Basic Information

Insect: Tipula unca
Gene Symbol: lola
Assembly: GCA_951394425.1
Location: OX596382.1:146082819-146111182[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0023 0.34 12.9 5.3 1 21 387 407 387 408 0.97

2 7 0.00047 0.07 15.0 0.5 1 21 476 496 476 497 0.95

3 7 0.00088 0.13 14.2 1.2 1 21 708 728 708 729 0.94

4 7 0.00066 0.098 14.6 3.9 1 23 738 760 738 761 0.96

5 7 0.00066 0.098 14.6 0.4 1 21 843 863 843 864 0.96

6 7 0.047 7.1 8.7 1.6 1 23 872 895 872 895 0.97

7 7 0.071 11 8.2 1.6 1 21 1056 1077 1056 1078 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0023	0.34	12.9	5.3	1	21	387	407	387	408	0.97
2	7	0.00047	0.07	15.0	0.5	1	21	476	496	476	497	0.95
3	7	0.00088	0.13	14.2	1.2	1	21	708	728	708	729	0.94
4	7	0.00066	0.098	14.6	3.9	1	23	738	760	738	761	0.96
5	7	0.00066	0.098	14.6	0.4	1	21	843	863	843	864	0.96
6	7	0.047	7.1	8.7	1.6	1	23	872	895	872	895	0.97
7	7	0.071	11	8.2	1.6	1	21	1056	1077	1056	1078	0.94

Sequence Information

Coding Sequence: atggaggaAGATCAACAATTTTGCTTAAGATGGAATAATCATCAAAGCACGCTAATCAGCGTTTTCGATACTCTATTAGAAAATGGAACATTAGTCGATTGTACATTGGCAGCGGagggaaaatttttaaaagctcataaaGTTGTTTTATCAGCATGTAGTCCATATTTTGCAacgCTGTTATCGCAACAATATGATAAGCATCCAATATTTATATTGAAGGAtgttaaatttcaagaattacGAGCAATGATGGATTATATGTACAGGGGTGAAGTTAATATATCACAAGATCAATTAGGTGCACTATTAAAAGCGGCAGAATCATTACAAATAAAAGGTTTATCAGACAATCGAAGCAGTAAtaatacaacacaaaaaaatgatACAAAGCCACATGTACCTGTATCATCCAAgTGTGGTCTCACAATTGAACATAAAAGACCTCTAAAACATCCTGCATTAGATATTGATTCAGATATGGCAGGGTCTAGAGAAGGTTCAACTAGTCCCACATcaagaaaaaggaaaaaagTTCGAAGAAGAAGTACAGAGGGAGTTTTGTCAGATAATCATGACCACCATTCAAATTCTTCATCACAATCTCTGCCTCATGCCGCGTCCACCTCTGGATCAATAAATAACTTAGCTACCTCTGTCGTAAATGTTACCAAAAAGACTGAATTGCAGCAGCAAATagatattaaaacatcagattTAGAACACCACGGTTTAGACGAAAATGAACAAGATAATCAAGATATTGATGAAGAAGAGGAAGAAATAGTAAAACCAAATCCAGATGTAACGCAAGAAAAAAAAGATATGTTAGTAGAACCTAAAAATGAATACGATGATGGTCAGGATGAACCCGTTGAAGATTTGACAATAGAAGATGAAGAATTACTTGATGATATGGATCCAGCAGGCCCCAGTCACGGCGGTGAAAGTTCAAGTCAAGGCTATCCACAATGGCAGGTTGAACGAAGTCAAGATCAAGAATCCTTTATGTCTACTCAAGAAGCTGGATCAGGACAGCATCGCGATGCTCAAGGAGGATATGAATATAACAAACTTTATAATTCAGGACGTTTAAACAATATTCCTCCTATAGATGCATTAGTGGATGGTTATATAAATGATAAACAGGCTGAAATGTATACTTGTTATCAATGCAATCGAGTATATCGTCATCATAAAACGTTAACACGACATCTGAGGCATGAATGCGGCAAAGattttcttGATGATGAAATTCATTCAATCGTTATAACAGAAAATAAcgcaaagaaattaattaagtttaaatttataacaccaACCACAGCCACTGAAGTAATAACATCAGATGTTGATCCACTCGAAACTATTTTAACAGAATCATCATCACATTCACGTCGGAATGAAACGCAGGCTACACGTAAATTTGTGTGTCCGAAATGTGGTAAACAGTATTCTCTCTATAGAAATATGACACGTCATTTAAAtAATAATGATAGTGAAATTAGTAATAAAGTTAAATCTATTACGctaaaaaatgatgatgatgaaagaGAACATAATATCGATGAGGATGAAGATGAAGAACATGATGATAAAGTTATTGATGTAGAAGAAACAGAAGAGGAACACTCAGAAGAAGTTGATTTGCATCGTCATCAAAGTGATAGTGAtgcaACAAATGCGCAACAGTTACACCAACATAACATCATAAAAGGGATTGTAACGTTGCAGCAACAGCTGCAATCGACGccgattttaaatcgaaatttattacaaagtggataccaaaaattaaaattaaatcgtgaACATGATGTTTCATCGGTGGCTGtaacaaatttatcaaatcaTTCACAAAATAATGACGATAATAATATACATTCTTCGATAATAAGTGACTTTGATAATTACGCCGAAATTGATGATATCGAATTACCGGATGGTTCACAAATTGGTTTTAGCGTTGATGAATATTCACAATCGCATGACGGTCACAATATAAAAAGTCACTCGTCCCACCATCATCATACAGAtgatgattataaaataatgtcaGGTTccatgaaatttgaatatttaagcgATTCAGCTACAAGTGCCAATGAAGAAGGACGCCAGTACGTGTGTCGACATTGTGGCAAACGTTATCGTTGGAAATCAACTTTGCGTCGCCATGAGAATGTTGAATGTGGTGGAAAAGAGCCAATGCATCAATGTCCGCATTGTCCATATAAAGCCAAACAAAGAGGAAATCTTGGTGTTCACATACGAAAACATCATGCTGCCATGCCACCGCTAGAAAtCGCTGAAGATTTAAGCATCACACGTATTGCGGGCTTAACGTGGGATCAATGGAACGCGAGATTGGTAATGCCATTAGTAACACAGCTACGAGAAGGTGCCCATCCGTTGGTATTACCTAGGGATTTATCTGTCAGTCCATTGGATATCAAACAGCAACCAGGTAGTCCAAATAGTGGATCGGGTGGCAATGGCAGTGGTggtgcaaataataatattggtttCTCATGTGGTGATTGTGGTAGATTGTATAAACTAAAATCTTCACTGAGAAATCATCAAAAATGGGAATGTGGTAAAGAACCACAATTCCAATGTCCATATTGTGTATATcgtgcaaaacaaaaaatgcataTTGGCCGCCATATGGAACGTATGCATAAAGAACGATTTTTCAAAGTTGAAAATGATAAAGTTATTCCTTTAGATGTAGATCCTAAAATGCATATGACAGATGattctaaaatgaatttaacTATTGCTAATTTAGCTGTGGCTAATTTATCAATGGCGGCATATGATGAagatcaaaaaatgaatttgacgTCGCAATGGAATATAAGACCAGCGATGACATCAGGACAGGGCGGTATACTAAATAATGCAAGCAGTAATACAAACAAACAGAaggctaaattaattataaaacaatcaatACAAGAGCAGCAACACCAGTTTATGcgtaatattgatttaaaattttgccataAAGTTAAAAAGGAAGTTAAAATGACTaatgaaatgttatttttgCCAACGGAAAGTGAAAAACCATGGATTTGTCGTAATTGTAATCGTAATTACAAATGGAAAAATAGTCTAAAGtgtcatttaaaaaatgaatgtgGCCTACCACCAAAATACTATTGTCTACGAAATTGTGGTTACAAAACAAATATCCATTCTAATTTGAAAAgacatttaaattcaaaattttgcaaaccACCCAATGATGATCTGCTTGAGGTTCCCACATTAATTGCGACTACCCCAACTCCAAATGTTATAACCATTCCAACAACAACTAACTAA
Protein Sequence: MEEDQQFCLRWNNHQSTLISVFDTLLENGTLVDCTLAAEGKFLKAHKVVLSACSPYFATLLSQQYDKHPIFILKDVKFQELRAMMDYMYRGEVNISQDQLGALLKAAESLQIKGLSDNRSSNNTTQKNDTKPHVPVSSKCGLTIEHKRPLKHPALDIDSDMAGSREGSTSPTSRKRKKVRRRSTEGVLSDNHDHHSNSSSQSLPHAASTSGSINNLATSVVNVTKKTELQQQIDIKTSDLEHHGLDENEQDNQDIDEEEEEIVKPNPDVTQEKKDMLVEPKNEYDDGQDEPVEDLTIEDEELLDDMDPAGPSHGGESSSQGYPQWQVERSQDQESFMSTQEAGSGQHRDAQGGYEYNKLYNSGRLNNIPPIDALVDGYINDKQAEMYTCYQCNRVYRHHKTLTRHLRHECGKDFLDDEIHSIVITENNAKKLIKFKFITPTTATEVITSDVDPLETILTESSSHSRRNETQATRKFVCPKCGKQYSLYRNMTRHLNNNDSEISNKVKSITLKNDDDEREHNIDEDEDEEHDDKVIDVEETEEEHSEEVDLHRHQSDSDATNAQQLHQHNIIKGIVTLQQQLQSTPILNRNLLQSGYQKLKLNREHDVSSVAVTNLSNHSQNNDDNNIHSSIISDFDNYAEIDDIELPDGSQIGFSVDEYSQSHDGHNIKSHSSHHHHTDDDYKIMSGSMKFEYLSDSATSANEEGRQYVCRHCGKRYRWKSTLRRHENVECGGKEPMHQCPHCPYKAKQRGNLGVHIRKHHAAMPPLEIAEDLSITRIAGLTWDQWNARLVMPLVTQLREGAHPLVLPRDLSVSPLDIKQQPGSPNSGSGGNGSGGANNNIGFSCGDCGRLYKLKSSLRNHQKWECGKEPQFQCPYCVYRAKQKMHIGRHMERMHKERFFKVENDKVIPLDVDPKMHMTDDSKMNLTIANLAVANLSMAAYDEDQKMNLTSQWNIRPAMTSGQGGILNNASSNTNKQKAKLIIKQSIQEQQHQFMRNIDLKFCHKVKKEVKMTNEMLFLPTESEKPWICRNCNRNYKWKNSLKCHLKNECGLPPKYYCLRNCGYKTNIHSNLKRHLNSKFCKPPNDDLLEVPTLIATTPTPNVITIPTTTN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01458522;
90% Identity: iTF_01458522;
80% Identity: iTF_01458522;