Basic Information

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.13 3.2e+03 -0.2 0.2 143 171 59 85 18 105 0.51

2 3 0.11 2.8e+03 -0.0 0.4 122 183 136 195 95 203 0.62

3 3 2.7e-36 6.6e-32 113.0 0.0 84 196 203 313 197 314 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.13	3.2e+03	-0.2	0.2	143	171	59	85	18	105	0.51
2	3	0.11	2.8e+03	-0.0	0.4	122	183	136	195	95	203	0.62
3	3	2.7e-36	6.6e-32	113.0	0.0	84	196	203	313	197	314	0.96

Coding Sequence: ATGACCCTAGCTGAGTGGTTAGCtctcaaatatatatctacatGTCTGGGGGTAACTCACACCGCTGGTCACGTGGTTGAAAGAGAGGATATTGTAACCCACACCGCTAGTCACGTGGTTGAAAGAGAGGATATTGTAACCCACACCGCTAGTCACGTGGTTGAAAGAGAGGATATTGTAACCCACACCGCTGGTCACGTGGTTGAAAGAGAGGATATTGTAACCCATACCGTTGGTCACGTGGTTGAAAGAGAGGATATTGTAACCCATACCGCTGGTCACGTGGTTGAAAGAGAGGATATTGTAGCCCACACCGCTAGTCACGTGGTTGAAAGAGAGGATATTGTAGCCCACACCGCTGGTCACGTGGTGGAAAGAGAGGATATTGTAACCCACACCGCTAGTCACGTGGTTGAAAGAGAGGATATTGTAACCCACACCGCTAGTCACTTGGTTGAAAGAGAGGATATTGTAACCCACACCGCTAGTCACGTGGTTGAAAGAGAGGATATTTTAACCCACACCGCTAGTCACGTGGTTGAAAGAGAGGATATTGTAACCCACACCGCTGGTCACGTGGTTGAAAGAGAGGATATTGTAACCCACACCGGTGAGGCGATCCATCTAGCCAGAGACTTCGGGTACGTGTGTGAGACGGAGTTCCCAGCGCGCCAAGTGGCGGAGTATCTAAGCAGACAACACACGGACCCCTCAGAGTCGTACCGGCGCAAAGAGCTCATCCACGCCACCAAACAAATCACCAAAGAGTTGATGGATCTTCTGAATCAAGACAGGTCTCCCTTATGCAACACTCGGCCTCAGCATATCCTGGACCCAAGCATACAAAGACATCTCACTCACTTCTCTCTCATCTCTCACGGGTTCGGTAGTCCGGCCATCGTGGCAGCTCTCACTGCGATACAGAATTTTCTGACAGAGTCTTTAAAACACTTGGACAAGATGTACCCGTCTGGTAACAATGGTGGAGCTCACATATCGGTGTCTTCGTCCCAACAACAAGGAGGCATGGACACAAAACCCAAAGATCTGGGAGACCTCAAGAAGTGA
Protein Sequence: MTLAEWLALKYISTCLGVTHTAGHVVEREDIVTHTASHVVEREDIVTHTASHVVEREDIVTHTAGHVVEREDIVTHTVGHVVEREDIVTHTAGHVVEREDIVAHTASHVVEREDIVAHTAGHVVEREDIVTHTASHVVEREDIVTHTASHLVEREDIVTHTASHVVEREDILTHTASHVVEREDIVTHTAGHVVEREDIVTHTGEAIHLARDFGYVCETEFPARQVAEYLSRQHTDPSESYRRKELIHATKQITKELMDLLNQDRSPLCNTRPQHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNFLTESLKHLDKMYPSGNNGGAHISVSSSQQQGGMDTKPKDLGDLKK*

Sequence clustering based on sequence similarity using MMseqs2