Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.3 5.7e+04 -4.1 0.4 57 65 31 39 28 40 0.78

2 2 1.3e-41 1.7e-37 130.2 0.0 3 80 64 141 62 141 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.3	5.7e+04	-4.1	0.4	57	65	31	39	28	40	0.78
2	2	1.3e-41	1.7e-37	130.2	0.0	3	80	64	141	62	141	0.98

Coding Sequence: ATGCATCTGCCGGGCCCGTTGGCAACCGTATCTTCAGCGTGCGCAGGTGAAGGTGCGTTCACCTGCAAGAAACGTCGGACGATGGCCGACGGCGGCAACGACAACAACGACTCCACCAACGGTAACGGTGGCGGTAACAGCGGCGCGGGCGCCAACGAGGACCTCTGGTGGACGGAGAGGGTGCTGTGCGAGGTGCAGGCCGAGCACTCGGGGGAGCTCGTCAGGACGGGGAGTCCCTACTTCCTCTGCTCGGCGCTACCGACGCACTGGAGGTCCAACAAGACGCTGCCCATCGCGTTCAAGGTGGTGGCGCTAGGGGACGTCGTGGACGGTACTCTGGTGACTGTGAGGGCGGGCAACGACGAGAACTACTGCGCGGAACTGAGGAACTGCACCGCCGTCATGAAGAACCAGGTGGCCAAG
Protein Sequence: MHLPGPLATVSSACAGEGAFTCKKRRTMADGGNDNNDSTNGNGGGNSGAGANEDLWWTERVLCEVQAEHSGELVRTGSPYFLCSALPTHWRSNKTLPIAFKVVALGDVVDGTLVTVRAGNDENYCAELRNCTAVMKNQVAK

Sequence clustering based on sequence similarity using MMseqs2