Basic Information

Gene Symbol
ZFHX3
Assembly
GCA_902155825.1
Location
CABFWO010006208.1:1-18533[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.22 42 6.8 0.5 1 23 42 65 42 65 0.95
2 15 0.074 14 8.3 0.0 1 23 85 108 85 108 0.92
3 15 0.0087 1.6 11.3 1.7 2 22 221 241 221 244 0.90
4 15 0.23 43 6.8 1.1 3 23 258 281 256 281 0.88
5 15 0.017 3.1 10.4 1.7 1 23 303 325 303 325 0.97
6 15 0.0042 0.79 12.3 0.9 2 23 332 354 331 354 0.96
7 15 0.00098 0.18 14.3 3.9 1 23 467 491 467 491 0.92
8 15 0.012 2.2 10.9 0.6 1 22 511 532 511 535 0.89
9 15 0.0016 0.29 13.6 0.2 1 23 595 619 595 619 0.93
10 15 5.3 1e+03 2.5 0.0 6 21 752 767 750 768 0.87
11 15 1.2 2.2e+02 4.6 1.6 2 19 910 927 909 932 0.91
12 15 0.00025 0.046 16.1 2.5 1 23 1608 1630 1608 1630 0.99
13 15 0.0011 0.2 14.1 0.3 1 23 1769 1791 1769 1791 0.98
14 15 0.023 4.3 9.9 0.2 2 23 1941 1963 1940 1963 0.96
15 15 6.8 1.3e+03 2.2 3.1 2 23 2261 2284 2261 2284 0.89

Sequence Information

Coding Sequence
NACCCCCGCAAAGACCACCAACAACAGCGCCAGCAGCTGTCCAACAGGGAGCAGCAACACCATATCGAGAAGTCTGAGCAGGAACCGGAAGACACCATCATGACCAACTCTTCCAACCACCAACACATGTGCCCCTACTGCAACTACACGAGTAGCTCAGAGATGCGCATCCAGGCACACGTTCTCACCGCGCACGGTCATTCAGAGCCGTCGCCTCCTCCTCCCGCGAGGGCCTCTTCGCCCATCAAAGACTTCCTATGCCCTCTTTGTCAGGACGGATTCCGGGACCGCGCGCAGCTCGAGGTCCACGTCATGCAGATCCACAGCGTCAACAGCGAAGGTCTCCAAAGGTTGCTGCTACTGGTGGACCAGTCCCACTGGCTGAACGCCGTCAGTAGATCGTCGGCCCCTTCCACCCCACAATCTCAACCGACACCCCACCACCCCCAACACCATACACCTCCCGGATCCAACTCTCACCCCCATCACAACCAGATGATCTCACCCTCCTCCAGCTCGGCCGGATCCTCCAAAGAACTCGACTCCAGTGGGGGTAAACAGAACAACTCTGACGTAAACTCCATAGAGGACCGTGAAGATCACTCCCATCCGGACCTCATGTCCCCGTCTCCCGATGATCAGAGTGACGCGGATGAGAACCGTTGCCAGACGTGCTTCAAAGTCTTCAGAAATATCGATGAACTATGCGCTCACCAGAACGAGACTGGTCACCTTGAGATTAAGCAAACTCCGTCTGGGCCAGGCTATCTCTGTTGGAAGAAAGGGTGCAACCAGTATTTTCCGACGGCTCATAGTTTACAAATGCACTTCAGGGAGATACATTCCTCTAGAAGCTCAGGACTGACGCAGCAAGGCATGGCGGTCTCCGAGAAACATGTATACAAGTACCGGTGCAATCAATGCAGTCTTGCGTTCAAAACGATGGAAAAACTTCAGCTCCATTCCCAATATCACCTTATAAGAGATGCCACCAAGTGTGTCCTCTGTGGTAGAAGCTTCAGGTCCGTCATTGCTTTGCATAAACACGTGGAAACCTCTCACGCAGAACTGACAGATGAAGAACTAGCGGCTTACAAACAGAGCTTGATGAATAACCCTTTGTTACTAGCTGGTTTCAGTGGACAAGTCCTTGACTCGTCGACGAACGAATTGCTCAAGAAAGAGAGCCTCAAGATGGACTCTGATGACTTGATAGATACGGATGAGAGTCCAACCAAAGACCACTCGCACAATCAGGATGACGGGATGGGAAACTCTCACAGCGGGGATGGGGAGAACAGCGACGACTCGGTGGTGTACAAAGAGCAGCAGTTCCTAGAGGATTACCTCAACAGCCAGGCCATCGCCGAGGATAGTTACAACGACCCTAACCGCAAGTACAAGTGTCACAGGTGCAAAGTTGCTTTCACAAGACAGAGCTACCTAACGAGTCACAACAAGACGCTCCTGCATCGTAAAGGAGAAAAGTTGAGCTACCCCATGGAGAAATATCTCGACCCCAACAGACCTTACAAGTGCGACGTATGCAAAGAATCTTTCACACAGAAAAACATTCTTCTGGTTCATTACAACTCTGTAAGTCATCTTCACAAACTCAAGAGAGCGATGCAggaacaacaacaacagcataataataataataatggtgctACATCTGTTTCCCCCGTCTCCGCAGCGGCAGCTCTCGCTGCAAGCTTGGGAGTTACGCCTCCACCAACCCCAAAATCCAGCAACATCTTGGATGATGATGACAAGAAACCTTACAAGTGTAACATCTGCAAAGTGGCTTACAGCCAAGGTTCCACTTTGGACATACACATGAGGTCAGTTCTTCATCAGACTCGAGCATCCAAGCTCCAGGACCTCGCCATCAGCGGTCAGATTGATCTGAGCAAGCCTCTCATAGAGCAACCCGAGCCTCAGAAGATCCAAGACCAGCACAAGAAGATGCTTCAGGACATTCTAGGGACGTCCCCTAAACAGACGATGACGTCGCCAAGCTCCGGCGTGAACACGAGCAGCAGCAGCGTGACTTCGCAAGTGCCGTCTCTAGCCCAGGGGTCTCCTCCCGTCACGGGCAGTCATATAGTTCCTCAATCGTCTAGCGCTGCCGCTGTATCGGCTTCGACACCGACCATGACTTCAGTTCCTAGTAGCGTTATGCCTAACAACGCCACGACACCTACCTTGAGTACAACCAGCCACATCAACAACGCTCAAGCGCCGCCTAGGTGCAGTGCCCTTTTCGCCAACCAAGAGCAGCTGACCACGCATCAGCAGCTCTACTGTCTCTTCGGCAGTCCCATGAATATCTTCCCTCCTCTGCCCACGCCAACTCAGGCGTCTACCCAGACTCACCCTTCCCATTGTTCTCCTCAACCCTCTGGCCACAAAACACCCCCTCCAGTGTCCACGACCCCTCATCTTCAAGACGACCCTTTTCCTAGAGTGTCTGCGGGGAACAAGAAGCCCTCGCAAGTGTACAAACATCTTCTCGAGAGCTTCGGTTTTGATTTGGTCATGCAGTTCAACGAGAACCACCAGAGACGGCAAAGGAAAGAGAGGGAGGAAGAGAACGAGGCCCCTCCTCCGCCGATGCCAAGCTCCCTGACGCCGCAACAGCCCGAAACCCAACCGGAAGGCGTTGTCGTGAAAATCGAGGTGGAAGACGTCCCCGAGCAAGATCTTCCAGAAGTGGCAAAGTCTGTTTGTCAGCATTGCCGAAAGGAGTTCTCCAGCGTGTGGGTTCTCAAAGCTCACTGCGAGGAGGTCCACAGAGACTTGGTACCCCCAGAGTTCCTGGAGAAATACGCGCAGCAGATCAAGTCCGAATACGAGAAGAAAGGGGCGAACGCAGCAGGGGCGCCCAGCGCTCCAGGACCTGTGATCCAGATCTCGACAAGCAGCAACACCGACGCTGTCCCCGAGAAGGAACCCGAAGACAACAAAGAAGCGCTTCACGCCAAAATGGGTTTGAGCCAACCCCAACAGCATAACCACCACCGGCAGTCCACTCCGCCCGTGAGGACGCCACCCGCGCCTAGTACGCCCACGGCGTCGTCCACACCGGCGTCCAGCACTGATTCAATACCGGCGACGCTCTCAACGCCCATGGCCGTCTCGATGATGGGCTCCGCCAACAACGTCGCGTCCGGCAACCCCCAGAGTCTGTCCATGTCGCTGGCGCAGCAGATGAACGAGATGCAGGCGGCACTGAACGTCATGGCGGCGTCTCAGCTCCAACAGCAGCTGCAGCAGTTCAACCCCATGATGATGGGAATGGCGGGGCTTGGGATGGGGCTGCCCCTGGGGCTCAATATGAACGCTCTGGCGGCGATGAACCTCCAGCCGCCCCTGGTGCCCATGATGATGCCACCCCCGCCCTTCGACACGATGAGTCTAGCGCAGGCGCAGAGCCCGTTGTTCTCACCGCAGGGTGGGGGCATGGACCATACATCCCTGCTTGCTAAGCAACAGCAACACCTCCTTCAACAGCAACAGCAGGCGGTATCGGCGGCCCAGCAGAAGAGGGCAAGGACACGCATCACCGACGATCAGCTCAAGATCTTGCGTGCGCACTTTGATATCAACAACTCACCCTCCGAGGATCAGATCCACGAGATGGCGGGGCAGTCGGGGCTCCCCCCTAAAGTTATCAAACACTGGTTCAGGAACACTCTGTTCAAAGAACGACAGAGGAACAAAGACTCGCCCTACAACTTCAACAACCCACCGTCGACCACCCTCAACCTGGAGGAGTACGAGAAGACGGGAGAGACCAAGGTGATGCCACTCAACAGCAGCAGCAGTAGCAATGAAGACCAGAACCCTAAAGAGTTCTCCCAAAGAGCCCCGGCTGCTACCTCTACCCCTTCCTCGTCCAACAAGAGGAAACAATCTCAACCCCAATCTTTGCCGCAGCCCCAGCCCTTTCCTCCAGAAATGATCAAGTTGGAGCCGAGAGAAAGTATCCCTTCTCACAACCTAGACAATCAAGAGCACAAGTTTAACAATCTGTTCATGGATTCGGTCCATAGAAAAGATGTGGAAATACCTGAAGATAAACCACAGAACTTACGCCAACTTCCGAGCCCTTTATCAGGGATGGGGTGTTTGCCACCAAGCACCCCTACAATTAACGAATGTAATATTATGTCGACCAACACCCCTTTGAATGTGCGGACCTCCTCCCCTAACAATTTGACCTTGACCTCTATTATCGCCTCTCAATTGGGTTCAGACTCTATCACCACTTCTCACCCCAATATGGGGATGAACTTGACCGCTGTGAATTCATCTCAAAACACAAGTGCTAGTAATATGTTGCCACCCAAACTCACCCCACCCAACTTTACTTCCCCCAATCACATGCCTACTTCTCCCAACATTCTCCCTCTCACCCCTTCCTCGAGGTCGGTCAGCCCCGGCAGATCCTACAACAACAACTCCTCGGATGGTTTCGGGCATGGGGTTCTTGGGGGTGGCTGTGGAACAGGTGGGAATAGTAATGGGAGCAACTCCTCAGGAGGGTCGTCGGGGAAGCGTGCCAATAGGACTCGCTTCACGGACTACCAGATCAAAGTACTTCAGGAGTTCTTCGAGAACAATGCGTATCCTAAAGATGACGACTTGGAATACCTCTCAAAGTTGCTGAGCTTAAGTCCTAGAGTTATTGTAGTCTGGTTTCAGAACGCACGCCAGAAAGCTAGAAAGGTTTACGAAAACCAACCCCCTGTTGAAGCGCCACCCGGCGTCGACGAGACCGGTGCGAATAGGTTTCAAAGAACCCCTGGGCTGAACTATCAGTGCAAGAAATGTTTGCTAGTTTTCCAGAGGTACTATGAACTCATCAGGCATCAGAAAACGCACTGTTTCAAAGAGGAAGACGCAAAGAGATCCGCACAAGCTCAGGCGGCAGCAGCGCAAATCGCTGCCGTTCTTTCGTCGGAAGATTCAAACTCTAGTACAATTGCTGAACAGAGTCAACAGCAACCGCAACAACAACAACCGCAGCATCAACATCAACAATCGccacatcatcatcaacaatcGCCGCACCATCATCAACAACATCAGCAGCAGCATCAGCAACAACCCCCACCCTCTTCGACGTCTCAATCACATCAACAACAGCAGACTAACATGGTTTCTGTATCAACCGCGTCGGGTAACCCAGCCACCCCTCCTGGCTCAGTAACACCCACACCTGCCTCATCATTATTCCCGTCCTCCCCTATCGCGAGTACTCCTACCCCCACAGATAACTCCAGTAAAGAAGGTACCTTTCAATGTGACAAGTGCAACCTTGTGTTTCCTCGTTTCGATCTCTGGAGAGAGCATCAACTCGTTCATATCATGAACCCAAACTTGTTCCCTACGTATCCTCCTGACAGCCCTTTTGGAATATTACAGCAGCATGCCCAGATACAACAGCAGCAGCACTTGGCAGGCTTGGGGGTGGCGGATCTATCCATGAATTCCTCCACCACCCCTCCCCATCAACATCCCCTAGCGTCGATGCTATCTAGCAGCAAGCGAAAGTATGAGGACTACGAGGATGTTATGGATAGAGACGGCGATCAACCCAAAGACAAGAGACTTCGAACCACGATTCTCCCTGAACAGTTGGATTACCTTTATCAAAAATATCAGCTAGAAAGCAACCCGTCTCgaaaaatgttggaaaatatAGCTAGAGAGGTAGGTCTGAAGAAAAGGGTGGTCCAAGTCTGGTTTCAAAACACTCGAGCCAGGGAACGAAAGGGTCAGTTCAGGGCGCACGCCCAAGTGATTAACAAGAGGTGCCCCTTCTGCCCCGCTCTGTTCAAGGTAAAGTCTGCCCTTGAATCCCACCTAGTCACGAAACACGCGGATCAATGTACTAGGGGAGAGATAAACATCGACGCTCTGCCCGACGAAGAACTCAGCATGGAATCCGCGCcgtccttcagctcccagatgGGCGACAGCGTTAAAGTTCCTACGAGTTTCGGATCCAACAATCCGACGCCGAACATGATGCCCCCCCTGTTCCCACCTTTCCACTCAGCCGATATGGAAAGTTCACTGAAAAAGTATTATGAAGAATCGATGAAGCGTTATCTCAACGAGCTTCAAGCGCATCACGTGGCTCAGAACGGAGGTATAGGAAAGGAAGGAATACACATTCCTACAGATCTCAGCATGAAAATAAAGCAGGAACCTTCTTTATCGGAAGTAGTAGGAGACAGAGGGGGCAGCGTTTGTGGAGCAGATGGTCCGCTTGATCTCAGCAAACCTGTGGACTTGAGCCGACCCATGAAAGTGTCCATGGATCATGAGATGAGGTCAATGATGGCCGAGCAAGGCCCTTTAACTGACCTGAGTGAGAGGAGCATCTGCTACGACGATGACAGCGCCTCAGAAACGACTGAAATTATGGATGGCGATGAGAGTAACCCCACTTCGCCCGCCTCTAGTACACAAAGCGGTCACCAAAGGCATTCCACTTCTGGAGGGGGAAGCAGTGGGGGTGGAAAGAGATTTAGGACGCAGATGAGCAGCTTGCAAGTCAAGGCTATGAAATCTCTCTTTTCTGACTATAAAACTCCTACTATGGCGGAATGTGAAATGCTTGGAAGAGAAATAGGCCTTCCGAAAAGGGTGGTCCAAGTTTGGTTCCAAAATGCCAGGGCTAAGGAGAAAAAGAACAAGCTCGCACTTCAGAAGGTTCTGGGAGGTCCTGAACAACCTATCCAAGAAGGATCTCGGTCGCCCGAGGAGTGTAAGCTCTGTTTGTTCAAGTACTCGCACAAGTACTCAATCCAGGACCACATCTTCACCAAGAAGCATATCGACAACGTAAAGGCGCACATCGAGAGCGGAAAAGCCGCGGCGGATAATTCTGGCAACACCAGCGACGGAGGTTCCGTGGCGGGAGAGTTCACCGTCCCACCGGTCCCAGGGCTGTCCGGGGTTGGCGGTGACGTCACCGTCCCGCCCCCTACGCAGTCTCCTCAGTTCAACAACAACCAACAACAGCTGGCGCAGCTCCAGATGCTTCAGATGGCCGGCCTGTCTCTACCCAACTCGCTGTCGGCGCAGGCGATGGCTGCCGCGGCTTCCGGGGTAAAGGTGGAGAAGGACGCAGGGTCCAAGTCGCCGGCTCCGGGAGGTGTTCCGGGTCCGGAGGATATGGCGCTGCTACATCAGCTGTATGGACTGGGTCTGGCCGGATTCCCCGGAGCGGGCAACCTGTTCCTTCATCCCGCCATGTTCTCTGCTGCCGATGGTAAAATAATGTCTGAAGAAGATAATGGGAGCCCGATTGCTTTCGTCACCCTCCGGTATCGAAACCATTCGACTGTCTCCCCTGCCCGTGTTCAAAGACAATCAGCTTGGCCCGACAATGAGGCAATACAAGGAAACACTTTGTCCTCATTGTTGCCGGTGTTACGCCCCCTCACTCCTACCCTCTTACAGAATGCGAGGAGAACCTCACCAGGAGGACCCACTGAAGGCATCGGATGGCCCAAGAAGAAGGAAGAAGCCCGCGTCGGTACCTTTTGA
Protein Sequence
XPRKDHQQQRQQLSNREQQHHIEKSEQEPEDTIMTNSSNHQHMCPYCNYTSSSEMRIQAHVLTAHGHSEPSPPPPARASSPIKDFLCPLCQDGFRDRAQLEVHVMQIHSVNSEGLQRLLLLVDQSHWLNAVSRSSAPSTPQSQPTPHHPQHHTPPGSNSHPHHNQMISPSSSSAGSSKELDSSGGKQNNSDVNSIEDREDHSHPDLMSPSPDDQSDADENRCQTCFKVFRNIDELCAHQNETGHLEIKQTPSGPGYLCWKKGCNQYFPTAHSLQMHFREIHSSRSSGLTQQGMAVSEKHVYKYRCNQCSLAFKTMEKLQLHSQYHLIRDATKCVLCGRSFRSVIALHKHVETSHAELTDEELAAYKQSLMNNPLLLAGFSGQVLDSSTNELLKKESLKMDSDDLIDTDESPTKDHSHNQDDGMGNSHSGDGENSDDSVVYKEQQFLEDYLNSQAIAEDSYNDPNRKYKCHRCKVAFTRQSYLTSHNKTLLHRKGEKLSYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQQQHNNNNNGATSVSPVSAAAALAASLGVTPPPTPKSSNILDDDDKKPYKCNICKVAYSQGSTLDIHMRSVLHQTRASKLQDLAISGQIDLSKPLIEQPEPQKIQDQHKKMLQDILGTSPKQTMTSPSSGVNTSSSSVTSQVPSLAQGSPPVTGSHIVPQSSSAAAVSASTPTMTSVPSSVMPNNATTPTLSTTSHINNAQAPPRCSALFANQEQLTTHQQLYCLFGSPMNIFPPLPTPTQASTQTHPSHCSPQPSGHKTPPPVSTTPHLQDDPFPRVSAGNKKPSQVYKHLLESFGFDLVMQFNENHQRRQRKEREEENEAPPPPMPSSLTPQQPETQPEGVVVKIEVEDVPEQDLPEVAKSVCQHCRKEFSSVWVLKAHCEEVHRDLVPPEFLEKYAQQIKSEYEKKGANAAGAPSAPGPVIQISTSSNTDAVPEKEPEDNKEALHAKMGLSQPQQHNHHRQSTPPVRTPPAPSTPTASSTPASSTDSIPATLSTPMAVSMMGSANNVASGNPQSLSMSLAQQMNEMQAALNVMAASQLQQQLQQFNPMMMGMAGLGMGLPLGLNMNALAAMNLQPPLVPMMMPPPPFDTMSLAQAQSPLFSPQGGGMDHTSLLAKQQQHLLQQQQQAVSAAQQKRARTRITDDQLKILRAHFDINNSPSEDQIHEMAGQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGETKVMPLNSSSSSNEDQNPKEFSQRAPAATSTPSSSNKRKQSQPQSLPQPQPFPPEMIKLEPRESIPSHNLDNQEHKFNNLFMDSVHRKDVEIPEDKPQNLRQLPSPLSGMGCLPPSTPTINECNIMSTNTPLNVRTSSPNNLTLTSIIASQLGSDSITTSHPNMGMNLTAVNSSQNTSASNMLPPKLTPPNFTSPNHMPTSPNILPLTPSSRSVSPGRSYNNNSSDGFGHGVLGGGCGTGGNSNGSNSSGGSSGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLSLSPRVIVVWFQNARQKARKVYENQPPVEAPPGVDETGANRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAVLSSEDSNSSTIAEQSQQQPQQQQPQHQHQQSPHHHQQSPHHHQQHQQQHQQQPPPSSTSQSHQQQQTNMVSVSTASGNPATPPGSVTPTPASSLFPSSPIASTPTPTDNSSKEGTFQCDKCNLVFPRFDLWREHQLVHIMNPNLFPTYPPDSPFGILQQHAQIQQQQHLAGLGVADLSMNSSTTPPHQHPLASMLSSSKRKYEDYEDVMDRDGDQPKDKRLRTTILPEQLDYLYQKYQLESNPSRKMLENIAREVGLKKRVVQVWFQNTRARERKGQFRAHAQVINKRCPFCPALFKVKSALESHLVTKHADQCTRGEINIDALPDEELSMESAPSFSSQMGDSVKVPTSFGSNNPTPNMMPPLFPPFHSADMESSLKKYYEESMKRYLNELQAHHVAQNGGIGKEGIHIPTDLSMKIKQEPSLSEVVGDRGGSVCGADGPLDLSKPVDLSRPMKVSMDHEMRSMMAEQGPLTDLSERSICYDDDSASETTEIMDGDESNPTSPASSTQSGHQRHSTSGGGSSGGGKRFRTQMSSLQVKAMKSLFSDYKTPTMAECEMLGREIGLPKRVVQVWFQNARAKEKKNKLALQKVLGGPEQPIQEGSRSPEECKLCLFKYSHKYSIQDHIFTKKHIDNVKAHIESGKAAADNSGNTSDGGSVAGEFTVPPVPGLSGVGGDVTVPPPTQSPQFNNNQQQLAQLQMLQMAGLSLPNSLSAQAMAAAASGVKVEKDAGSKSPAPGGVPGPEDMALLHQLYGLGLAGFPGAGNLFLHPAMFSAADGKIMSEEDNGSPIAFVTLRYRNHSTVSPARVQRQSAWPDNEAIQGNTLSSLLPVLRPLTPTLLQNARRTSPGGPTEGIGWPKKKEEARVGTF*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01444540;
90% Identity
iTF_01445137;
80% Identity
iTF_01447317;