Basic Information

Gene Symbol
IKZF1
Assembly
GCA_028551675.1
Location
JAPWLS010001313.1:35052-44330[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 0.65 35 5.1 0.4 1 23 243 266 243 266 0.95
2 21 0.45 24 5.6 6.3 1 23 273 296 273 296 0.96
3 21 2.5 1.4e+02 3.3 5.5 1 23 373 395 373 395 0.97
4 21 0.014 0.78 10.3 1.4 2 23 401 422 400 422 0.97
5 21 1 55 4.5 1.3 1 23 428 450 428 451 0.95
6 21 0.73 40 4.9 3.2 2 22 676 696 675 696 0.94
7 21 2.7 1.5e+02 3.1 1.0 1 23 799 821 799 821 0.82
8 21 0.14 7.5 7.2 0.4 2 23 954 975 953 975 0.96
9 21 0.0033 0.18 12.3 0.4 2 23 1055 1076 1055 1076 0.97
10 21 1.3 71 4.1 3.0 1 23 1084 1106 1084 1106 0.98
11 21 0.15 8.2 7.1 3.4 1 23 1133 1155 1133 1155 0.95
12 21 0.0021 0.11 12.9 7.7 1 23 1163 1185 1163 1185 0.99
13 21 5.5 3e+02 2.2 3.4 1 23 1267 1289 1267 1289 0.95
14 21 0.1 5.7 7.6 1.4 1 23 1346 1368 1346 1368 0.96
15 21 0.044 2.4 8.8 0.5 1 23 1374 1396 1374 1396 0.95
16 21 0.16 8.4 7.1 1.3 1 23 1463 1485 1463 1485 0.94
17 21 0.0041 0.23 12.0 1.6 1 23 1491 1513 1491 1513 0.95
18 21 0.0073 0.4 11.2 2.6 1 23 1600 1622 1600 1622 0.97
19 21 5.4e-05 0.0029 17.9 1.2 1 23 1628 1650 1628 1650 0.99
20 21 0.86 47 4.7 1.0 1 23 1740 1762 1740 1762 0.96
21 21 0.3 16 6.2 8.8 1 23 1773 1795 1773 1795 0.98

Sequence Information

Coding Sequence
ATGTGCGAGATATATCTACAAGCATCTATGGGTGTTCTTGCGGCAACCATCCGTATCGATCCGGCCAGGGAGGAGTGGGCTAGAGCCTCTCGGGCGGCGCAGAGTAAAACTGCCTACGTGGCGGCGCGGCGGCCCCTAGCGGGTGTCGGCGCCGAGTGCTGTCGTGTTGCTATATATAGCGTGGTGAAGCCGCGCCCGCCACGACGACGACTACAAACGCACGACGAAAGCAGGTGCGGGCGCGGGTTGCGGGGGCAGCGGGCATCCGCCTCTGCAGCGCGCCAAACCACTCACAGCGGCCAACGGACCTTAGCGACGCCATATCGATTGCGAGGGCTCCCCCTACGGCGCGCCGACCGGGATGCCTTCTCCGGCCGCTTCCTGTCGACCTCGAGTTGTCTTCAGTCCCCCGCCTTATCCAGGAGCATCACGTCCGACCCTCCGCGCCCTTCCCTCGCCCACGCGCCCTCGACAGCTCGAACATCGCCGCGCGCCTTAACCGCCTCATTCAGCCGGTATCGTTCTCGAGTATACACGTGTGTCCCGGTGCTGCCTAACGAGCACGAGCATTGTTTGTTGCAGCTGAGTATGCTACAGCAGCGGCACGCGCCGGCCGTCGCCGAGCTGCATTCGCTGGACACCCGCACTTACGGCGACACTTCTTCTGAGACCTCGTCGGACGCCGCCGAAGACTCTGAACTGCCGCAGTGCAAGATAAGAAGGAACTACAATTGTTCCCAGTGCAACTTCTATACTCAGAATCCACGTGCATATCTTGTACATATCCGAGACGTACACTTTGAAAGATTTAAGATACACGATTGTCCACATTGTGTTTACGCTTCGAGACATCACCAAAAACTTTTAAGACATATAAAAATGGTACACGAACCTAGCAACATCGTCAAACAAGAGGAGGACGCGACCTCGACGGCGAGCGACACCATGGAAAATATTGAGGACATGCTTGAAGAAGTCGAAGACAGCTCGGACATGCAGGATGATGACATGTCATATCAAGACGAAATATTTGAAAACTCAATGGACGTTGAAGACACGAGTAATATGGAGGAACCCCTAGCTGAGTCTGGAACGCGAAATGCTAGAAGTAATTTATTCTCATGCAACAAATGCAACTACGTGACGCATATCAAATCGCGGTACACAAAACACGTGAAATATCATTCAATGCCGATGACCAAATGCACTTTGTGCGAATTTCGTACACCATACAAGTGGAATCTCGATCGTCACATGAAAAATCACGGCGGCGGGAGATTATATAGTTGTTCTATGTGCAACTTTACAGCAGATATCAAGCAGAGCCTGACCGTGCATGAGATGAATCATCATTCACCGGCGGTGGGCCAATCGCTCGCAAGCCGCCGCCGTAATCGGGTGGGTGCCAGCGACGTTCTCACGGACGACGCATCGGGCTCTCTCGAAACCAAAGAGGAGGAAGGGAGCGGTGACTCGCGTTCCTCGCACTCGGTGCCGGATTACGATTCGCACATTCCAGACATAACGGATATGTTAAACAATGATTCAAACGATATGTCACCAAAAGGAGATGACGAACATCTGAAAGATTCAAATCAAGGAGATGATAAAGCAATGGGCAGAAAAAAAGCAAGACCAATACCCCCGTTGATACCGCTGAATGCTTCTGCGCCAAATCAAAATAAAACATCTTTTGAACCACCACATAAAAAAATGAGGGAATCGATTAACACACCTACATCAGACATTGATAATAACGAATATACAACTGCAGATATAGCTTCAGCCACTTCCAATACAATCTATACAAAGCATGAAAATGCGCCTAAGAAGAAAAACGAGTCCTTCTTTGATAAGCTAAAAGAAAGATTACTTACTGAAACAGGGAAAGAGGGTTCCCTAACATGTAAAGATTGCGGATTTGAAAGTAAATGCCTTTCAGAGCACTCGGTCCATGAAAAGAATTGTACAGCCCAATCTAACCGCCTTCTAGCAAACGCTGGACCCTCTACATTGGGTTCAACTAGATGTCAAAATTGTAGACACAGGTGTAAGTCGAGCGCGGATTTATACATTCACTTGCAAACTTGTGCCATGAAAAATAAAATGGAGACTGATCAAATAACAGAAACAAAAATTCAGAACAACAAGGATGGAGATGGAATACAGATGGATCGGGAAATCGGTCCACATCCGATGGAGAATGTAGTGTTTGTATGGAATAACATTGGCCAAGATTGTAATAAATTTGATAGCCCTCTTGATATTAATATTCAAGAAGATGCAACTTTACCTAAAACACAAAATAGATCTTACGACCCTAACAACGTAGATGCTCTTCATGATAATGAAGGAATGAACTTATCTCCGACTCAAGCGGTCGGTAAAAAAGTTTATAAGTGTCCGCACTGCCCGTTTTGGGCGTCAACTGCGTCCCGATTCCACGTTCATATTGTCGGGCACCTGAATAAAAAACCATTTGAATGTTCATTGTGTCAATATAAATCGAATTGGCGTTGGGATATTACTAAACATATTAAACTCAAGTCTGCTAGAGACTCGATCCACAATGAAGCCAAAGTATTAATGACAGATGAAACTGGAAGGCGTAATTACAGCAAATACAACAAATTTTTGGCTATGCTAAAGTTGAACGAGAATGGTACAAATGAATTTCAATATATAGATACTGGTACAGCGAACGTTGATGCTACGATAGAACTAGATGAGACTATAAATGACACATATAACGATAGTGGTGTACAGATGCACATGCAGCCATTAAACTTGCAAACATATTCAAAAGCAGGCACACCTGAAAACAGCATTGAAGATAAGAAGCCAAAGAAAACACTATGGAAATGCAAGAAATGCAACTACAAGGACTCATCGAAAGAAGCTTTAATAGAGCACGTCCGGGAACATTCCAGAGCGATGGAAGGCAACCAGGAGAGCCTGAAACAAATCATCAAGAGAGCAGAATCTTCTAGGGAGCAGAGTGACCTGGCATATCGCTGTGGACACTGTAATCAATTGTCTAATTGGAAACATGTAATCCAGAGGCATTGTCGACTGAAGCATGACGGAGTTATAAAAGTTATTGCAACTGAAAAACCTAAACAGGATCAGACTCATATATCTTTATCAGAATTAAATGTTAATTATTGTCCGAAATGTCCGTTCGCAACAAGCGACAAGAAGGAGATGATAAATCATATGCAGAATCATATGCCATCATCGCAATCTATATTCAAATGTTACTTTTGCTATTATTTTGCGAAAACTGAACATGAATTAGTACAACATTTATCAATACACGGAGTATCTGATCCAGAAGAGTTCATAACCAAGGGTGGTAAAGAATTGACATCGGACCAAACGTGCGGAACTAAAAGACACAAGTGTACGGAATGTCCTTATGAGACAAACAGCAGATCACAATTCATGTATCACGAACAGTTTCACCGTCTTCCCGCCGACACTCCATACAAGTGCCACGAGTGTAATTATAGTGTATCTAAAAGGCACTTACTTCACCAGCATATGAAGGTGCACGGTATTGCTGTACCGAAGAAAGATAATGACCCGGATGAATACAACTCACTCAACTACATCAAAGACGAGATGCCTTCAGAACAATTTAACGAAGATATATCATACGTTTGGGTCGCCACTAAAAATGAATTCCATAAAATGTACAAGTGTCGCTATTGCTCGTATGTAAATTCACAAAGGTGTAAGATCCCGACACATGAAAAAATTCACGTGACCTTTTTAGAAAACAGTGAGTTGGTTATTTACAAATGTCTAGAATGTAAATATACCTGTCAAAGTGCACTGCGATTGTCTGAACATTCCAAGAGCCATAGTGAGATATATGGCCGAATATATTTTAATGTGGAGAGCGACGTACCGGATGAAGAGCAAATAGAAAAATTACGAGAAGTAATAGAAGAGGAGAAGAAATTGGAAACAGAATCATCTGAGAGTAAAGACTATGATTCAACAAATGGTGGGGACGAAGATAAAACTATATTCTTTTGCCAAAAATGCCCTGCTAGATTTTTTTCTGACAATGAATTAAAAATCCACGAAAGATTTCATGATTTGGTATTTTCTTTTAAATGCAAATTATGCGAATTCTCTGTTCCACAAGAAACTCAACTTACAGCTCATTCGTTTGTACATACAGACGAATACCAAGATAAAACAAAAATGTTAAAGATGATGCATGATACACATCCTGACTACAAAGAACCCATATTAGAGCTAGTACACTGTCCCAAAACATCCGAAATTACCTGGGTCGTCCCACAAAAGAACAAAAAGCGAGCATTCGACCATAATCCAAAGAAAATTAGTGATAACAAAACTGGACCTAAGCAATATTATTGCAAATCATGTCCTGCGAAATTTTTTAAGAATTCCGCTTTGTCATACCACAGAGGTCTACATGGCGGTGAAGGTGACCATAGGTGCAAGAAGTGTGATTATACTGTAAAAAATGTAGGAAACTTGGCTAAGCACGAGTCGTTACACGAAGACAAGAGCAACTGCGATTATGAATCTGGCGAAGATATGGACTATAAAAACATCCCGCTCTCTGGTACAGATTTGTTTCAAAGAAAAACTGAAGCTCAAAAAAGAGTATTGATCGATAAAGATAAATTAGTGAAACCAAATGATCACTTTCCGCCCGTGCTCCAAGCTGATCCTCAGTTTGGTTATTTAATACATGGAAATCCTGAATTTATATACCCGACGTACATGAAAAATGGAAGACAAAAAGAGAAACGTTATAAATGCCACAAATGTCCTTCAGCATTTGAGAAAAGAGAGCAGTATAAAATTCATTTATCTTTACATGGCTCTAAACAACGGTACAAATGTGAAATATGTGATTATTCTGTCAAATACTATGCAAATTATGTTCAGCATATGCGAAAACATCAAATGAATGATGAAGCGCAGGCTGAAAGAAAGAAAGACACCGATTTAACCGAGACACCAATTCAATCCACTAATAAAGATGATAGTAATGACAATATAAGATTGGCAATAAAGACGATGCCTAGAAGTGTAGTGAAGAGCGACTTTCAACAATTCTCTTTTAGTGATCAGCAAACATTGAGACTTTTACAAAGGAGGCGCTCCATAAACTCGGCTTTAAACGACTCAACAACGCCCGAGACCGCAATAACAAAAGAAAAAAAGCTACACATGTGTGTACTATGCCCCTACAGCAACCAACGTCAAGATGCACTGGCGAATCACTATAAGAGACACGACAATAAAGATATTATTAATACGGGTAGTCATAAATGCTGCCATTGTGATTTAACTGTAGTACAATCACATTTCCTTAGAGATCATATGAAATTACATTTCAACTTTCTCAGACCACAATGTTATACTGCCAATGAAGATGTACAATTCACCATAAACAAAATTGACGAAAATGATTCTAACGTAGTAATAAGTTTAGACACAGTGGGTGAAGCATATAAATCTACTGCTGATAGGATATACGTGCAGGTTGCTACTGGTGAAATAACAGTCGATCAATAA
Protein Sequence
MCEIYLQASMGVLAATIRIDPAREEWARASRAAQSKTAYVAARRPLAGVGAECCRVAIYSVVKPRPPRRRLQTHDESRCGRGLRGQRASASAARQTTHSGQRTLATPYRLRGLPLRRADRDAFSGRFLSTSSCLQSPALSRSITSDPPRPSLAHAPSTARTSPRALTASFSRYRSRVYTCVPVLPNEHEHCLLQLSMLQQRHAPAVAELHSLDTRTYGDTSSETSSDAAEDSELPQCKIRRNYNCSQCNFYTQNPRAYLVHIRDVHFERFKIHDCPHCVYASRHHQKLLRHIKMVHEPSNIVKQEEDATSTASDTMENIEDMLEEVEDSSDMQDDDMSYQDEIFENSMDVEDTSNMEEPLAESGTRNARSNLFSCNKCNYVTHIKSRYTKHVKYHSMPMTKCTLCEFRTPYKWNLDRHMKNHGGGRLYSCSMCNFTADIKQSLTVHEMNHHSPAVGQSLASRRRNRVGASDVLTDDASGSLETKEEEGSGDSRSSHSVPDYDSHIPDITDMLNNDSNDMSPKGDDEHLKDSNQGDDKAMGRKKARPIPPLIPLNASAPNQNKTSFEPPHKKMRESINTPTSDIDNNEYTTADIASATSNTIYTKHENAPKKKNESFFDKLKERLLTETGKEGSLTCKDCGFESKCLSEHSVHEKNCTAQSNRLLANAGPSTLGSTRCQNCRHRCKSSADLYIHLQTCAMKNKMETDQITETKIQNNKDGDGIQMDREIGPHPMENVVFVWNNIGQDCNKFDSPLDINIQEDATLPKTQNRSYDPNNVDALHDNEGMNLSPTQAVGKKVYKCPHCPFWASTASRFHVHIVGHLNKKPFECSLCQYKSNWRWDITKHIKLKSARDSIHNEAKVLMTDETGRRNYSKYNKFLAMLKLNENGTNEFQYIDTGTANVDATIELDETINDTYNDSGVQMHMQPLNLQTYSKAGTPENSIEDKKPKKTLWKCKKCNYKDSSKEALIEHVREHSRAMEGNQESLKQIIKRAESSREQSDLAYRCGHCNQLSNWKHVIQRHCRLKHDGVIKVIATEKPKQDQTHISLSELNVNYCPKCPFATSDKKEMINHMQNHMPSSQSIFKCYFCYYFAKTEHELVQHLSIHGVSDPEEFITKGGKELTSDQTCGTKRHKCTECPYETNSRSQFMYHEQFHRLPADTPYKCHECNYSVSKRHLLHQHMKVHGIAVPKKDNDPDEYNSLNYIKDEMPSEQFNEDISYVWVATKNEFHKMYKCRYCSYVNSQRCKIPTHEKIHVTFLENSELVIYKCLECKYTCQSALRLSEHSKSHSEIYGRIYFNVESDVPDEEQIEKLREVIEEEKKLETESSESKDYDSTNGGDEDKTIFFCQKCPARFFSDNELKIHERFHDLVFSFKCKLCEFSVPQETQLTAHSFVHTDEYQDKTKMLKMMHDTHPDYKEPILELVHCPKTSEITWVVPQKNKKRAFDHNPKKISDNKTGPKQYYCKSCPAKFFKNSALSYHRGLHGGEGDHRCKKCDYTVKNVGNLAKHESLHEDKSNCDYESGEDMDYKNIPLSGTDLFQRKTEAQKRVLIDKDKLVKPNDHFPPVLQADPQFGYLIHGNPEFIYPTYMKNGRQKEKRYKCHKCPSAFEKREQYKIHLSLHGSKQRYKCEICDYSVKYYANYVQHMRKHQMNDEAQAERKKDTDLTETPIQSTNKDDSNDNIRLAIKTMPRSVVKSDFQQFSFSDQQTLRLLQRRRSINSALNDSTTPETAITKEKKLHMCVLCPYSNQRQDALANHYKRHDNKDIINTGSHKCCHCDLTVVQSHFLRDHMKLHFNFLRPQCYTANEDVQFTINKIDENDSNVVISLDTVGEAYKSTADRIYVQVATGEITVDQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-