Basic Information

Gene Symbol
-
Assembly
GCA_905220615.1
Location
HG992331.1:6311948-6315630[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00051 0.028 15.1 0.6 3 23 111 132 109 132 0.96
2 17 2.1e-05 0.0012 19.4 1.9 1 23 141 164 141 164 0.97
3 17 1.5 86 4.2 0.4 2 23 177 199 176 199 0.92
4 17 0.0033 0.18 12.6 2.3 1 23 208 231 208 231 0.97
5 17 0.00013 0.0072 17.0 0.6 2 23 246 268 245 268 0.97
6 17 0.00033 0.019 15.7 1.0 2 23 290 312 290 312 0.97
7 17 0.0017 0.097 13.4 0.9 1 23 321 344 321 344 0.97
8 17 0.0028 0.16 12.7 1.5 3 21 353 371 352 372 0.94
9 17 0.0027 0.15 12.8 2.1 1 23 376 399 376 399 0.97
10 17 0.0023 0.13 13.0 3.9 1 23 405 428 405 428 0.93
11 17 0.0027 0.15 12.8 5.1 1 23 433 456 433 456 0.96
12 17 0.2 11 7.0 3.6 1 23 466 489 466 489 0.93
13 17 0.017 0.97 10.3 0.1 2 23 533 553 532 553 0.95
14 17 0.0052 0.29 11.9 1.1 1 23 556 578 556 578 0.99
15 17 0.053 3 8.8 2.5 1 23 613 635 613 635 0.94
16 17 0.00033 0.018 15.7 3.4 1 23 642 664 642 664 0.99
17 17 0.034 1.9 9.4 4.6 1 23 670 693 670 693 0.98

Sequence Information

Coding Sequence
ATGACTGAAGCAGGCAAAATGGACCCAACATCTTTACTACCTGAAGAACCCATGTCATATGAAATTAAGAAGAAAAAACGCAAAAAGAAATCCAAGAGGGATCCCCTTGATGACAGCTTTGCACCAAGTAATATTCCAATCACCTTCGAACCTGATCGTATTAAAGTGGAGAATATTGAAGTGATTCCAGAAGTTGAGGAGCTTTTAGATGACAATTTCGCGTCAGCAGATGAAATCATGAACGATATGGACGACTCTGATTCATTACCAGATTTACAACAGGACCTGGAGGATGAAATACGCGAGCCAGTTCCATTTGAAGGGCTCTTCTGTGACATTTGCAATTCAGTGTTTACCAAAAAAAGTTTTTTAATAGCTCATAGAAATAGAATACATAAAATTTATGACGATGAACTTGAATATAAATGCAAACAGTGTTACAGAGCGTTTAAAAATAAAGAAAGTTTACGGGTGCATGCCAATCGACTACATAAACCTAATAAGGTCAAAATAGATCAAAGTATTAAAGTCTGTGATATTTGTTCCGCTAACCTCAAAGGAGCTGATCGGTTAAATAGACATAAGTTCAGTCAGCATGGTGTTCCACTTGAAATATTCAAACACAAATGCCCATATTGTACAATGACATACAACATCTATGGCAGTTTAGTGATGCATATGAAGAGGAAGCATGTTGAAAGCGATTCTGAGACAATGCAAGACAATGCTTTGTCTCAATGTCCATTTTGTGAAAAAATGTTTAATATAAAAGCATCATTAATAAACCATATAAAAAAGACTCACAAGCACCAAGAAGAAACTATAAAGGATGAATTAGATGAATGTATTGATATTAATGGAGAAGCGAAATGCCCCTCATGCTCCATCAGTTTTCGCACGACAAGATGGCTTAAACTGCATATGCAAAGAGTTCATGGTTTGTATAAGGAATTATTTCAGTTCACATGCAAAATATGTAACATGAGTTATGATAACATCATTAGTCTTAATACCCATGCAAAGAGAAAGCATGGCGTTGGTAAAGGAAGAAGATTTTGCAAAATATGTCAGAGACACTTTGATAATAAAGACCTATACGAACGGCATGTAAAGCAAGGCACAAAGTTTGTTTGTAAACAATGCAAAGCTGTTTTTGAAACTCACTTAATGTTAACGCGACATGTTAATTCCAAACATGGGACTGGATTAAAGCATTTCTGCCACCAGTGTGGTAAGGATTTTATTAGTTTAAAGAGTCTCACGGAACATGCGAAATTAAAACATGAAATGCGTGAATATAGTTGTTTGAAATGTAGTAAAAAATACAAATCTAAGCATGCTTTGAGAGCTCATAATAAAAGAACTCACGCAGAAGAAGATATGAGTGCAACAAAGCATAAATGTATTATATGTAATAAAGTTTTTAACGATGAATTACGTCTATGCAAGCACACTGAAAAGATACATAAGTGTAAAGACACAACAAACTATAGGTGTGCAAAATGTGAACAAGAACACGACTCCATAGAAGAATTAATGAAGCATTTTGTAGCTGCACATGACAAAGAAGTAAATGACGAAGAGGGCATGAATATAAGCTGCGACAAATGTGGCATTTCAGTGAACAGTAAAAACTTGGAAGCACATTCCGCTACTCATACAAGTTACAAATGTAATTATTGTGAATATGAAACTGAAGCCCGCATTGAATTTACAAAACACATGCTTCGTCATAAAGATGCAACTACAATAAAATGTGGCATAGACAACTGCAACTATTCCACCTACAATACATTCATTTTGGAAAAGCACAAACTCAGACATCAATCAAACAAATTTAAATGTAAAACTTGTGCTTTCACGACCACAAATAAGTATTTGTTGAAGTATCATGAAGATGAACACGTGAACGGCAAAAAAGTCTACAAATGCAAGAGCTGTGATTACACAACAGTCACGCAATCAAACATGCAACAGCACAAACAAAAACACGAAACAAAGCGCAAATACAAATGTAGTTTTTGCGATTTTGCTACTCATTATAATACTTCTTTAAGAGATCATATTAAGAAGAAACATAGAGATTTATAA
Protein Sequence
MTEAGKMDPTSLLPEEPMSYEIKKKKRKKKSKRDPLDDSFAPSNIPITFEPDRIKVENIEVIPEVEELLDDNFASADEIMNDMDDSDSLPDLQQDLEDEIREPVPFEGLFCDICNSVFTKKSFLIAHRNRIHKIYDDELEYKCKQCYRAFKNKESLRVHANRLHKPNKVKIDQSIKVCDICSANLKGADRLNRHKFSQHGVPLEIFKHKCPYCTMTYNIYGSLVMHMKRKHVESDSETMQDNALSQCPFCEKMFNIKASLINHIKKTHKHQEETIKDELDECIDINGEAKCPSCSISFRTTRWLKLHMQRVHGLYKELFQFTCKICNMSYDNIISLNTHAKRKHGVGKGRRFCKICQRHFDNKDLYERHVKQGTKFVCKQCKAVFETHLMLTRHVNSKHGTGLKHFCHQCGKDFISLKSLTEHAKLKHEMREYSCLKCSKKYKSKHALRAHNKRTHAEEDMSATKHKCIICNKVFNDELRLCKHTEKIHKCKDTTNYRCAKCEQEHDSIEELMKHFVAAHDKEVNDEEGMNISCDKCGISVNSKNLEAHSATHTSYKCNYCEYETEARIEFTKHMLRHKDATTIKCGIDNCNYSTYNTFILEKHKLRHQSNKFKCKTCAFTTTNKYLLKYHEDEHVNGKKVYKCKSCDYTTVTQSNMQQHKQKHETKRKYKCSFCDFATHYNTSLRDHIKKKHRDL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-