Basic Information

Transcription Factor Domain

TF Family: HPD
Domain: HPD domain
PFAM: PF05044
TF Group: Helix-turn-helix
Description: Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here [1]. This homeo-prospero domain binds to DNA.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0016 66 5.4 0.1 24 48 55 79 23 84 0.92

2 8 0.0024 96 4.9 0.1 23 48 88 113 79 118 0.84

3 8 0.0014 59 5.6 0.1 24 48 123 147 113 154 0.87

4 8 0.0038 1.5e+02 4.2 0.1 23 48 156 181 147 187 0.84

5 8 0.008 3.2e+02 3.2 0.2 21 48 205 232 194 240 0.81

6 8 0.0057 2.3e+02 3.7 0.0 23 48 241 266 234 272 0.89

7 8 0.008 3.3e+02 3.2 0.0 23 48 275 300 266 305 0.86

8 8 0.0016 67 5.4 0.1 24 48 310 334 303 341 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0016	66	5.4	0.1	24	48	55	79	23	84	0.92
2	8	0.0024	96	4.9	0.1	23	48	88	113	79	118	0.84
3	8	0.0014	59	5.6	0.1	24	48	123	147	113	154	0.87
4	8	0.0038	1.5e+02	4.2	0.1	23	48	156	181	147	187	0.84
5	8	0.008	3.2e+02	3.2	0.2	21	48	205	232	194	240	0.81
6	8	0.0057	2.3e+02	3.7	0.0	23	48	241	266	234	272	0.89
7	8	0.008	3.3e+02	3.2	0.0	23	48	275	300	266	305	0.86
8	8	0.0016	67	5.4	0.1	24	48	310	334	303	341	0.89

Coding Sequence: ATGCAAATCAATACGATGGTGTCGAGCGAGGCTGACCAGACTCTTGGCAATGGCTACAGTCAAGTGTTCATAGAGAGGGCCTTAACTGACAGCTTAATGAGCTACTACAGTCAAGTCTTCATAGAGAGGGCCTTAACTGACAGCTTGAGGGTCTTAACTGACAGCTTGGTGAGCTACTTCAGTCATGtgttcatagaaagggccttaaCTGACAGCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTGGTGAGATACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAAATGACAGCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTAGTGAGCTACTACAGTCATGTGTTCATAGAGATGGCCTTAACTGACAGCTTGGTGAGCTACTACAGGCATGTGTTCATAAAGAGGGCCTTAACCGACAGCTTGGTGAGCTACTACAGTCAAGTGTTCATAGAGAGGGCCTTAACTGACAGCTTGGTGAGCTACTACAGTCAAACGTTCATAGAGAGGGCCTTAATTGACATCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTAGTGAGCTACTTAAGTCATGTATTCATAGAGAGGGCCTTAACTGACAGCTTAGTGAGCTACTTAAGTCATGTATTCATAGAGAGGGCCTTAACTGACAGATTAGTGAGCTACTTCAGTCATGTGGTCATAGAGAGGGCCTTAACTGACAGCTTAGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGACAGCTTGGTGAGCTACTTCAGTCAAGCGTTCATAGAGAGGGCCTTAACTGACATTCTTGGTGAGCTACTTCAGTCATGTGTTCATAGAGAGGGCCTTAACTGA
Protein Sequence: MQINTMVSSEADQTLGNGYSQVFIERALTDSLMSYYSQVFIERALTDSLRVLTDSLVSYFSHVFIERALTDSLVSYFSHVFIERALTDSLVRYFSHVFIERALTDSLVSYFSHVFIERALNDSLVSYFSHVFIERALTDSLVSYFSHVFIERALTDSLVSYFSHVFIERALTDSLVSYYSHVFIEMALTDSLVSYYRHVFIKRALTDSLVSYYSQVFIERALTDSLVSYYSQTFIERALIDILVSYFSHVFIERALTDSLVSYLSHVFIERALTDSLVSYLSHVFIERALTDRLVSYFSHVVIERALTDSLVSYFSHVFIERALTDSLVSYFSQAFIERALTDILGELLQSCVHREGLN*

Sequence clustering based on sequence similarity using MMseqs2