9 8.2 2.9 2 21 793 812 792 813 0.93
5 9 0.014 1.1 10.5 0.0 3 21 854 872 852 873 0.91
6 9 0.27 21 6.4 0.1 1 23 957 979 957 979 0.95
7 9 0.051 4.1 8.7 1.4 1 23 985 1007 985 1007 0.99
8 9 0.00035 0.028 15.5 0.5 1 23 1072 1095 1072 1095 0.96
9 9 0.4 32 5.9 0.7 2 21 1249 1268 1248 1269 0.91

Sequence Information

Coding Sequence
ATGCAGTTTGTAGATAATTCCAAAGATCTTAATCCAAACGATTCAAGCgataatcaaaatcaattaaacGACCCAAAAGTCAAACCCAAGGAGGAGGAGACTGATGTTGAAATGGCCGAAAATCGCACAGAAACTGAAGAAGAAGATACATTAACATCTCCGTATATAAAAATAGCATCACCGGATGATCGATCATCAGATGAAATGAATCGTTCATCATCAGCTTTAAATTCAAATGAACCCAACTCTCCAGATTCTATTCGAAATAGTAGTGAATTTGCAGACGGCCAAAGTGCATTTTTCTATGAAtcagaaaacgaaaaatgtgAAAGAGTAATTGAACCAAGCGAATCATTGGCTGAACCATCGGAACCTCATGTTGCTACTCCAAGTCCTAGCACAAATTTAGATGCTGATGAAATCGCAACAGCATCGCCCATGAATTTGCCAAAGCTACGTCTAAATGCATTATTAGCGTCAGATCCGGCCTTAAAACCAGATGCCAAGGACTTGAAGGCCATACACGAAGAAACACAATCTAAGAACCGCATCTCCCAATTGCCAGCTCCACCAGCATTGACCAAACAAGAAGATTTAGATACTATTTTATCAGCGCCGGTCGAACTTATTTTGAAGCCGACGCCCACTGTAGATATAGCACCTAGAATGAAAGTATTCATGTGTTTGCCATGTGGTATTGGTTTCAGTTCACCATCAACTTTGGAAGCTCACCAGGCTTATTATTGTTCGCATCGcaataaagatgttgatgatgatggtacGTCGTTAGCAACAGCAATTACCGACAAATCTTCCTCCATCAATACTTCACCAACCACCGGTGCTGGTGGTACAGGAACCACCACCGCTTCCAATACGGGTAACAGCAGTGCTGAGCCTTCAAGTAAAGCTATTAAAACTGGAAAACAATATGCCTGCACGCAGTGCTCCTACAGTGCAGATAAGAAAGTTTCACTAAATCGTCACATGCGTATGCATCAAACATCACCTGCTCTCAGTTCAAATGCCTCTAATAGCGGAGCAATTGATGAAAGTTCTAGTCAACAAATTGATCGTTATTGCAGCGATTGTGATATTAGATTCAATAATATTAAGACTTACCGGGCTCATAAGCAACATTATTGCAGTTCCAGACGTACTGAAGGGCAACTTACACCAAAGCTTGAAGTAAGCACAACAAGTTCCGTTAAAACTCCAACTGTAGGCAGTGCAATCAGCCCACAATCACGCACTAAAACTCCAACACCAGCTATGgtagctgctgctgcagctgcggcagcagcagctgcagcttCGCTACAACCATCACCACAACCTTTTCTAGCACTTCCCACTAATCCTATACTGATCATACCTTATTCATTGATTCGCGCATCAAGTTTGATACCAGGTCCATTAACGACCGCCTCCTCGGGAATCGTTAATCCAGAGACAACCTGTTTTACGCTGGATAATGGCTCCTTGAAGCCACTGGCTACGACACTCAATATGAatgcaataaatacaaatacgaCAGTGACTAGTAGTACCGCGACTAGAACATGCAATCAATTACCAATTGTGGACTCTACGCTGCAGCAACAGGTATCGATTAATGATTCGCTACTAACAGAGAAAAACGGTAGTCGTAGCGGGGAAGTTAATGAGGGAATACCAAAGCGTAAAGATGGAGTTGCACGTGAATCTGCTCCCTTGGACTTATCATTGCGACGTTCCCCCATCGCTGCCATATTGCAAAGGCAACGTTTACGTTCTGCTCCATCATTTCTTGATCCTGAGCAACAACAACGTCTCCTCGATATGGAAAAGTTGCTCGAGGCTGGCAAGGAGAATCTATCTTTGGGCGATAGTGGAAGCATAACGCCAGAGCAAATAGTGTGCGCCCCATCGCTGCCTAATAGTCCTTCAATGAGTCCTTCTCCTAAGCGACGAGCTATGAGTCCTCGAAGTTCTGGAGCTGGTAGCACATGTTCAATGTCGCCACCTGCTGGAATCTCAACAGTTTCTTTAGCTGCAGCTGCAAGTAGTATGTTGGAATTGCCACTGCGTTCGATGCTGCCTGCTGATATAGCACTAAAGCTATCCGAGTCGAATATAATGAATCCATTGTTAGCGAAACAAAATCTTGAGCTGGCATTGAAGCTATCAGCCGCTGCTGCTGCGGCTGTAAACTCTTCAACATCTGCTGCGGTTAATGTTTCTAGCAGCGCAGCTCATTCAGATTTGGTGACCGCTGCAAGCAAGTCGTCGATTTTGAGTATCCCGGTGTTGTCTGGTTCAACTGCAACAACAGCCGCTTCGAATACTGGTGGCGCAACGGGGCAACCACAAATCTATGTAAAACAGGGTGTGTCCAAGTGCAAGGAGTGCAACATCGTTTTCTGTAAATACGAAAATTATTTAGCCCACAAGCAGCACTATTGTTCGGCTCGTAATCAGGAGAACAGTGACAGTGAGACCAAGGTATCGAATACGCCACCGATGGCCGTTGGTGCATCAACAGCTGAAACTACGCCGGTCGCATATCAACAACTAATATGCGCCGCTTGTGGTATAAAATACACTTCATTGGATAACTTGAGAGCtcatcaaaattattattgccCTAAAGGAGGTGGTGCAGCTGGAACAGGTACAGCGACTACTTCTGGCCTAAGTACTACTGCGACTGATGTTGGACAGCTTCCGTTGACCAAAGAAAAGTGTAGTAAATGCAAAACCATACACGATGGACTATCGTGTCCCGTACTACCGGCTCTACAACAACAGTCTACGCAACATATATCCGGGGGCGCAATTAGTATTTCTAATGTCAGCAGCCAATCTACCGGAGCGAATCATAATGTTTATAAATGCCCTGTTTGTGATGTAATCAGCTTAACCGCAAGTGAAAGTCGGAAGCATATGGAAACACATGGCTCTGTAAAAGCATATCGTTGCAGTCTCTGCCGTTACAAAGGGAACACATTGCGTGGTATGCGTACACATATCCGTATGCACTTCGATAAGAAAACTTCTGATCTCAATGAGGAGCACTATATGTCTTGCATCCTGGAGGATGACGGTCTTGAAATACCTAGCGCTGCAGCATTAAATCAAGAGCATTTGGCCcaacaaattgccacacagcaAGCAGCAGTGGCTGCTGCAACTGTAGCTGgtttgcaacagcaacaacaattgcagcaTGTGTATAATTGTGATATCTGCAATTATTCCTCGTCTTACAAGGGGAATGTGTTGCGTCATATGAAATTAGTGCATCCCCACATTCCAATGAACTCGCCATCAATTTCGCCAGATGCTGGCGAAGTAGATGCCACTGATGTGGTATCTCTAAGTAGCAGTTTAAACGGCGACAATGGTGCGCAtagTTTTACCATAAAAACAGAACCTTTGGAACACCCTTCAGCTTTTTCGAACCAGATTACTGCTTTGGGTAAATTACAAGACAATAATAATTCGCCAGTATCACCACCAATTACAACTGTAATAAGTAACAGTATCACATCCACCCACCCCCACATCAACACCAATGCCAACGAATTACACATAAAAACTGAGCCGATGGATATCACCATTGAAACGCCGCAATTACATGCCGGAACATTGCCACCACTTATCTCGCCTGCTATAGGACCCCCACCGCCCCTGAATGCCACAACTGAGGAAAACTCAACAGACCCTGCTGCGAcggctgcagctgctgctgctaatcAAAAATATTGTCAGACATGCGACATCTCCTTCAACTACATGAAAACTTTTTTGGCTCACAAACAATACTATTGTAAGAACAAATTAAGAAGTCCCGAGACGAACGAAAGCCCCAGCCCAAATGCGGACATGTTAGCAATGACAGTGCCCTCGCCTACTACGAACGCTTTACTTCTGCAGAAGAACAAGGAGAACCTACAACAGGAAGCAGCCATTTGA
Protein Sequence
MQFVDNSKDLNPNDSSDNQNQLNDPKVKPKEEETDVEMAENRTETEEEDTLTSPYIKIASPDDRSSDEMNRSSSALNSNEPNSPDSIRNSSEFADGQSAFFYESENEKCERVIEPSESLAEPSEPHVATPSPSTNLDADEIATASPMNLPKLRLNALLASDPALKPDAKDLKAIHEETQSKNRISQLPAPPALTKQEDLDTILSAPVELILKPTPTVDIAPRMKVFMCLPCGIGFSSPSTLEAHQAYYCSHRNKDVDDDGTSLATAITDKSSSINTSPTTGAGGTGTTTASNTGNSSAEPSSKAIKTGKQYACTQCSYSADKKVSLNRHMRMHQTSPALSSNASNSGAIDESSSQQIDRYCSDCDIRFNNIKTYRAHKQHYCSSRRTEGQLTPKLEVSTTSSVKTPTVGSAISPQSRTKTPTPAMVAAAAAAAAAAAASLQPSPQPFLALPTNPILIIPYSLIRASSLIPGPLTTASSGIVNPETTCFTLDNGSLKPLATTLNMNAINTNTTVTSSTATRTCNQLPIVDSTLQQQVSINDSLLTEKNGSRSGEVNEGIPKRKDGVARESAPLDLSLRRSPIAAILQRQRLRSAPSFLDPEQQQRLLDMEKLLEAGKENLSLGDSGSITPEQIVCAPSLPNSPSMSPSPKRRAMSPRSSGAGSTCSMSPPAGISTVSLAAAASSMLELPLRSMLPADIALKLSESNIMNPLLAKQNLELALKLSAAAAAAVNSSTSAAVNVSSSAAHSDLVTAASKSSILSIPVLSGSTATTAASNTGGATGQPQIYVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQENSDSETKVSNTPPMAVGASTAETTPVAYQQLICAACGIKYTSLDNLRAHQNYYCPKGGGAAGTGTATTSGLSTTATDVGQLPLTKEKCSKCKTIHDGLSCPVLPALQQQSTQHISGGAISISNVSSQSTGANHNVYKCPVCDVISLTASESRKHMETHGSVKAYRCSLCRYKGNTLRGMRTHIRMHFDKKTSDLNEEHYMSCILEDDGLEIPSAAALNQEHLAQQIATQQAAVAAATVAGLQQQQQLQHVYNCDICNYSSSYKGNVLRHMKLVHPHIPMNSPSISPDAGEVDATDVVSLSSSLNGDNGAHSFTIKTEPLEHPSAFSNQITALGKLQDNNNSPVSPPITTVISNSITSTHPHINTNANELHIKTEPMDITIETPQLHAGTLPPLISPAIGPPPPLNATTEENSTDPAATAAAAAANQKYCQTCDISFNYMKTFLAHKQYYCKNKLRSPETNESPSPNADMLAMTVPSPTTNALLLQKNKENLQQEAAI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01133274;
90% Identity
-
80% Identity
-