Basic Information

Gene Symbol
Zfx
Assembly
GCA_948150575.1
Location
OX411273.1:1956937-1973755[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.1 5.8 7.6 1.4 1 23 238 261 238 261 0.96
2 11 0.067 3.7 8.2 0.3 1 23 268 290 268 290 0.98
3 11 0.046 2.6 8.7 0.3 1 23 294 317 294 317 0.95
4 11 1.5 82 4.0 1.1 1 8 324 331 324 346 0.77
5 11 8.5e-06 0.00047 20.4 1.5 2 23 351 373 351 373 0.97
6 11 0.00022 0.012 16.0 0.4 1 23 379 401 379 401 0.98
7 11 0.049 2.7 8.6 1.2 3 21 414 432 413 437 0.91
8 11 5.3e-05 0.0029 17.9 2.2 1 23 445 468 445 468 0.94
9 11 0.00076 0.042 14.3 3.3 1 23 473 496 473 496 0.97
10 11 5.8e-06 0.00032 21.0 2.3 3 23 505 525 504 525 0.98
11 11 2e-06 0.00011 22.4 1.3 1 23 531 554 531 554 0.95

Sequence Information

Coding Sequence
ATGAAGAAAAAAGAAAGTTTAACTCAAAATTCAATATGTTCTGCCTGTTTATGTGCGGGCAGAGAGTTACAGAATATTTCTAACATCGTTTCAAAGCAGTTCTATTTAAGTGTAATACAAGAATTACCATTACCAAAAAGTTTGGATTCTGAGCCTCAAGTATGTTGGGAGTGTAATTGCGTATTAAAAAGGATAATATTGTTTAAAGAGCAAATAAAAGACTGCTATCGAATTTTACATGGCTACACTAATGAGGATATTTCCGAGATATCCCGTCTACCAAGACTCTCTGTGAGATGCATTTCACCTATCAATATAATACCAGAGCTGCAAAAAGAGGATGATGTATTGGATATAAGTTTGGTTAAGAATGAAGATGTCAATGGGCTGGAGTTATGTTTAATTAAAAATGAACACAAGAGTACTGAAAATTTGAAACAAGAAAATGAACAATCGGACTGCGACGGACAATACATGTCGGATGGCTCAGATAATTTATATATAGATGAAACATACGTAGATCATGTTGTTGAGAAATGTAAGAAGAAGGACAAAGCAAGGGAACAAATTGAGGAAATTACGTTTAAAGAACAGTTAAAAAGGCAAAAAAGTACTGCGACACAGAAATTAAGAACTATAGAACTGACGTACGAAGAGATGTTGTTAGAAAGAGCACGGGACGCGTTGAAATGCAATTATGTGAATGCACAATATAAATGTGATCTTTGCCTCATCGGTTTCAATTATGTCAAATCATACAAAAGTCATGTTAAAAATAAACATTCTGAGAAGTTAGGCGATTACAATTGTCCCGTTTGTAAAACTGTAATGGGTAGTGTCGAATCTTTCACGGCTCACTACAAGAGACATTTGAGAAGATATGAATGTTTGGCGTGCGGCAAGCGGACGATGGATCGTAAATTTCTGATGCAGCATTACGCGTCGGCGCACGAAGGGCACGTTAAAGAATATAAATGCGATATATGCGACAAGTTATCTTATACGATCGACGCGCACCGTTACCACAAAGGTACCCACAAGAAGAGAGCTGAATGCAAAGAGTGCGACAAGACTTTCAGCCATCGAGCGGGACTCCTCAATCATAGATTGACCGTTCACAAGTTAAATAAAGGATTCCCATGTACAGTTTGTGACAAAATATTTAGATGGAAAGCTAGTGTTAGAAAACATATGGAGAAGCATAATAAAAAGACCGACACACCGTCTAATCAGCCAGTATGCGAGCCCTGCGGTGTCACCTTCTCAAGTATATGCTCATACCAGCGTCACATGAAGAATAGTTTGAAACACGTCACAGAAAATGAATTAAGATATATATGCGATCACTGTAACAGAAAGTTCGCAAATAAAACCAAATTAAGGGATCACATCGAGGAGAAACATCTGCACAGGACGTACCAATGTTCTATATGTCACAAGCCTTCAAAAAATCGTGTATGTCTGGACCAGCATATCAGGAACGTTCATAAAGGCAGACCGAAAAATAAAATATGTCACCATTGCGGCAAAGGATTCCCTACAAAAGTACAATTGGATTCGCATATAAGATCTCACACTGGCGAGAAACCGTTCATATGTGAATATTGTCCGACAACATTCTCGCAGCAATCTAACTTGTACAAGCATAACAGGCAGGTACACATGAATATAAAGGCGAAACGTTACCCAATTGATCGTAAACGCAAGGAAAAGTCTGACCAACCCATAAACACAATACCGTTCTATAATAGAGACATGCCTACTCTATTGCACGCTCAAGACAAACATGACTTTGCTGTTTGA
Protein Sequence
MKKKESLTQNSICSACLCAGRELQNISNIVSKQFYLSVIQELPLPKSLDSEPQVCWECNCVLKRIILFKEQIKDCYRILHGYTNEDISEISRLPRLSVRCISPINIIPELQKEDDVLDISLVKNEDVNGLELCLIKNEHKSTENLKQENEQSDCDGQYMSDGSDNLYIDETYVDHVVEKCKKKDKAREQIEEITFKEQLKRQKSTATQKLRTIELTYEEMLLERARDALKCNYVNAQYKCDLCLIGFNYVKSYKSHVKNKHSEKLGDYNCPVCKTVMGSVESFTAHYKRHLRRYECLACGKRTMDRKFLMQHYASAHEGHVKEYKCDICDKLSYTIDAHRYHKGTHKKRAECKECDKTFSHRAGLLNHRLTVHKLNKGFPCTVCDKIFRWKASVRKHMEKHNKKTDTPSNQPVCEPCGVTFSSICSYQRHMKNSLKHVTENELRYICDHCNRKFANKTKLRDHIEEKHLHRTYQCSICHKPSKNRVCLDQHIRNVHKGRPKNKICHHCGKGFPTKVQLDSHIRSHTGEKPFICEYCPTTFSQQSNLYKHNRQVHMNIKAKRYPIDRKRKEKSDQPINTIPFYNRDMPTLLHAQDKHDFAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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