Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2 1.1e+02 3.6 3.5 1 21 156 177 156 180 0.67

2 6 4.7 2.6e+02 2.4 2.5 3 23 190 208 188 208 0.69

3 6 0.002 0.11 13.0 3.4 2 23 215 236 214 236 0.95

4 6 0.001 0.056 13.9 0.2 1 23 242 265 242 265 0.98

5 6 1.3e-05 0.00071 19.9 2.9 1 23 271 293 271 293 0.95

6 6 1.4e-05 0.00076 19.8 2.6 1 23 299 322 299 322 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2	1.1e+02	3.6	3.5	1	21	156	177	156	180	0.67
2	6	4.7	2.6e+02	2.4	2.5	3	23	190	208	188	208	0.69
3	6	0.002	0.11	13.0	3.4	2	23	215	236	214	236	0.95
4	6	0.001	0.056	13.9	0.2	1	23	242	265	242	265	0.98
5	6	1.3e-05	0.00071	19.9	2.9	1	23	271	293	271	293	0.95
6	6	1.4e-05	0.00076	19.8	2.6	1	23	299	322	299	322	0.96

Coding Sequence: ATGGCTACGGTTTTCAATAATGTTAGTTATAATTCCCATTGTCGAGTGTGCATGTTGGAATGTATTGATGAATCGGATATATTTCACGACATATTTGATAGAATAAATGATAAATTTTGTTCATACAGTGAAAGTATATCGTTTTGCACTGGTTTAAAAATATCAAAAGATGACGGATTGCCATCAATAATATGTGAGCCATGCATTAACGACTTGAGAATCACGCATAGGTTCATAAAAACGTCTCTAATAACAAACAAAAGACTGCATACACCTCAACAGAAGTTGTTGATACCAATATACACACCGCTGGAAGAAGAAGTCTGTGATGTGGTCTACAAGGAAGTGGAACAGTTACAAGTGTCTCCTAGAAGAAATGATAGAATAGGAAAGCAGAATGGAAGGGTTAAAAATACATCGAAGAAGAAGACGCAAAAGAAAAGTGTAATCCCAAAAAGTAAACATCACAGATGCACCCTATGTAACATTAGCTTTGGTAGTAGCCATGTTGAATACAAAAAGCATAAACTGAAATTTCATCCGTATCCTGTGAAGGCATCTAGTATATGCGAGGTCTGCGGTAAATCTATAGTTCGTGGGTATAACAGGCATCTGTTGACGCACAAGGAGTCCATGGTTCTGTGCTGCGAGCATTGCCAATACAAGACTTCTAATAAATACTTGCTTGCGACGCACATGGGCGTGCATTTTAAGACACGAAGCTTCCAATGTGAATATTGTTCCGCTACACCGACGAGTTTAGCAAATTTACGTGCGCACATTAAGAGGAATCATACGAACGATCGTAATTTTAAGTGTGCGCAGTGCGGTAGAGCCTTCTGCTATAAGAGTGAGTTACAACAGCATCTGGACTTTCATATGGGGATTAAACGGTACCACTGCGACAAGTGTGATAAAATGTATTCGGATTTGCAAGATCTGAAGAAACACCTCTCGAAGATACACGAAATAGTAACGCTGAAAAGTAAATCCGGTCCGAAAACAACACACGACATTATTGGAACTAACAAACACGGCGAGGTTCTCCTGGTTGCCAAGAAAATTATTTGA
Protein Sequence: MATVFNNVSYNSHCRVCMLECIDESDIFHDIFDRINDKFCSYSESISFCTGLKISKDDGLPSIICEPCINDLRITHRFIKTSLITNKRLHTPQQKLLIPIYTPLEEEVCDVVYKEVEQLQVSPRRNDRIGKQNGRVKNTSKKKTQKKSVIPKSKHHRCTLCNISFGSSHVEYKKHKLKFHPYPVKASSICEVCGKSIVRGYNRHLLTHKESMVLCCEHCQYKTSNKYLLATHMGVHFKTRSFQCEYCSATPTSLANLRAHIKRNHTNDRNFKCAQCGRAFCYKSELQQHLDFHMGIKRYHCDKCDKMYSDLQDLKKHLSKIHEIVTLKSKSGPKTTHDIIGTNKHGEVLLVAKKII

Sequence clustering based on sequence similarity using MMseqs2