Tmul005202.1
Basic Information
- Insect
- Toxonevra muliebris
- Gene Symbol
- ewg
- Assembly
- GCA_963691655.1
- Location
- OY829326.1:93539024-93546236[-]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 8e-107 7.6e-103 343.4 0.1 1 212 78 290 78 291 0.96 2 3 0.34 3.2e+03 -1.8 0.2 89 131 385 428 375 440 0.67 3 3 0.49 4.6e+03 -2.3 0.8 91 111 653 673 626 720 0.59
Sequence Information
- Coding Sequence
- ATGAATGTGACTACGGTCTCGACTGGCACCGGCACCACAACACAACACACAACCACAGCGACCCTCAATTCCAAGACCTACAAAATCGAAATGATCGATGACGGGCAAATAAGCATGTGCTCGGATGACGAGGATGATGACATCATTAGCACTGATGGCAGCATGTACGGCGATGGAGATTTGGCACAAATGGCAGTACAAGATGATGTGGCCAATCAGTTGGCAGCCGCTGGACCAGTTGGCGTGGCCGCAGCAGCTGCGATTGCTTCATCGAAAAAACGCAAGAAAGCACACTCGTTCGAAACGAACCCTTCTGTACGTAAGCGACAACAAAATAGACTGTTGCGCAAATTGCGCGGCATCATTTATGAGTTTACTGGGCGTGTCGGTAAACAAGCTGTGGTTCTGGTAGCCACACCCGGCAAACCCAATACCAGCTACAAAGTGTTTGGCGCTAAACCGTTGGAAGATGTGGTGCGAAATCTAAAGAATATTGTCATGGAAGAATTGGAAAGTGCATTGGCACAACAGGCGCCGCCTCCACCGCAAGAAGATCCTTCGCTTTTCGAATTGCCCCCATTAATTATCGATGGAATACCAACCCCAGTTGAGAAAATGACACAGGCACAGTTGCGTGCGTTTATTCCTCTAATGCTGAAGTATTCTACGGGCCGTGGTAAGCCGGGCTGGGGTCGTGAATCAACACGCCCACCATGGTGGCCTAAAGAATTACCGTGGGCTAATGTCCGCATGGATGCACGCTCTGAAGATGACAAGCAGAAGGTGAGAaTAAGCTGGACTCATGCTTTGCGTAAGATTGTCATTAATTGCTACAAATATCATGGACGTGAGGATCTTTTGCCTACGTTCGCCGATGATGAAGATAAGATTAATCAGTTGATCTCCCAGACAGGCGAAGACGAAGATGATGAAGAACCCATAACGACGACGATAGCACAACAAGTATCCAATGCCGCAACTAACACGACACATAATCAAGTAAACGTGGTGAAAATCAACAGCGCTGGCACAGTGATCACAACACATAATCcaaatttgcataataataaTCCACAACCGACCATTATACAGAGTACGAATAATCAGCATGTGACAACAACGGCTACACTGCCGGCATCGACGAAAATCGAGATCTGCACTGCGCCACAACAGTCACAGCAACACCATCAGTCACATCAGACGAGAAGTAATGAGATGACGGTCATCTCTACCACAAACGCACAAAACATTGCAAACACGCAGGTTTGCATCGATCCGATGTCTTTGAGCGATGTTGATTATACACAAACGGTGCTCTCACAAAATGCAGATGGTACTGTCTCACTGATACAAGTCGATCCTAATAATCCAATAATCACATTACCCGATGGTTCAACAGCGCAAGTCCAGGGCGTCGCTACGCTTCATCAAGGCGAAGGAGGCGCCACTATACAAACAGTACAGAGCCTTGGCGATGTGAATGGCCATGAGAATATGACTGTCGATTTGACTGAGGTCGGCCAAGATGGGCAAATTTACATAACAGCCGAGGATGGCCAAGGCTATCCTGTAACAAGTATGATAACCGTTCCAGTTACATCTGCCATGTATAATTCAATGATTGCCAACATTCAGCAAATACACACCAATAGCGATGGAACAGTGTGCATTACACCCATGCAGGTAGATTctcataataataacaataataatcacATACAGTGTTATTCAATAATGGCGGCAACAGCACCAGGCTCGGGACCCCGACTACTGGCTGCAACTAGCCAAACTATGCCACCGAATGcaaatcaaaaccaaacaaatgtagctaataataataatagtaatagtagtaataataatagtcGTAGTAGTAATAGTTGTAATAATCAAACACGTTGCCAAATATTCAATCAATCTAGTTTAAGTAATAACTCTAGTCAACCACACcaccaacatcatcaacaacaacagctacaacaacaacaacagcaaaatcaaattcaaactgcaacaacaaaagctaTGATTGCAGGTAATTTACATGCGAATCCGCTTAGTTTTAACATCAACAACACAAACTTAGCAGcaaatataaacaataacaacaatacaataaataataataacaataacaataaaattggtGGAATTACAACAAGCTTAGTGCCGCTACCCATTGTTGTAACTACTACTGGTACTCCCGCGACAGTCGTAGGCAAAGCGTCAATAACAAAACGCAGCAACAGTCAAAAACGACGtaagcaaaatttttcaaaaactgtgCCAATTAAACTCGAAAACAACACCACATCTGAGAATCTTCTGAATATACACATTGTTGACAGCCAAACGGGCCATGTGGATGTCAGCGTTAGTGGTAACAGTGGCGATGTCGTCAACTCTGTTGAtgctgatggtggtggtggtagtgatACTACTTTGCCAACCAAAGCcattaaattagaaaaaGTGGAAAATGGTGATCAACTTGAAACCATCACCGTATCGCCAGGCATGCATCAAATGATGATACAGGGCGCTGCCGGATCAGAGCCTCAGGTTCTGCAACTGGTTAGTCTCAAAGATGGCACACTGAAAACAATGGAGGTCATACATACCGGTAATGTTAAGGCGGAGGATACTATAATAATGGAGCAATAA
- Protein Sequence
- MNVTTVSTGTGTTTQHTTTATLNSKTYKIEMIDDGQISMCSDDEDDDIISTDGSMYGDGDLAQMAVQDDVANQLAAAGPVGVAAAAAIASSKKRKKAHSFETNPSVRKRQQNRLLRKLRGIIYEFTGRVGKQAVVLVATPGKPNTSYKVFGAKPLEDVVRNLKNIVMEELESALAQQAPPPPQEDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSTGRGKPGWGRESTRPPWWPKELPWANVRMDARSEDDKQKVRISWTHALRKIVINCYKYHGREDLLPTFADDEDKINQLISQTGEDEDDEEPITTTIAQQVSNAATNTTHNQVNVVKINSAGTVITTHNPNLHNNNPQPTIIQSTNNQHVTTTATLPASTKIEICTAPQQSQQHHQSHQTRSNEMTVISTTNAQNIANTQVCIDPMSLSDVDYTQTVLSQNADGTVSLIQVDPNNPIITLPDGSTAQVQGVATLHQGEGGATIQTVQSLGDVNGHENMTVDLTEVGQDGQIYITAEDGQGYPVTSMITVPVTSAMYNSMIANIQQIHTNSDGTVCITPMQVDSHNNNNNNHIQCYSIMAATAPGSGPRLLAATSQTMPPNANQNQTNVANNNNSNSSNNNSRSSNSCNNQTRCQIFNQSSLSNNSSQPHHQHHQQQQLQQQQQQNQIQTATTKAMIAGNLHANPLSFNINNTNLAANINNNNNTINNNNNNNKIGGITTSLVPLPIVVTTTGTPATVVGKASITKRSNSQKRRKQNFSKTVPIKLENNTTSENLLNIHIVDSQTGHVDVSVSGNSGDVVNSVDADGGGGSDTTLPTKAIKLEKVENGDQLETITVSPGMHQMMIQGAAGSEPQVLQLVSLKDGTLKTMEVIHTGNVKAEDTIIMEQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -